Abstract:
:The DNA (chip) technology, emerged in the last two years, provides an incredible technical development in rapid and automatised performance of genetic identification. The principle of procedure is, that by series of photolitographic and chemical steps on solid-phase of a small surface relatively dense oligonucleotide arrays can be generated. The oligonucleotides produced by the computer-directed in-situ microfabrication may bind complementary fluorescent-labeled DNA fragments from the unknown sample. After scanning, the registered position of positive signals provide information on the identity of DNA fragments. By this novel approach not only DNA sequencing can be performed, but genetic errors of known genes, presence of infectious organisms and the typing of genetic markers (such as HLA) used for transplantation and forensic medicine can be determined. The DNA-chip technology is a revolutionary new milestone in genetic diagnose.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Falus A,Váradi A,Raskó Isubject
Has Abstractpub_date
1998-04-19 00:00:00pages
957-60issue
16eissn
0030-6002issn
1788-6120journal_volume
139pub_type
杂志文章相关文献
ORVOSI HETILAP文献大全abstract:INTRODUCTION:Outcome of arterial switch operation for transposition of the great arteries with/without ventricular septal defect is a service key-performance-indicator. AIM:The aim of the authors was to assess patient characteristics and parameters in the perioperative course. METHOD:In the setting of a newly-establi...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2015.30176
更新日期:2015-06-21 00:00:00
abstract::After bone marrow transplantation, a prolonged dysregulation of humoral immunity, including restricted electrophoretic heterogeneity of serum immunoglobulins and the appearance of homogeneous immunoglobulin components, can be observed. The current study was undertaken to characterize further and define the posttranspl...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2001-02-11 00:00:00
abstract::Tumoral calcinosis is a distinct entity, which is rarely seen in Europe and North America but much more common in black Africans. Typical symptoms are calcified nodules, which grow while remaining asymptomatic and are found in the tissues adjacent to the large joints of the body. Histologically there is collagen necro...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1995-06-25 00:00:00
abstract::Non alcoholic fatty liver disease is the hepatic manifestation of metabolic syndrome, and the most common liver disease. Its more aggressive form is the non alcoholic steatohepatitis. Multiple genetic and environmental factors lead to the accumulation of triglicerides and the inflammatory cascade. High fat diet, obesi...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/650.2017.30775
更新日期:2017-06-01 00:00:00
abstract::Polycystic ovary syndrome is recognized as the most common hormonal and metabolic disorder of women. This heterogeneous endocrinopathy characterized by clinical and/or biochemical hyperandrogenism, oligo- or amenorrhoea, anovulatory infertility, and polycystic ovarian morphology. The prevalence, clinical feature and t...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2014.29941
更新日期:2014-07-27 00:00:00
abstract::May-Thurner syndrome, a pelvic vein congenital anomaly is the consequence of compression of the left common iliacal vein by the overlying right common iliacal artery that results in an increased risk for ileofemoral deep vein thrombosis. Authors present a case of a young female with aberration of the pelvic vein, who ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2011.28998
更新日期:2011-01-23 00:00:00
abstract::Capgras symptom is characterized by the delusional belief that a person significant to the patient has been replaced by a 'double' or 'impostor'. Capgras symptom was discussed to be associated with violent behavior. We report here the cases of two male patients with schizophrenia paranoid type, where parricide was con...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2019.31476
更新日期:2019-10-01 00:00:00
abstract::The aim of the retrospective study was to analyse the frequency of polyps, anamnestic data and the result of histological examination overviewing 163 polyps which was find during 1900 hysteroscopy. In the history of patients dilatation and curettage was find in 22% one time and in 6.6% two times, but the polyps were r...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1999-09-12 00:00:00
abstract:INTRODUCTION:Most human parechovirus (HPeV, family Picornaviridae) infections are asymptomatic but may cause gastroenteritis in children. New reports show that HPeVs can be associated with severe central nervous system symptoms and sepsis-like syndromes in infants. The clinical significance of HPeVs in Hungary has not ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2019.31304
更新日期:2019-03-01 00:00:00
abstract:INTRODUCTION:Human metapneumovirus was identified in 2001 as a respiratory-tract pathogen that has been classified as a new genera in family Paramyxoviridae. AIMS:Molecular detection of human metapneumovirus in Hungary. MATERIALS AND METHODS:Human metapneumovirus was identified in nasopharyngeal aspirate amplificatio...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2006-12-03 00:00:00
abstract::The redox homeostasis of patients with inflammatory bowel disease is not balanced because of malnutrition and malabsorption. The seriousness of this illness often hinders the intake and use of bioactive agents. We have just a small amount of knowledge about how patients can get access to these important materials. The...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2006-06-11 00:00:00
abstract:INTRODUCTION:In single-payer health care financing systems data extracted from hospital report forms submitted for reimbursement purposes may be used for epidemiological investigations. AIM:Based on data submitted by 14 neurological wards in Central Hungary the authors examined the reliability of these reports. METHO...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2015.30258
更新日期:2015-09-20 00:00:00
abstract::Neuroendocrine neoplasms belong to the group of rare tumours. Their clinical importance may be highlighted by their high prevalence despite low incidence. Since survival rate is similar to other progressive neoplastic diseases in metastatic cases, early recognition and appropriate therapy of these neoplasms are equall...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2013.29716
更新日期:2013-09-29 00:00:00
abstract:UNLABELLED:In daily practice mycotic infections of the CNS have become more and more frequent. The main causes are the wide-ranging use of corticosteroids, immunosuppressive, cytostatic drugs and antibiotics, the spreading of AIDS, the increasing number of surviving immature newborns. To illustrate the diagnostic diffi...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2009.28657
