Abstract：
:Probiotics are defined as live microorganisms that, when administered in adequate amount, confer a health benefit on the host. Amongst the many benefits associated with the consumption of probiotics, modulation of the immune system has received the most attention. Several animal and human studies have provided unequivocal evidence that specific strains of probiotics are able to stimulate as well as regulate several aspects of natural and acquired immune responses. There is also evidence that intake of probiotics is effective in the prevention and/or management of acute gastroenteritis and rotavirus diarrhoea, antibiotic-associated diarrhoea and intestinal inflammatory disorders such as Crohn's disease and pouchitis, and paediatric atopic disorders. The efficacy of probiotics against bacterial infections and immunological disorders such as adult asthma, cancers, diabetes, and arthritis in humans remains to be proven. Also, major gaps exist in our knowledge about the mechanisms by which probiotics modulate immune function. Optimum dose, frequency and duration of treatment required for different conditions in different population groups also remains to be determined. Different probiotic strains vary in their ability to modulate the immune system and therefore efficacy of each strain needs to be carefully demonstrated through rigorously designed (randomised, double-blind, placebo-controlled) studies. This chapter provides an over view of the immunomodulatory effects of probiotics in health and disease, and discusses possible mechanisms through which probiotics mediate their disparate effects.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Gill H,Prasad Jdoi
10.1007/978-0-387-74087-4_17subject
Has Abstractpub_date
2008-01-01 00:00:00pages
423-54eissn
0065-2598issn
2214-8019journal_volume
606pub_type
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更新日期：1995-01-01 00:00:00
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更新日期：1996-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2003-01-01 00:00:00
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更新日期：1994-01-01 00:00:00
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更新日期：2017-01-01 00:00:00
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更新日期：2019-01-01 00:00:00
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doi：10.1007/978-1-4684-5913-5_28
更新日期：1991-01-01 00:00:00
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更新日期：2018-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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doi：
更新日期：2001-01-01 00:00:00
abstract：:Fumonisins, a group of mycotoxins produced by Fusarium moniliforme in corn, have been implicated in several animal and human diseases. F. moniliforme and the fumonisins are an area of incresing concern for corn producers and consumers. Consequently, there is interest in reducing human and animal exposure to these fung...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：1996-01-01 00:00:00
abstract：:Despite diverse and changing extracellular environments, fungi maintain a relatively constant cytosolic pH and numerous organelles of distinct lumenal pH. Key players in fungal pH control are V-ATPases and the P-type proton pump Pma1. These two proton pumps act in concert with a large array of other transporters and a...
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pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：2015-01-01 00:00:00
