Abstract：
:To identify a role for a Na:H (NHE) exchanger subtype in volume regulation in bovine corneal epithelium, we determined: 1. its sensitivity to inhibition by amiloride analogues 2. the effects of either Cl removal or hypertonicity on the intracellular pH. Our results suggest that volume regulatory responses elicited by stimulation of NHE-2 may help preserve epithelial barrier function in the face of increases in tear film osmolarity.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Reinach P,Ganapathy V,Torres-Zamorano Vdoi
10.1007/978-1-4615-2417-5_18subject
Has Abstractpub_date
1994-01-01 00:00:00pages
105-10eissn
0065-2598issn
2214-8019journal_volume
350pub_type
杂志文章abstract：:Myocardial ischemia and reperfusion cause injury to the heart in myocardial ischemic disease. Both processes increase autophagy. In this chapter, we will provide an overview of the autophagic mechanism caused by myocardial ischemia/reperfusion injury and the role of autophagy in myocardial ischemia/reperfusion injury....
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-981-15-4272-5_15
更新日期：2020-01-01 00:00:00
abstract：:The data presented in this paper support a common source for intestinal mast cells in intestinal mucosae. IMC precursors and/or mastocytopoietic factors of as yet unknown origin could be transferred by immune mesenteric lymph node (IMLN) cells of thymus-bearing mice. The differentiated locally or induced mastocytopoie...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4684-9066-4_67
更新日期：1982-01-01 00:00:00
abstract：:The revised sequence of DaaA means that the protein is 98% identical to the afimbrial adhesin regulator AFAA-III. While PapB repressed FimB OFF to ON switching in strain AAEC370A, this was not the case for DaaA. PapB, but not DaaA, reduced the level of expression of type 1 fimbriae, in static LB media. Attention is no...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/0-306-46840-9_20
更新日期：2000-01-01 00:00:00
abstract：:Since the birth of proteomics science in the 1990, the number of applications and of sample preparation methods has grown exponentially, making a huge contribution to the knowledge in life science disciplines. Continuous improvements in the sample treatment strategies unlock and reveal the fine details of disease mech...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-030-12298-0_4
更新日期：2019-01-01 00:00:00
abstract：:Diabetes is the leading cause of microalbuminuria and end-stage renal failure in industrial countries. Disruption of the filtration barrier, seen in almost all nephrotic diseases and diabetes, is the result of the loss or effacement of the podocyte foot process, notably damage of proteins within the slit diaphragm suc...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/5584_2017_62
更新日期：2017-01-01 00:00:00
abstract：:Baroreflex is involved in the regulation of arterial blood pressure (BP). An increase in BP activates vagal inhibitory pathways to decrease heart rate; a concomitant decrease in sympathetic discharge reduces vascular resistance. Both responses reduce BP towards normal value. Conversely, a decrease in BP produces oppos...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-94-007-4584-1_25
更新日期：2012-01-01 00:00:00
abstract：:In recent years, there has been a growing movement towards the use of targeted therapies in treating of atopic dermatitis (AD), parallel to that which has occurred in psoriasis. Among the systemic medications being studied are subcutaneous or intravenously administered biologic drugs targeting specific molecules such ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-64804-0_15
更新日期：2017-01-01 00:00:00
abstract：:Malignant melanoma is a highly aggressive tumour with increasing -incidence and poor prognosis in the metastatic stage. In recent years, a substantial number of reports on individual miRNAs or miRNA patterns have been published providing strong evidence that miRNAs might play an important role in malignant melanoma an...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-94-007-5590-1_6
更新日期：2013-01-01 00:00:00
abstract：:Because homeobox-containing genes play a major role in embryogenesis and tissue identity in Drosophila and because similar genes encode tissue-specific transcription factors in mammalian cells, we hypothesized that homeobox genes might plan a role in hematopoietic differentiation and lineage commitment. We therefore s...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4613-0623-8_22
更新日期：1989-01-01 00:00:00
abstract：:There is a considerable body of evidence indicating that oxidative stress is a causal factor both in lipofuscinogenesis as well as in aging. Studies on the effects of pro-oxidants and antioxidants on lipofuscin accumulation in cultured rat cardiac myocytes and human glial cells indicated that pro-oxidants accelerate w...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4899-5339-1_2
更新日期：1989-01-01 00:00:00
abstract：:As extracts from Ganoderma lucidum (G. lucidum, Lingzhi) have been reported to be an alternative adjuvant treatment for diabetes, numerous of work have been carried out on it. Among the many biologically active constituents of Ganoderma, polysaccharides, proteoglycans, proteins, and triterpenoids have been shown to ha...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-981-32-9421-9_8
更新日期：2019-01-01 00:00:00
abstract：:Before any clinical signs of diabetic retinopathy can be detected, two major histopathological lesions occur in the walls of retinal capillaries: basement membrane thickening; and loss of intramural pericytes (mural cells). A decrease in the number of pericyte to endothelial cell junctions also occurs under diabetic c...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4684-5616-5_45
更新日期：1988-01-01 00:00:00
abstract：:Nurses are a pivotal component of the translational research movement and apply scientific discoveries to the healthcare and clinical practice fields. Biobanking is also an important factor in furthering translational research by providing biospecimens and related clinical data to the research community. The effective...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-3-319-20579-3_12
更新日期：2015-01-01 00:00:00
abstract：:During the past decade the mechanism of CTL-mediated killing has been resolved into 3 steps, and its cation requirements, and general nature have been well defined. However, biochemical understanding of the CTL-target interaction has made little progress. Recently, we have developed a monoclonal antibody (MAb) which b...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4684-8959-0_27
更新日期：1982-01-01 00:00:00