更新日期:2009-07-19 00:00:00
abstract::Authors examined the frequency of operative intervention in the uterine cavity, becoming inevitably necessary in late puerperium, in 28,835 mothers divided in 3 groups. In group A the controlling of the placental phase was realised in conservative, exspective way; manual or instrumental intervention in the uterine cav...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1992-02-25 00:00:00
abstract:INTRODUCTION:In their previous works, the authors reported findings from familial hematologic malignancies in Szabolcs-Szatmár-Bereg county, Hungary. So far there are no other studies on this topic available in Hungary. AIM:Detailed analysis of epidemiologic features of hematologic malignancies of siblings. METHOD:Du...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2017.30830
更新日期:2017-08-01 00:00:00
abstract:UNLABELLED:The authors summarize the present knowledge on arrhythmogenic right ventricular cardiomyopathy/dysplasia. Limited data are available about natural history of asymptomatic patients with arrhythmogenic right ventricle cardiomyopathy/dysplasia, who have a ventricular tachycardia during exercise test. A 25-year ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2010.28995
更新日期:2010-12-26 00:00:00
abstract:INTRODUCTION:The reason for unsuccessful tumor chemotherapy is related to multidrug resistance. An important factor is the overexpression of efflux pumps, such as P-glycoprotein. AIM:Amino- and amide-substituted steroid compounds and phenothiazine derivatives were investigated in tumor models in vitro. METHOD:The inh...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2016.30536
更新日期:2016-09-01 00:00:00
abstract::Of 15,000 post-mortem examinations performed in a general hospital between 1977-85 primary symmetric intracerebral calcification i. e. Fahr's disease was found in 4 cases. The pathological characteristics of the cases are described and the clinical, radiological and endocrinological aspects of the disease are discusse...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1989-01-08 00:00:00
abstract::During the last years, interventional radiological treatment of hepatocellular cancer has changed dramatically. The percutaneous ethanol infiltration is partly replaced by thermoablative methods, mainly by radiofrequency ablation. Cooled-tip electrodes and volumetric therapy planning increased the treatment success. E...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2010.28914
更新日期:2010-07-25 00:00:00
abstract:UNLABELLED:In nonvalvular atrial fibrillation stroke prevention by anticoagulation is clearly recommended by evidence based medicine. Underusage of coumarin treatment however is a general problem. The aim of this study was the analysis of prehospital and hospital practice of anticoagulant therapy in a Hungarian cohort....
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2004-03-07 00:00:00
abstract::Myotonic dystrophy is one of the most common, autosomal dominantly inherited adult-onset muscle disorders. Two types of the disease are known: type 1 is characterized by distal weakness and myotonia, but type 2 is associated with proximal weakness and milder clinical course. It is also called as Steinert Disease, whic...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2019.31505
更新日期:2019-09-01 00:00:00
abstract::Myocardial infarction became more frequent mainly in the developed countries in the past decades. Beside the pharmacological (thrombolysis, beta-blockers, ACE-inhibitors, antiplatelet- and lipid-lowering drugs, etc.) and interventional (percutaneous coronary intervention, intraaortic balloon pump, resynchronization th...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:2005-05-15 00:00:00
abstract::Introduction: Autologous hemopoietic stem cell transplantation remains a promising therapy in certain malignant and non-malignant conditions. The procedure, however, will increase the risk of complications, most notably early and late infections. Aim: To analyze the frequency and spectrum of pathogens in early (<+100 ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2020.31638
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Discrimination and classification of colorectal diseases (adenoma, colorectal cancer, inflammatory bowel disease) using biopsy samples and expression microarrays, has not been solved yet, nevertheless, it can contribute to the understanding of the colonic diseases. METHODS:Total ribonucleic acid was extract...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2007.28157
更新日期:2007-11-04 00:00:00
abstract::Amantadine prophylaxis was performed in 91 patients during influenza A epidemics. It was used for patients with chronic heart, pulmonary and metabolic disease, for immundeficienty and elderly patients. Patients with gravidity, lactation, epilepsy, peptid ulcer or serious liver disorder were excluded from prophylaxis. ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1996-01-28 00:00:00
abstract:INTRODUCTION:Early diagnosis of sex chromosome abnormalities is important because of prevention, family planning and optimal therapy. AIM:Investigation of the relationship between phenotype, age at time of diagnosis and therapeutic options in sex chromosome aberrations. METHOD:Processing data of 51 children with sex ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2018.31081
更新日期:2018-07-01 00:00:00
abstract:INTRODUCTION:Burnout is one of the most challenging questions of the healthcare systems in the 21st century. AIM:The aim of this study was to analyze the Hungarian physicians' burnout and its associations with workload factors (work hours, shift work, multiple workplaces). METHOD:Data of this representative, cross-se...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2015.30121
更新日期:2015-04-05 00:00:00
abstract::After a thourough development phase, a new system of health financing was introduced in Hungary in 1993. One of the cornerstones of the system was the financing of acute hospital care through Diagnosis-Related Groups (DRGs). This method was part of a comprehensive healthcare model, elaborated and published around 1990...
journal_title:Orvosi hetilap
pub_type: 历史文章,杂志文章,评审
doi:10.1556/650.2015.30195
更新日期:2015-07-19 00:00:00
abstract::One hundred and eleven consecutive patients with highgrade non-Hodgkin's lymphoma treated in three centres between 1983 and 1988 were analysed to assess the efficacy of different types of chemotherapy. The median age at presentation was 56.9 +/- 16.6 years. According to the Kiel classification histological subtypes we...
journal_title:Orvosi hetilap
pub_type: 临床试验,杂志文章,多中心研究,评审
doi:
更新日期:1991-05-26 00:00:00