Abstract:
:We investigated whether transient step reductions in divalent cations would produce detectable changes in neuronal excitability similar to those reported in the total absence of divalent cations. Using cultured chick dorsal root ganglion cells as a model system, our results indicate that a step reduction in divalent cations induces a transient inward current. This response is mediated by a tetrodotoxin-resistant, Na+-permeable, cation channel that is blocked by cadmium. This, and our observation that the response is abolished by verapamil, suggests that the current passes through calcium channels. This transient inward current was estimated to be activated by decreases in extracellular calcium ([Ca2+]o) as small as 0.5-0.8 mM and thus represents a different response from the one previously observed when steady-state [Ca2+]o levels were reduced to micromolar levels.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Hablitz JJ,Heinemann U,Lux HDdoi
10.1016/S0006-3495(86)83515-9subject
Has Abstractpub_date
1986-10-01 00:00:00pages
753-7issue
4eissn
0006-3495issn
1542-0086pii
S0006-3495(86)83515-9journal_volume
50pub_type
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