Abstract：
:Systemic lupus erythematosus (SLE) is an autoimmune disorder involving different organs and organ systems with consequent characteristic clinical and serologic symptoms. Despite of the improvement in lupus survival, approximately 10-20% of patients do not respond to traditional immune suppressive therapies. Relapses are more frequent; e.g. after cyclophosphamide therapy diffuse proliferative nephritis flares in 1/3 of patients. Different immune competent cells and inflammatory mediators participate in the pathogenesis of SLE involving both the adaptive and innate immunity. Several pathogenic elements and mechanisms may serve as therapeutic targets, consequently. Authors summarize novel therapeutic possibilities and their mechanisms regarding the pathogenesis of SLE. Immune modulation of B and T cells, co-stimulatory pathways, cytokine network, soluble mediators and autologous hemopoietic stem cell transplantation are discussed.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Bazsó A,Poór G,Gergely P,Kiss Edoi
10.1556/OH.2010.28863subject
Has Abstractpub_date
2010-05-02 00:00:00pages
735-40issue
18eissn
0030-6002issn
1788-6120pii
K2316V01Q72K0P77journal_volume
151pub_type
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