Abstract:
:Throughout evolution, eukaryotic cells have devised different mechanisms to cope with stressful environments. When eukaryotic cells are exposed to stress stimuli, they activate adaptive pathways that allow them to restore cellular homeostasis. Most types of stress stimuli have been reported to induce a decrease in overall protein synthesis accompanied by induction of alternative mechanisms of mRNA translation initiation. Here, we present well-studied and recent examples of such stress responses and the alternative translation initiation mechanisms they induce, and discuss the consequences of such regulation for cell homeostasis and oncogenic transformation.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Lacerda R,Menezes J,Candeias MMdoi
10.1007/978-3-030-19966-1_6subject
Has Abstractpub_date
2019-01-01 00:00:00pages
117-132eissn
0065-2598issn
2214-8019journal_volume
1157pub_type
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journal_title:Advances in experimental medicine and biology
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