Abstract：
:A 7-valent pneumococcal polysaccharide-protein conjugate vaccine (PCV7) was licensed in the United States of America in 2000, but no comprehensive postmarketing review of safety has been carried out. We conducted a systematic review of the safety of PCV7 and other pneumococcal conjugate vaccines. A total of 42 studies were included in the review. Reactogenicity data from some randomized trials suggest that PCV7 may result in more local reactions and fever than certain comparison vaccines. However, the reactions were mild and self-limited, and PCV7 did not carry an increased risk of severe injection-site reactions or high fever. Some, although not all, of the randomized trials in children found that mild local and systemic reactions associated with PCV7 may increase with the number of doses, at least over the three-dose primary series. In addition, PCV7 and other pneumococcal conjugate vaccines were found to have tolerable reactogenicity in Native American and African populations and in medically high-risk groups for which pneumococcal vaccination is recommended. Two of the largest studies of PCVs, one involving PCV7 and the other, PCV9, found a statistically significant increased risk of hospitalization for reactive airway disease, including asthma. Another large trial of PCV9, however, did not find an increased risk of asthma. In conclusion, this review of the evidence did not identify any major safety problems with PCV7 or any other pneumococcal conjugate vaccine, with the possible exception of reactive airway disease, which may bear further scrutiny as additional data become available.
journal_name
Bull World Health Organjournal_title
Bulletin of the World Health Organizationauthors
Destefano F,Pfeifer D,Nohynek Hdoi
10.2471/blt.07.048025subject
Has Abstractpub_date
2008-05-01 00:00:00pages
373-80issue
5eissn
0042-9686issn
1564-0604pii
S0042-96862008000500015journal_volume
86pub_type
杂志文章,评审abstract：:To assess its potential applications in plague surveillance and control programmes, an enzyme-linked immunosorbent assay (ELISA) that captures the specific Yersinia pestis F1 antigen was used to determine the amounts of this antigen present in samples of blood and spleens from laboratory rats with acute plague, in the...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:An epidemic of poliomyelitis took place in British Guiana during the winter of 1962-63. A total of 485 paralytic cases occurred over a 10-week period, 90% in children under 5 years of age.The attack rate for the total population of more than half-a-million persons was 86.5 per 100 000. Type 1 poliovirus was isolated f...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1965-01-01 00:00:00
abstract：OBJECTIVE:To increase case-finding of infection with human immunodeficiency virus (HIV) in Zambia and their referral to HIV care and treatment by supplementing existing client-initiated voluntary counselling and testing (VCT), the dominant mode of HIV testing in the country. METHODS:Lay counsellors offered provider-in...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.10.084442
更新日期：2011-05-01 00:00:00
abstract：:Simultaneously with the development of vaccines against diphtheria, the authors and their colleagues have studied the biological properties of the causative agent, Corynebacterium diphtheriae, and its role in the development of epidemics. This study has been made possible by the development of a lysotyping scheme for ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1966-01-01 00:00:00
abstract：OBJECTIVE:To assess the usefulness of the general framework of the smoking epidemic. METHODS:We use lung cancer mortality as an indicator for smoking intensity and employ an age-cohort model to accommodate the long-lasting and cumulative effects. RESULTS:Dutch males have higher risks than Danish males, but the risks ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:For 164 days mature chickens received a daily diet containing 40 g of wheat treated with organomercurial fungicide and 80 g of untreated diet. A control group received 120 g of normal diet daily. The experimental group was then split - half receiving the same diet for a further 155 days, by which time all had been kil...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：OBJECTIVE:To derive regional weight-for-age growth references to help optimize age-based dosing of antimalarials in Africa, the Americas, South-East Asia and the Western Pacific. METHODS:A weight-for-age database was constructed from pre-existing population-based anthropometric data obtained from household surveys and...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.14.139113
更新日期：2015-02-01 00:00:00
abstract：:WHO's reference protocol for post-exposure rabies vaccination advises five intramuscular injections on days 0, 3, 7, 14, and 30; in addition, rabies immunoglobulins (RIG) must be given to serious cases of exposure (grade III severity). Some studies indicate that these immunoglobulins suppress the immunogenicity of rab...
journal_title：Bulletin of the World Health Organization
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1998-01-01 00:00:00
abstract：:In serological tests for syphilis, leprosy sera often give biologically false positive reactions. These may be due to the presence of non-specific elements-for example, the ubiquitous lipid antibodies-in the leprosy sera; or they may be the result of errors in technique or unfavourable working conditions in the labora...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1960-01-01 00:00:00
abstract：:The nature of psychiatric disorders in tropical regions is affected much more by the effect on the patient of certain environmental and cultural factors than by any specific features of tropical diseases. In places where the standards of health care and health education are not yet fully developed, abnormalities of ph...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:Teguest Guerma talks to Gary Humphreys about her career in public health, and her commitment to training midwives in Ethiopia. ...
