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Binding of misonidazole to hypoxic cells in monolayer and spheroid culture: evidence that a side-chain label is bound as efficiently as a ring label.

Abstract：

:The binding of ring-labelled and side-chain labelled misonidazole to hypoxic cells in monolayer and spheroid cultures of mammalian cells has been compared. The kinetics and patterns of binding for the two labelled compounds are indistinguishable. This finding has implications for the mechanism of binding and for the design of misonidazole analogues which might be used to identify hypoxic zones in tumours.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Raleigh JA,Franko AJ,Koch CJ,Born JL

doi

10.1038/bjc.1985.33

subject

Has Abstract

pub_date

1985-02-01 00:00:00

pages

229-35

issue

2

eissn

0007-0920

issn

1532-1827

journal_volume

51

pub_type

杂志文章

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