Abstract:
:In this paper we explore the properties of a mathematical model for the passive sodium permeability system of excitable membranes. This model is distinguished by the explicit inclusion of a rate constant which depends not on instantaneous voltage, but on rate of voltage change. Actually, the model is a rather modest modification of the Hodgkin-Huxley model, but displays some behaviors which the H-H model does not. Among these behaviors are a pronounced inactivation shift (for certain parameter values), a difference between inactivation time constant as measured by turning off a sodium current under sustained depolarization and as measured by double pulse experiments, skip runs under sustained current stimulation, and accommodation to slowing rising currents.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Jakobsson E,Scudiero Cdoi
10.1016/S0006-3495(75)85840-1subject
Has Abstractpub_date
1975-06-01 00:00:00pages
577-90issue
6eissn
0006-3495issn
1542-0086pii
S0006-3495(75)85840-1journal_volume
15pub_type
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