Abstract:
:The interaction between two stiff parallel DNA molecules is discussed using linear Debye-Hückel screening theory with and without inclusion of the dielectric discontinuity at the DNA surface, taking into account the helical symmetry of DNA. The pair potential furthermore includes the amount and distribution of counterions adsorbed on the DNA surface. The interaction does not only depend on the interaxial separation of two DNA molecules, but also on their azimuthal orientation. The optimal mutual azimuthal angle is a function of the DNA-DNA interaxial separation, which leads to azimuthal frustrations in an aggregate. On the basis of the pair potential, the positional and orientational order in columnar B-DNA assemblies in solution is investigated. Phase diagrams are calculated using lattice sums supplemented with the entropic contributions of the counterions in solution. A variety of positionally and azimuthally ordered phases and bundling transitions is predicted, which strongly depend on the counterion adsorption patterns.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Harreis HM,Likos CN,Löwen Hdoi
10.1016/S0006-3495(03)75092-9subject
Has Abstractpub_date
2003-06-01 00:00:00pages
3607-23issue
6eissn
0006-3495issn
1542-0086pii
S0006-3495(03)75092-9journal_volume
84pub_type
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