abstract：:We investigated the relation between blood pressure and cerebral oxygenation (COX) immediately after exercise in ten healthy males. Subjects completed an exercise and recovery protocol while breathing either 21% (normoxia) or 14.1% (hypoxia) O2 in a randomized order. Each exercise session included four sets of cycling...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4939-3023-4_12
更新日期：2016-01-01 00:00:00
abstract：:THC, the major psychoactive component of marijuana, has been shown both in humans and experimental animals to have immunomodulatory properties. For example, marijuana smokers may show impaired immunological functions, including deficiency of blood leukocyte blastogenesis to mitogens. Detailed studies with mice have sh...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4615-1951-5_15
更新日期：1995-01-01 00:00:00
abstract：:In many fields such as data mining, machine learning, pattern recognition and signal processing, data sets containing huge number of features are often involved. Feature selection is an essential data preprocessing technique for such high-dimensional data classification tasks. Traditional dimensionality reduction appr...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4419-7046-6_10
更新日期：2011-01-01 00:00:00
abstract：:Since its inception as a scalable and cost-effective method for precise quantification of the abundance of multiple protein analytes and post-translational epitopes across large sample sets, reverse phase protein array (RPPA) has been utilized as a drug discovery tool. Key RPPA drug discovery applications include prim...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-981-32-9755-5_11
更新日期：2019-01-01 00:00:00
abstract：:Honokiol (C18H18O2) is a biphenolic natural product isolated from the bark and leaves of Magnolia plant spp. During the last decade or more, honokiol has been extensively studied for its beneficial effect against several diseases. Investigations have demonstrated that honokiol possesses anti-carcinogenic, anti-inflamm...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-41334-1_11
更新日期：2016-01-01 00:00:00
abstract：:The field of proteomics holds promise for the discovery of new biomarkers for the early detection and diagnosis of disease, molecular targets for therapy and markers for therapeutic efficacy and toxicity. A variety of proteomics approaches may be used to address these goals. Two-dimensional gel electrophoresis (2D-PAG...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4615-0081-0_7
更新日期：2003-01-01 00:00:00
abstract：:Cross sectional segments were removed from the uteri of pregnant and pseudopregnant mice and incubated in vitro with labeled amino acids. Proteins that were synthesized and secreted by these explants were separated by two-dimensional polyacrylamide gel electrophoresis and localized by fluorography. As expected, the ov...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4684-1297-0_12
更新日期：1987-01-01 00:00:00
abstract：:DES is metabolized to a number of compounds through a minimum of three main metabolic routes. These routes result in some inactivity of DES as an estrogen, but the majority appear to produce estrogenic by-products, which in some cases produce divergent in vivo and in vitro hormone activities. Therefore, if DES undergo...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-7192-6_3
更新日期：1981-01-01 00:00:00
abstract：INTRODUCTION:Ensuring the microbiological quality of textiles is an important requirement for health care facilities. The present study examines the way transport times and temperatures influence microbial growth in textiles. Therefore, the effectiveness of washing and disinfection processes has also been studied. MET...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/5584_2020_560
更新日期：2020-06-29 00:00:00
abstract：:Throughout evolution, eukaryotic cells have devised different mechanisms to cope with stressful environments. When eukaryotic cells are exposed to stress stimuli, they activate adaptive pathways that allow them to restore cellular homeostasis. Most types of stress stimuli have been reported to induce a decrease in ove...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-3-030-19966-1_6
更新日期：2019-01-01 00:00:00
abstract：:The analysis of complex biological networks has traditionally relied on decomposition into smaller, semi-autonomous units such as individual signaling pathways. With the increased scope of systems biology (models), rational approaches to modularization have become an important topic. With increasing acceptance of de f...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4419-7210-1_1
更新日期：2012-01-01 00:00:00
abstract：:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Gain-of-function mutations in KIT or platelet-derived growth factor receptor alpha (PDGFRA) drive most GISTs, and 85 % of GISTs also contain oncogenic mutations in one of two receptor tyrosine kinases. The adv...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-3-319-42316-6_9
更新日期：2016-01-01 00:00:00
abstract：:Membrane-covered polarographic sensors were designed by Leland Clark several decades ago. The membrane covering was a brilliant innovation because it provided an isolation of electrochemical elements from the external environment. These sensors have found a wide range of applications in many aspects of medicine, resea...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-0205-0_25
更新日期：2003-01-01 00:00:00
abstract：:Time-resolved near-infrared spectroscopy (TRS-NIRS) allows absolute quantitation of deoxygenated haemoglobin and myoglobin concentration ([HHb]) in skeletal muscle. We recently showed that the spatial distribution of peak [HHb] within the quadriceps during moderate-intensity cycling is reduced with progressive hypoxia...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4939-3023-4_2
更新日期：2016-01-01 00:00:00
abstract：:The extracellular calcium ([Formula: see text])-sensing receptor (CaSR) was the first GPCR identified whose principal physiological ligand is an ion, namely extracellular Ca(2+). It maintains the near constancy of [Formula: see text] that complex organisms require to ensure normal cellular function. A wealth of inform...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-94-007-2888-2_5
更新日期：2012-01-01 00:00:00
abstract：:We address here aspects of the implementation of a memory evolutive system (MES), based on the model proposed by A. Ehresmann and J. Vanbremeersch (2007), by means of a simulated network of spiking neurons with time dependent plasticity. We point out the advantages and challenges of applying category theory for the re...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-0-387-79100-5_2
更新日期：2010-01-01 00:00:00
