Synthesis and swelling properties of novel pH-sensitive poly(aspartic acid) gels.


:Chemically cross-linked poly(aspartic acid) (PASP) gels were prepared by the hydrolysis of poly(succinimide) (PSI). The latter was prepared by thermal polycondensation of aspartic acid. The PSI chains were cross-linked by natural amines and amino acid derivatives such as putrescin, spermine, spermidine, lysine and cystamine to obtain biodegradable, biocompatible, amino acid-based hydrogels. The volume of the synthesized unhydrolyzed PSI gels changes abruptly at a well-defined pH that results in ring opening, while the hydrolyzed gels show a volume phase transition around the pK values of PASP. The unidirectional stress-strain behavior of the gels as well as the dependence of equilibrium swelling degree on the pH was carefully studied and the most important network parameters were determined by a modified version of the Brannon-Peppas-Peppas theory.


Acta Biomater


Acta biomaterialia


Gyenes T,Torma V,Gyarmati B,Zrínyi M




Has Abstract


2008-05-01 00:00:00














  • Inhibition of osteoclastogenesis by stem cell-derived extracellular matrix through modulation of intracellular reactive oxygen species.

    abstract::Decellularized extracellular matrix (ECM) derived from stem cells has been shown as a promising biomaterial for bone regeneration because of the promotion effect on osteogenesis in mesenchymal stem cells (MSCs). However, bone regeneration is also influenced by bone resorption and little is known about the effect of ce...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Li M,Chen X,Yan J,Zhou L,Wang Y,He F,Lin J,Zhu C,Pan G,Yu J,Pei M,Yang H,Liu T

    更新日期:2018-04-15 00:00:00

  • Microstructural quantification of collagen fiber orientations and its integration in constitutive modeling of the porcine carotid artery.

    abstract:BACKGROUND:Mechanical characteristics of vascular tissue may play a role in different arterial pathologies, which, amongst others, requires robust constitutive descriptions to capture the vessel wall's anisotropic and non-linear properties.Specifically, the complex 3D network of collagen and its interaction with other ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Sáez P,García A,Peña E,Gasser TC,Martínez MA

    更新日期:2016-03-01 00:00:00

  • Accelerated wound closure of pressure ulcers in aged mice by chitosan scaffolds with and without bFGF.

    abstract::Pressure ulcers are a significant healthcare concern, especially for elderly populations. Our work served to ameliorate the chronicity of these ulcers by addressing ischemia-reperfusion injury mediated by neutrophils and the concomitant loss of vasculature in these wounds. To this end, chitosan scaffolds loaded with b...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Park CJ,Clark SG,Lichtensteiger CA,Jamison RD,Johnson AJ

    更新日期:2009-07-01 00:00:00

  • Crosslinked collagen hydrogels as corneal implants: effects of sterically bulky vs. non-bulky carbodiimides as crosslinkers.

    abstract::We have previously shown that recombinant human collagen can be crosslinked with N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide (EDC) to fabricate transparent hydrogels possessing the shape and dimensions of the human cornea. These corneal implants have been tested in a Phase I human clinical study. Although these hyd...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Ahn JI,Kuffova L,Merrett K,Mitra D,Forrester JV,Li F,Griffith M

    更新日期:2013-08-01 00:00:00

  • Differences in mineral composition and morphology between men and women in aortic valve calcification.

    abstract::Aortic valve calcification leads to the deposition of calcium phosphate minerals in the extracellular matrix of the aortic valve leaflets. The mineral deposits can severely narrow the opening of the aortic valve, leading to aortic stenosis. There are no therapies to halt or slow down disease progression and the mechan...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Gourgas O,Khan K,Schwertani A,Cerruti M

    更新日期:2020-04-01 00:00:00

  • Matrix RGD ligand density and L1CAM-mediated Schwann cell interactions synergistically enhance neurite outgrowth.

    abstract::The innate biological response to peripheral nerve injury involves a complex interplay of multiple molecular cues to guide neurites across the injury gap. Many current strategies to stimulate regeneration take inspiration from this biological response. However, little is known about the balance of cell-matrix and Schw...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Romano NH,Madl CM,Heilshorn SC

    更新日期:2015-01-01 00:00:00

  • Pelvic floor muscle function recovery using biofabricated tissue constructs with neuromuscular junctions.

    abstract::Damages in pelvic floor muscles often cause dysfunction of the entire pelvic urogenital system, which is clinically challenging. A bioengineered skeletal muscle construct that mimics structural and functional characteristics of native skeletal muscle could provide a therapeutic option to restore normal muscle function...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Kim JH,Ko IK,Jeon MJ,Kim I,Vanschaayk MM,Atala A,Yoo JJ

