Abstract:
:Transmission of arenaviruses from rodent hosts to humans is generally thought to occur through inhalation or ingestion of dust or droplets containing viral particles. Here we demonstrate that two identified arenavirus receptors, alpha-dystroglycan (alpha-DG) and transferrin receptor 1 (TfR1), are expressed in polarized human airway epithelia. Lymphocytic choriomeningitis virus strains with high or low alpha-DG affinity and Junin virus, which binds TfR1, efficiently infected polarized epithelia only when applied to the basolateral surface or when injury compromised tight junction integrity. Viral egress from infected epithelia exhibited basolateral polarity. This study demonstrates that respiratory entry of arenaviruses occurs via basolateral receptors.
journal_name
J Viroljournal_title
Journal of virologyauthors
Dylla DE,Michele DE,Campbell KP,McCray PB Jrdoi
10.1128/JVI.00100-08subject
Has Abstractpub_date
2008-06-01 00:00:00pages
6034-8issue
12eissn
0022-538Xissn
1098-5514pii
JVI.00100-08journal_volume
82pub_type
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pub_type: 杂志文章
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
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