[Bicentennial of catalase research, 1818-2018].

Abstract:

:L. J. Thénard and J. L. Gay-Lussac discovered hydrogen peroxide in 1818. Later, Thénard noticed that animal and plant tissues decompose hydrogen peroxide. The substance which is responsible for this reaction was named as catalase by O. Loew in 1900. The catalase enzyme was regarded as a diagnostic and a tumour marker in the late years of the 19th century and in the early years of the 20th century. Acatalasemia, an inherited deficiency of enzyme catalase, was studied in Japan, Switzerland and Hungary. The recent findings on catalase are focusing on the effects of reactive oxygen species and on the association of acatalasemia and diabetes mellitus. Orv Hetil. 2018; 159(24): 959-964. :Absztrakt: L. J. Thénard és J. L. Gay-Lussac francia tudósok 1818-ban fedezték fel a hidrogén-peroxidot. Thénard megfigyelte, hogy a növényi és állati szövetek a hidrogén-peroxidot bontják. O. Loew 1900-ban kataláznak (catalase) nevezte azt az anyagot, amelynek tulajdonítható a hidrogén-peroxid bontása oxigénné és vízzé. A korai kutatások a kataláznak diagnosztikai és tumormarkeri (toxohormon) jelentőséget tulajdonítottak. Az acatalasaemiának mint örökletes katalázhiánynak 3 típusa (japán, svájci és magyar) vált ismertté. A katalázzal foglalkozó legújabb közlemények főbb területei az oxigénből képződő szabad gyökök hatásainak vizsgálata, valamint az acatalasaemia és a diabetes kapcsolata. Orv Hetil. 2018; 159(24): 959–964.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Góth L

doi

10.1556/650.2018.31096

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

959-964

issue

24

eissn

0030-6002

issn

1788-6120

journal_volume

159

pub_type

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