    更新日期:2021-02-01 00:00:00

  • On the effect of temperature on the insertion of zinc into hydroxyapatite.

    abstract::Rietveld analysis of X-ray powder diffraction patterns recorded from 28 hydroxyapatite (HAp) samples containing various amounts of zinc (0, 1.6, 3.2 and 6.1wt.% Zn) and heat treated at various temperatures (between 500°C and 1100°C) has enabled the Zn insertion mechanism into the HAp crystal structure to be finely cha...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Gomes S,Nedelec JM,Renaudin G

    更新日期:2012-03-01 00:00:00

  • Evaluation of an in situ chemically crosslinked hydrogel as a long-term vitreous substitute material.

    abstract::Currently there is no material that can be used as a long-term vitreous substitute, and this remains an unmet clinical need in ophthalmology. In this study, we developed an injectable, in situ chemically crosslinked hydrogel system and evaluated it in a rabbit model. The system consisted of two components, both based ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Tao Y,Tong X,Zhang Y,Lai J,Huang Y,Jiang YR,Guo BH

    更新日期:2013-02-01 00:00:00

  • An overview of thin film nitinol endovascular devices.

    abstract::Thin film nitinol has unique mechanical properties (e.g., superelasticity), excellent biocompatibility, and ultra-smooth surface, as well as shape memory behavior. All these features along with its low-profile physical dimension (i.e., a few micrometers thick) make this material an ideal candidate in developing low-pr...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章,评审


    authors: Shayan M,Chun Y

    更新日期:2015-07-01 00:00:00

  • Superior calvarial bone regeneration using pentenoate-functionalized hyaluronic acid hydrogels with devitalized tendon particles.

    abstract::Traumatic brain injury (TBI) is a life-threatening condition defined by internal brain herniation. Severe TBI is commonly treated by a two-stage surgical intervention, where decompressive craniectomy is first conducted to remove a large portion of calvarial bone and allow unimpeded brain swelling. In the second surger...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Townsend JM,Andrews BT,Feng Y,Wang J,Nudo RJ,Van Kampen E,Gehrke SH,Berkland CJ,Detamore MS

    更新日期:2018-04-15 00:00:00

  • Biodegradable and adjustable sol-gel glass based hybrid scaffolds from multi-armed oligomeric building blocks.

    abstract::Biodegradability is a crucial characteristic to improve the clinical potential of sol-gel-derived glass materials. To this end, a set of degradable organic/inorganic class II hybrids from a tetraethoxysilane(TEOS)-derived silica sol and oligovalent cross-linker oligomers containing oligo(d,l-lactide) domains was devel...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Kascholke C,Hendrikx S,Flath T,Kuzmenka D,Dörfler HM,Schumann D,Gressenbuch M,Schulze FP,Schulz-Siegmund M,Hacker MC

    更新日期:2017-11-01 00:00:00

  • Electrospun fibrous scaffolds with continuous gradations in mineral contents and biological cues for manipulating cellular behaviors.

    abstract::Challenges remain in the generation of heterogeneous tissues and the repairing of interfacial tissue between soft and hard tissues. The development of tissue engineering scaffolds with gradients in composition, structure, mechanical and chemical properties is essential to modulate cellular behaviors in a graded way an...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Zou B,Liu Y,Luo X,Chen F,Guo X,Li X

    更新日期:2012-04-01 00:00:00

  • X-ray and NIR light dual-triggered mesoporous upconversion nanophosphor/Bi heterojunction radiosensitizer for highly efficient tumor ablation.

    abstract::Developing a multi-functional radiosensitizer with high efficiency and low toxicity remains challenging. Herein, we report a mesoporous heterostructure radiosensitizer (UCNP@NBOF-FePc-PFA) containing Lu-based upconversion nanophosphor (UCNP) and Bi-based nanomaterial loaded with iron phthalocyanine for X-ray and NIR l...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Liu J,Zhang J,Huang F,Deng Y,Li B,Ouyang R,Miao Y,Sun Y,Li Y

    更新日期:2020-09-01 00:00:00

  • Structure and composition of the tunic in the sea pineapple Halocynthia roretzi: A complex cellulosic composite biomaterial.

