Reactivity of taurine with aldehydes and its physiological role.

Abstract:

:The chemical reactions of the amino group of taurine with aldehydes were investigated. Glucose, acetaldehyde, and malondialdehyde were used as aldehydes. After taurine had reacted, the amounts of remaining taurine and aldehydes were measured, and the reactivity was evaluated. Amino acids such as glycine, alpha-alanine, and beta-alanine were compared because of their structural resemblance to each other. Taurine showed a high reactivity with each one of the aldehydes tested. It is known that protein is altered through reactions of the amino group with various aldehydes. Low density lipoprotein (LDL) was used as a model protein and the inhibiting effect of taurine against the modification of LDL by malondialdehyde was examined. It was shown that the inhibiting effects of taurine correlated with the reactivity of malondialdehyde with amino acids. Further, the taurine-glucose reaction product showed an antioxidative effect on the peroxidation of liposomes made of yolk phosphatidylcholine as a biomembrane model. The results suggest the possibility of an inhibiting effect of taurine against the modification of protein, as well as an antioxidative effect through the reactions of taurine with aldehydes in vivo.

journal_name

Adv Exp Med Biol

authors

Ogasawara M,Nakamura T,Koyama I,Nemoto M,Yoshida T

doi

10.1007/978-1-4899-1471-2_8

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

71-8

eissn

0065-2598

issn

2214-8019

journal_volume

359

pub_type

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