Abstract:
:This work describes the first cell-based model of tumor-induced angiogenesis. At the extracellular level, the model describes diffusion, uptake, and decay of tumor-secreted pro-angiogenic factor. At the cellular level, the model uses the cellular Potts model based on system-energy reduction to describe endothelial cell migration, growth, division, cellular adhesion, and the evolving structure of the stroma. Numerical simulations show: 1), different tumor-secreted pro-angiogenic factor gradient profiles dramatically affect capillary sprout morphology; 2), average sprout extension speeds depend on the proximity of the proliferating region to the sprout tip, and the coordination of cellular functions; and 3), inhomogeneities in the extravascular tissue lead to sprout branching and anastomosis, phenomena that emerge without any prescribed rules. This model provides a quantitative framework to test hypotheses on the biochemical and biomechanical mechanisms that control tumor-induced angiogenesis.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Bauer AL,Jackson TL,Jiang Ydoi
10.1529/biophysj.106.101501subject
Has Abstractpub_date
2007-05-01 00:00:00pages
3105-21issue
9eissn
0006-3495issn
1542-0086pii
S0006-3495(07)71120-7journal_volume
92pub_type
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