    abstract::Biological organisms produce high-performance composite materials, such as bone, wood and insect cuticle, which provide inspiration for the design of novel materials. Ascidians (sea squirts) produce an organic exoskeleton, known as a tunic, which has been studied quite extensively in several species. However, currentl...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Song G,Delroisse J,Schoenaers D,Kim H,Nguyen TC,Horbelt N,Leclère P,Hwang DS,Harrington MJ,Flammang P

    更新日期:2020-07-15 00:00:00

  • Cell sheet mechanics: How geometrical constraints induce the detachment of cell sheets from concave surfaces.

    abstract::Despite of the progress made to engineer structured microtissues such as BioMEMS and 3D bioprinting, little control exists how microtissues transform as they mature, as the misbalance between cell-generated forces and the strength of cell-cell and cell-substrate contacts can result in unintended tissue deformations an...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Yamashita T,Kollmannsberger P,Mawatari K,Kitamori T,Vogel V

    更新日期:2016-11-01 00:00:00

  • Nanocomposite hydrogels stabilized by self-assembled multivalent bisphosphonate-magnesium nanoparticles mediate sustained release of magnesium ion and promote in-situ bone regeneration.

    abstract::Hydrogels are appealing biomaterials for applications in regenerative medicine due to their tunable physical and bioactive properties. Meanwhile, therapeutic metal ions, such as magnesium ion (Mg2+), not only regulate the cellular behaviors but also stimulate local bone formation and healing. However, the effective de...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Zhang K,Lin S,Feng Q,Dong C,Yang Y,Li G,Bian L

    更新日期:2017-12-01 00:00:00

  • Flexible and elastic porous poly(trimethylene carbonate) structures for use in vascular tissue engineering.

    abstract::Biocompatible and elastic porous tubular structures based on poly(1,3-trimethylene carbonate), PTMC, were developed as scaffolds for tissue engineering of small-diameter blood vessels. High-molecular-weight PTMC (M(n) = 4.37 x 10(5)) was cross-linked by gamma-irradiation in an inert nitrogen atmosphere. The resulting ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Song Y,Kamphuis MM,Zhang Z,Sterk LM,Vermes I,Poot AA,Feijen J,Grijpma DW

    更新日期:2010-04-01 00:00:00

  • Photopatterning of vascular endothelial growth factor within collagen-glycosaminoglycan scaffolds can induce a spatially confined response in human umbilical vein endothelial cells.

    abstract::Biomolecular signals within the native extracellular matrix are complex, with bioactive factors found in both soluble and sequestered states. In the design of biomaterials for tissue engineering applications it is increasingly clear that new approaches are required to locally tailor the biomolecular environment surrou...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Alsop AT,Pence JC,Weisgerber DW,Harley BAC,Bailey RC

    更新日期:2014-11-01 00:00:00

  • The effect of pore diameter on neo-tissue formation in electrospun biodegradable tissue-engineered arterial grafts in a large animal model.

    abstract::To date, there has been little investigation of biodegradable tissue engineered arterial grafts (TEAG) using clinically relevant large animal models. The purpose of this study is to explore how pore size of electrospun scaffolds can be used to balance neoarterial tissue formation with graft structural integrity under ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Matsuzaki Y,Iwaki R,Reinhardt JW,Chang YC,Miyamoto S,Kelly J,Zbinden J,Blum K,Mirhaidari G,Ulziibayar A,Shoji T,Breuer CK,Shinoka T

    更新日期:2020-10-01 00:00:00

  • A bioinspired hyperthermic macrophage-based polypyrrole-polyethylenimine (Ppy-PEI) nanocomplex carrier to prevent and disrupt thrombotic fibrin clots.

    abstract::Fibrinolytic treatments for venous or arterial thrombotic syndromes using systemic administration of thrombolytics, such as streptokinase, can induce life-threatening bleeding complications. In this study, we offer the first proof of concept for a targeted photothermal fibrin clot prevention and reduction technology u...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Burnouf T,Chen CH,Tan SJ,Tseng CL,Lu KY,Chang LH,Nyambat B,Huang SC,Jheng PR,Aditya RN,Mi FL,Chuang EY

    更新日期:2019-09-15 00:00:00

  • Cell spreading correlates with calculated logP of amino acid-modified surfaces.

    abstract::The interactions of cells with synthetic surfaces are a critical factor in biomaterials design and it would be invaluable if these interactions could be precisely controlled and predicted. Hydrophobicity or lipophilicity of the surface is commonly used to rationalize cell attachment to materials. In the pharmaceutical...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Rawsterne RE,Todd SJ,Gough JE,Farrar D,Rutten FJ,Alexander MR,Ulijn RV

    更新日期:2007-09-01 00:00:00

  • Surface modifications by gas plasma control osteogenic differentiation of MC3T3-E1 cells.

    abstract::Numerous studies have shown that the physicochemical properties of biomaterials can control cell activity. Cell adhesion, proliferation, differentiation as well as tissue formation in vivo can be tuned by properties such as the porosity, surface micro- and nanoscale topography and chemical composition of biomaterials....

