Abstract:
:Progesterone is a steroid hormone whose physiological effects can affect various systems, including reproductive, immune and cardiorespiratory systems. In fact, there are growing evidences proving that progesterone is potent respiratory stimulant with therapeutic value for sleep-disordered breathing. However there is no clear understanding of how progesterone mediates its stimulant respiratory effects and alleviates apnea. Mechanistically, it was demonstrated that this hormone elicits some of its respiratory effect via the classical mechanism of the nuclear progesterone receptor (nPR), a transcription factor belonging to the super family of steroid hormone receptors. Moreover, experimental results indicate that activation of alternative non-genomic (i.e. non-nuclear) signaling pathways such as the membrane progesterone receptors (mPR) could have a key role in the regulation of the respiratory control system. We provide preliminary results suggesting an important role of mPRβ on respiratory control and ventilatory response to hypoxia in adult female mice.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Boukari R,Marcouiller F,Joseph Vdoi
10.1007/978-3-319-18440-1_30subject
Has Abstractpub_date
2015-01-01 00:00:00pages
261-7eissn
0065-2598issn
2214-8019journal_volume
860pub_type
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