Abstract:
:Aromatic monocarboxylic acids are known to significantly potentiate the mechanical response of skeletal muscle fibers. In this study we investigated the effects of enantiomers of 2-(4-chlorophenoxy)propionic acid, chemically one of the simplest aromatic monocarboxylic acids with chiral properties, on mechanical threshold and charge movement in frog skeletal muscle. The R(+), but not the S(-), enantiomer lowered rheobase mechanical threshold and shifted charge movement to more negative potentials. The R(+) enantiomer also significantly slowed charge movement kinetics, with pronounced delays of the OFF charge transitions. These effects required high temperature for their production. The stereospecific actions of the R(+) enantiomer are interpreted in terms of a specific interaction of this compound at an anion-sensitive site involved in excitation-contraction coupling, most likely on the dihydropryidine-sensitive voltage sensor in the T-system.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Heiny JA,Jong D,Bryant SH,Conte-Camerino D,Tortorella Vdoi
10.1016/S0006-3495(90)82515-7subject
Has Abstractpub_date
1990-01-01 00:00:00pages
147-52issue
1eissn
0006-3495issn
1542-0086pii
S0006-3495(90)82515-7journal_volume
57pub_type
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