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Barradas AM,Lachmann K,Hlawacek G,Frielink C,Truckenmoller R,Boerman OC,van Gastel R,Garritsen H,Thomas M,Moroni L,van Blitterswijk C,de Boer J

    更新日期:2012-08-01 00:00:00

  • A new approach in biomimetic synthesis of calcium phosphate coatings using lactic acid-Na lactate buffered body fluid solution.

    abstract::The main objective of this study was to investigate calcium phosphate (CaP) coatings on Ti6Al4V substrates by using the biomimetic technique. To this purpose, a new solution was developed to coat CaP on Ti6Al4V alloy substrates. The newly formulated body fluid (Lac-SBF) contained appropriate amounts of sodium lactate ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Pasinli A,Yuksel M,Celik E,Sener S,Tas AC

    更新日期:2010-06-01 00:00:00

  • bFGF-containing electrospun gelatin scaffolds with controlled nano-architectural features for directed angiogenesis.

    abstract::Current therapeutic angiogenesis strategies are focused on the development of biologically responsive scaffolds that can deliver multiple angiogenic cytokines and/or cells in ischemic regions. Herein, we report on a novel electrospinning approach to fabricate cytokine-containing nanofibrous scaffolds with tunable arch...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Montero RB,Vial X,Nguyen DT,Farhand S,Reardon M,Pham SM,Tsechpenakis G,Andreopoulos FM

    更新日期:2012-05-01 00:00:00

  • Quantifying stent-induced damage in coronary arteries by investigating mechanical and structural alterations.

    abstract::Vascular damage develops with diverging severity during and after percutaneous coronary intervention with stent placement and is the prevailing stimulus for in-stent restenosis. Previous work has failed to link mechanical data obtained in a realistic in vivo or in vitro environment with data collected during imaging p...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Geith MA,Nothdurfter L,Heiml M,Agrafiotis E,Gruber M,Sommer G,Schratzenstaller TG,Holzapfel GA

    更新日期:2020-10-15 00:00:00

  • Tuning the bioactivity of bone morphogenetic protein-2 with surface immobilization strategies.

    abstract::Bone morphogenetic protein-2 (BMP-2) involved therapy is of great potential for bone regeneration. However, its clinical application is restricted due to the undesirable bioactivity and relevant complications in vivo. Immobilization of recombinant BMP-2 (rhBMP-2) is an efficient strategy to mimic natural microenvironm...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Chen R,Yu Y,Zhang W,Pan Y,Wang J,Xiao Y,Liu C

    更新日期:2018-10-15 00:00:00

  • Intrinsic immunogenicity of rapidly-degradable polymers evolves during degradation.

    abstract:UNLABELLED:Recent studies reveal many biomaterial vaccine carriers are able to activate immunostimulatory pathways, even in the absence of other immune signals. How the changing properties of polymers during biodegradation impact this intrinsic immunogenicity is not well studied, yet this information could contribute t...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Andorko JI,Hess KL,Pineault KG,Jewell CM

    更新日期:2016-03-01 00:00:00

  • Cell adhesion and mechanical properties of a flexible scaffold for cardiac tissue engineering.

    abstract::Cardiac tissue engineering is focused on obtaining functional cardiomyocyte constructs to provide an alternative to cellular cardiomyoplasty. Mechanical stimuli have been shown to stimulate protein expression and the differentiation of mammalian cells from contractile tissues. Our aim was to obtain a flexible scaffold...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Hidalgo-Bastida LA,Barry JJ,Everitt NM,Rose FR,Buttery LD,Hall IP,Claycomb WC,Shakesheff KM

    更新日期:2007-07-01 00:00:00

  • Immobilization of glycoproteins, such as VEGF, on biodegradable substrates.

    abstract::Attachment of growth factors to biodegradable polymers, such as poly(lactide-co-glycolide) (PLGA), may enhance and/or accelerate integration of tissue engineering scaffolds. Although proteins are commonly bound via abundant amino groups, a more selective approach may increase bioactivity of immobilized molecules. In t...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Sharon JL,Puleo DA

    更新日期:2008-07-01 00:00:00