Synthesis and swelling properties of novel pH-sensitive poly(aspartic acid) gels.

Abstract:

:Chemically cross-linked poly(aspartic acid) (PASP) gels were prepared by the hydrolysis of poly(succinimide) (PSI). The latter was prepared by thermal polycondensation of aspartic acid. The PSI chains were cross-linked by natural amines and amino acid derivatives such as putrescin, spermine, spermidine, lysine and cystamine to obtain biodegradable, biocompatible, amino acid-based hydrogels. The volume of the synthesized unhydrolyzed PSI gels changes abruptly at a well-defined pH that results in ring opening, while the hydrolyzed gels show a volume phase transition around the pK values of PASP. The unidirectional stress-strain behavior of the gels as well as the dependence of equilibrium swelling degree on the pH was carefully studied and the most important network parameters were determined by a modified version of the Brannon-Peppas-Peppas theory.

journal_name

Acta Biomater

journal_title

Acta biomaterialia

authors

Gyenes T,Torma V,Gyarmati B,Zrínyi M

doi

10.1016/j.actbio.2007.12.004

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

733-44

issue

3

eissn

1742-7061

issn

1878-7568

pii

S1742-7061(07)00202-4

journal_volume

4

pub_type

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