Is there a conserved interaction between cardiolipin and the type II bacterial reaction center?

Abstract:

:In a recent publication, the structural details of an interaction between the Rhodobacter sphaeroides reaction center and the anionic phospholipid diphosphatidyl glycerol (cardiolipin) were described (K. E. McAuley, P. K. Fyfe, J. P. Ridge, N. W. Isaacs, R. J. Cogdell, and M. R. Jones, 1999, Proc. Natl. Acad. Sci. U.S.A. 96:14706-14711). This was the first crystallographic description of an interaction between this biologically important lipid and an integral membrane protein and was also the first piece of evidence that the reaction center has a specific interaction with cardiolipin. We have examined the extent to which the residues that interact with the cardiolipin are conserved in other species of photosynthetic bacteria with this type of reaction center and discuss the possibility that this cardiolipin binding site is a conserved feature of these reaction centers. We look at how sequence variations that would affect the shape of the cardiolipin binding site might affect the protein-cardiolipin interaction, by modeling the binding of cardiolipin to the reaction center from Rhodopseudomonas viridis.

journal_name

Biophys J

journal_title

Biophysical journal

authors

Wakeham MC,Sessions RB,Jones MR,Fyfe PK

doi

10.1016/S0006-3495(01)76112-7

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

1395-405

issue

3

eissn

0006-3495

issn

1542-0086

pii

S0006-3495(01)76112-7

journal_volume

80

pub_type

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