Abstract：
:The quantification of tissue oxygen by frequency or time domain methods has been discussed in a number of prior publications where the meaning of the tissue hemoglobin oxygen saturation was unclear and where the CW instruments were unsuitable for proper quantitative measurements [1, 2]. The development of the IQ Phase Meter has greatly simplified and made reliable the difficult determination of precise phase and amplitude signals from brain. This contribution reports on the calibration of the instrument in model systems and the use of the instrument to measure tissue saturation (StO2) in a small animal model. In addition, a global interpretation of the meaning of tissue oxygen has been formulated based on the idea that autoregulation will maintain tissue oxygen at a fixed value over a range of arterial and venous oxygen values over the range of autoregulation. Beyond that range, the tissue oxygen is still correctly measured but, as expected, approaches the arterial saturation at low metabolic rates and the venous saturation at high metabolic rates of mitochondria.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Chance B,Ma HY,Nioka Sdoi
10.1007/978-1-4615-0075-9_2subject
Has Abstractpub_date
2003-01-01 00:00:00pages
13-8eissn
0065-2598issn
2214-8019journal_volume
530pub_type
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