journal_title：Bulletin of the World Health Organization
pub_type： 传,历史文章,面试,新闻
doi：10.2471/BLT.19.030919
更新日期：2019-09-01 00:00:00
abstract：:A case-control study was conducted in Yaoundé, United Republic of Cameroon, to evaluate the hypothesis that intramuscular inoculations predisposed young children to paralysis if they were later exposed to poliomyelitis virus. Thirty-three cases with lower motor neuron disease and 66 neighbourhood controls were studied...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Three methods were used to measure the level of transmission of infections of Schistosoma mansoni on an irrigated sugar estate in northern Tanzania. The studies were carried out over a period of 3 years, during a programme for the control of the host snail Biomphalaria pfeifferi. During the second and third years a ma...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1972-01-01 00:00:00
abstract：:The dynamics of transmission of disease agents by vectors depends, in part, on the probability of host-vector contact, which can vary with fluctuations of both host and vector. As important as seasonal variations is 24-hour periodicity in activity. Periodicity in the landing of males and females of Aedes aegypti on ma...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1973-05-01 00:00:00
abstract：:Using a sexually transmitted diseases simulation model (STDSIM), we made projections of HIV spread for four profiles of sexual behaviour reflecting patterns encountered across the developing world: 1) much commercial sex, no short relationships; 2) commercial sex, concurrent short relationships; 3) concurrent relation...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:Bringing together various disease-specific guidelines for sick children, WHO and UNICEF have developed an Integrated Management of Childhood Illness (IMCI) algorithm, one component of which (assess and classify) was tested in the outpatient department of a rural district hospital in western Uganda. Children aged 2-59 ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:This paper is a report on an attempt to study seasonal variations in endemic cholera in West Bengal by statistical analysis of monthly mortality records over a 21-year period. The annual death-rates have been calculated for each month in each district and the average of the seven lowest rates in each district is plott...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1961-01-01 00:00:00
abstract：:Enzyme-linked immunosorbent asays (ELISAs) are described for determining levels of dapsone and pyrimethamine in urine. Both assays have a sensitivity of about 20 mug/l and are reproducible, but each produces some false positives. The problem of false positive reactions was partially obviated by requiring positive resu...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:In a continuing search for more effective molluscicides, tests were carried out in the Egypt-49 area on Molucid and WL 8008. Molucid, a 35% w/v solution of isobutyltriphenyl-methylamine (ICI 24223), was applied at 2 ppm for 6 hours; after the treatment, no live Bulinus truncatus, Biomphalaria alexandrina or Lymnaea ca...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1966-01-01 00:00:00
abstract：:The effects of measles immunization on diarrhea morbidity and mortality are reviewed using data from field studies and theoretical calculations. 2 types of measles-associated diarrhea are distinguished: with-measles diarrhea, which starts between 1 week prerash-onset and 4 weeks postrash-onset, and postmeasles diarr...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：Objective:To assess the outcomes of children diagnosed with hearing impairment 3 years earlier in terms of referral uptake, treatment received and satisfaction with this treatment, and social participation. Methods:We conducted a population-based longitudinal analysis of children with a hearing impairment in two rural...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.18.226241
更新日期：2019-10-01 00:00:00
abstract：:This paper synthesizes the rates, barriers, and outcomes of HIV serostatus disclosure among women in developing countries. We identified 17 studies from peer-reviewed journals and international conference abstracts--15 from sub-Saharan Africa and 2 from south-east Asia--that included information on either the rates, b...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,评审
doi：
更新日期：2004-04-01 00:00:00
abstract：:This report presents the results of serological analyses made by the laboratory of the Treponematoses Control Project, Indonesia, from its establishment in April 1951 until April 1953. All sera were tested quantitatively with the VDRL and Kline slide-tests or the Kahn test, or with all three.A study of the mean reagin...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1955-01-01 00:00:00
abstract：OBJECTIVE:To estimate post-traumatic stress disorder (PTSD) symptoms in those injured and not injured by landmines or unexploded ordnance (UXO) in rural Lao People's Democratic Republic and to determine whether the perception of social support was associated with PTSD symptom severity. METHODS:A community survey was c...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.12.115311
更新日期：2013-10-01 00:00:00
abstract：:Doubts have been raised on theoretical grounds concerning the effect of BCG in tropical countries, where in most places a large proportion of the population have a naturally acquired tuberculin allergy of low strength and unknown (but almost certainly non-specific) origin. Furthermore, vaccinations in the tropics may ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1964-01-01 00:00:00
abstract：OBJECTIVE:To assess the effectiveness of treatment for hepatitis C virus (HCV) infection in low- and middle-income countries and identify factors associated with successful outcomes. METHODS:We performed a systematic review and meta-analysis of studies of HCV treatment programmes in low- and middle-income countries. T...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,meta分析,评审
doi：10.2471/BLT.11.097147
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVE:To describe the adaptation and scaling-up of an intervention to improve the visual health of children in the Apurimac region, Peru. METHODS:In a pilot screening programme in 2009-2010, 26 schoolteachers were trained to detect and refer visual acuity problems in schoolchildren in one district in Apurimac. To ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.15.163634
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE:To determine whether vaccination against measles in a population with sustained high vaccination coverage and relatively low child mortality reduces overall child mortality. METHODS:In April and May 2000, a population-based, case-control study was conducted at Ballabgarh (an area in rural northern India). El...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Village-wide use of permethrin-impregnated bed nets, compared with placebo-treated nets, has reduced clinical attacks of malaria by 63% in the Gambia. Costs were calculated for nets made by local tailors and for their treatment with insecticide in the villages, as well as for targeted chemoprophylaxis and back-up trea...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Although none of the currently available methods of contraception can be considered ideal for use by adolescents, many come reasonably close. The present article reviews the relative benefits and risks associated with each method. Oral contraceptives (OCs) appear to bear few specific risks for adolescents. Pills co...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
