Abstract：
:The authors report a comparative study on the effects of ketotifen and oxatomide on repeated provocation of the skin and the nasal mucosa in 16 children (4 girls and 12 boys, average age 12.0 +/- 3.25 yr) with diagnosed seasonal allergic rhinitis. Preceding and following a 4-week ketotifen or oxatomide treatment, a quantitative prick skin test was performed and evaluated by planimetry and a specific nasal provocation (SNP) was performed and objectivated by rhinothermometry. Both the oedematous skin reactions induced by histamine and allergen and the clinical and thermal scores obtained by direct observation of the shock organ (SNP) were decreased more strongly by ketotiten than by oxatomide. The results of preseasonal in vivo pharmacodynamic studies are expected to permit more effective, individual medication before the pollen season or at the first sign of the symptoms.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Bittera I,Kadocsa E,Gyurkovits Ksubject
Has Abstractpub_date
1990-02-18 00:00:00pages
355-8issue
7eissn
0030-6002issn
1788-6120journal_volume
131pub_type
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