[Old age and the kidneys].

Abstract:

:Age-related changes in renal morphology and function cannot be regarded physiological. The number of glomeruli falls, sclerotic glomeruli and aglomerular arterioles develop. Besides tubular atrophy interstitial fibrosis is often seen, and the age-related vascular changes strongly affect the kidneys. Renal blood flow and GFR decrease, without concomitant changes in se-creatinine. Disorders of tubular transport manifest mainly in salt- and water-excretion and lead to hyposthenuria. The pathogenesis of these age-related changes is not fully understood. Nevertheless, such changes impair the excretory functions and the pharmacokinetics of drugs. In real chronic renal failure other functions (erythropoietin production, vitamin-D, Ca and P metabolism) are also impaired. Due to more frequent occurrence of systemic diseases (diabetes, hypertension, etc.) in the elderly, real chronic renal failure is also more common, and various forms of acute renal failure develop more easily.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Balázs E,Ruszwurm A,Székely M,Wittmann I,Nagy J

doi

10.1556/OH.2008.28362

subject

Has Abstract

pub_date

2008-04-27 00:00:00

pages

789-94

issue

17

eissn

0030-6002

issn

1788-6120

pii

W00463492HN774VT

journal_volume

149

pub_type

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