Abstract：
:It has been repeatedly noted that the change of conformation of the molecules that serve as the ion-selective channels for sodium and potassium conductance in the nerve membrane will be accompanied by a change in the dipole moment of the molecule. This time-dependent change of dipole moment will produce transient currents in the membrane. The canonical form for these currents is determined with conventional statistical mechanics formalism. It is pointed out that the voltage dependence of the conductance channel conductance determines the free energy of the system to within a factor that is an unknown function of the voltage. Since the dipole currents do not depend on this unknown function, they are completely determined 0y the observed properties of the conductance system. The predicted properties of these dipole currents, their time constants and strengths, are calculated. By using the observed properties of gating currents, the density of the sodium channels is computed. The predicted properties of the dipole currents are found to compare satisfactorily with the observed properties of gating currents.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Strandberg MWdoi
10.1016/S0006-3495(77)85587-2subject
Has Abstractpub_date
1977-09-01 00:00:00pages
275-84issue
3eissn
0006-3495issn
1542-0086pii
S0006-3495(77)85587-2journal_volume
19pub_type
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