Abstract:
:We extend the Saffman theory of membrane hydrodynamics to account for the correlated motion of membrane proteins, along with the effect of protein concentration on that correlation and on the response of the membrane to stresses. Expressions for the coupling diffusion coefficients of protein pairs and their concentration dependence are derived in the limit of small protein size relative to the interprotein separation. The additional role of membrane viscosity as determining the characteristic length scale for membrane response leads to unusual concentration effects at large separation-the transverse coupling increases with protein concentration, whereas the longitudinal one becomes concentration-independent.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Oppenheimer N,Diamant Hdoi
10.1016/j.bpj.2009.01.020subject
Has Abstractpub_date
2009-04-22 00:00:00pages
3041-9issue
8eissn
0006-3495issn
1542-0086pii
S0006-3495(09)00421-4journal_volume
96pub_type
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