Abstract：
:A case-control study was conducted in Yaoundé, United Republic of Cameroon, to evaluate the hypothesis that intramuscular inoculations predisposed young children to paralysis if they were later exposed to poliomyelitis virus. Thirty-three cases with lower motor neuron disease and 66 neighbourhood controls were studied. Poliovirus was isolated from 39% of the paralytic cases but from only 18% of the comparison group. Controls were more likely to have had serological evidence of previous exposure to all three poliovirus types while most of the paralytic cases had been exposed to a poliovirus for the first time. Two-thirds of the paralytic cases but only 11% of the comparison group had been ill, visited a medical facility, and received multiple injections, primarily with quinine and penicillin, in the month prior to the onset of poliomyelitis. There was a strong temporal relationship between these injections and the onset of paralysis. The increased relative risks (15 and 32, respectively) of paralysis associated with inoculations in the two weeks immediately prior to onset of disease were felt to represent the treatment of symptoms related to poliomyelitis. However, the increased relative risks (13 and 27, respectively) three and four weeks prior to onset were felt to be consistent with the hypothesis that intramuscular injections provoked paralysis. Overestimation of this measure of the effect because of bias in the control group is discussed.
journal_name
Bull World Health Organjournal_title
Bulletin of the World Health Organizationauthors
Guyer B,Bisong AA,Gould J,Brigaud M,Aymard Msubject
Has Abstractpub_date
1980-01-01 00:00:00pages
285-91issue
2eissn
0042-9686issn
1564-0604journal_volume
58pub_type
杂志文章abstract：:Vaccination of pre-school children in the 1-7-years age-group for the specific prophylaxis of mumps and rubella is often difficult to arrange because of the already large number of inoculations given to these children. Combined vaccines to protect against measles, mumps and rubella should therefore be a valuable devel...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1970-01-01 00:00:00
abstract：:DDE and the o,p' and p,p' isomers of DDT were assayed in 94 human biopsy fat samples from hospitals in Delhi by gas chromatography. DDT was present in all except 2 samples at concentrations from 0.17 to 176.5 mg per kg of body fat. The average total DDT content was 21.8+/-2.9 mg/kg, of which 45.9% was DDE. The average...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:Several authors have reported an inverse correlation between death rates from cardiovascular diseases and local water hardness, but the significance of such a relationship is still debated. To investigate further this relationship, another indicator of water quality was used, namely, the alpha-radioactivity level of r...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1970-01-01 00:00:00
abstract：:The intrinsic qualities of influenza virus particles may be studied at the biological level from two points of view:(1) The surface structures associated with adsorption to the surface of the susceptible cell and entry into its substance are regarded as essentially somatic in character. Infection is possible only when...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1953-01-01 00:00:00
abstract：:The efficacy of standard potency Edmonston-Zagreb (E-Z) measles vaccine was tested in a randomized trial of Black infants in a rural area of South Africa where a measles epidemic was occurring. The following immunization schedules were used: 48 infants aged 4-8.5 months who received 3.9 log 50 infectious units of E-Z ...
journal_title：Bulletin of the World Health Organization
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1991-01-01 00:00:00
abstract：:This article provides a framework for the design of future eradication programmes so that the greatest benefit accrues to health systems development from the implementation of such programmes. The framework focuses on weak and fragile health systems and assumes that eradication leads to the cessation of the interventi...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：Objective:To estimate the level and trend of development assistance for community health worker-related projects in low- and middle-income countries between 2007 and 2017. Methods:We extracted data from the Organisation for Economic Co-operation and Development's creditor reporting system on aid funding for projects t...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.19.235499
更新日期：2020-01-01 00:00:00
abstract：:Forecasts of tuberculosis morbidity and mortality are presented for the decade 1990-99. An estimated 88 million new cases of tuberculosis, of which 8 million will be attributable to HIV infection, will occur in the world during the decade; 30 million people are predicted to die of tuberculosis in the same period, incl...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:The presence of non-specific inhibitors in immune influenza sera may falsify the antibody pattern as shown by the haemagglutination-inhibition test, and it is consequently often necessary to pre-treat sera in order to inactivate these inhibitors. A number of different methods are in use for this purpose. It was theref...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1960-01-01 00:00:00
abstract：OBJECTIVE:To determine the leading causes of fatal injury for urban South African children aged 0-14 years, the distribution of those causes and the current potential for safety improvements. METHODS:We obtained injury surveillance data from the National Injury Mortality Surveillance System 2001-2003 for six major Sou...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.09.068486
更新日期：2010-04-01 00:00:00
abstract：:Selective population chemotherapy using a single dose of praziquantel (40 mg per kg body weight), which was offered to 29,365 schoolchildren in Abu El Matameer and 40,241 in Abo Homos districts, Beheira governorate in the Nile delta, reduced the prevalence of schistosomiasis from 75.4% to 40.9% (reduction of 45.8%) an...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:There is a need for more detailed information on the relative merits of the culture and direct sputum smear examination methods, separately and in various combinations, using one or more sputum specimens. The efficiency and relative cost of different bacteriological measures for the detection of cases of pulmonary tub...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1971-01-01 00:00:00
abstract：:A study was undertaken in Bangalore City, India, to find out whether people with chest symptoms, including tuberculosis patients, attend general health institutions or report directly to tuberculosis clinics. The attendance for one day at 19 general dispensaries was investigated. Of the total of 2506 eligible persons ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1970-01-01 00:00:00
abstract：:Three diphtheria toxoid preparations, fractionated at various concentrations of ammonium sulfate, having various grades of purity, and showing striking differences in immunizing potency when compared at the same Lf dose, were examined for similarity of the effective constituents in the fractions. No evidence of deviat...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1954-01-01 00:00:00
abstract：:The use of BCG vaccine in the prevention of leprosy has been one of the most important subjects of investigation in the field of leprology in the last 25 years. The action of the vaccine was for many years investigated by determining its effect on the lepromin reaction. Field studies were later considered essential to...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1970-01-01 00:00:00
abstract：:The systematic position of the so-called "species" of Leishmania is examined and an attempt made to determine their phylogenetic relationships. The morphology of the organisms as seen by light- and electron-microscopy is described; neither method provides useful criteria for the determination of species. The behaviour...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1971-01-01 00:00:00
abstract：:The efficacy of BCG vaccine in preventing the clinical manifestations of leprosy in a tuberculosis-free area of Papua New Guinea is reported. Between 1963 and 1966 a total of 5356 subjects, randomized to receive BCG or saline inoculations, were examined for leprosy before the vaccination and surveillance was continued...
journal_title：Bulletin of the World Health Organization
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1989-01-01 00:00:00
abstract：:Indirect immunofluorescence (IF) was used to localize stage-specific antigen(s) on the surface of the sporozoite membrane. The authors examined the feasibility of using an IF assay to determine whether an antisporozoite response is developed by individuals living in endemic areas. The specificity and sensitivity of th...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:In the course of WHO/UNICEF-assisted tuberculosis surveys carried out in a number of African territories, sputa were microscopically examined for the presence of acid-fast bacilli. Since adequate facilities for performing cultures to confirm the diagnosis of tuberculosis and other mycobacterial infections were not ava...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1960-01-01 00:00:00
abstract：:The availability of affordable medicines is a major barrier to providing high-quality health care in many countries. Fatima Suleman talks to Fiona Fleck. ...
journal_title：Bulletin of the World Health Organization
pub_type： 传,历史文章,新闻
doi：10.2471/BLT.17.031217
更新日期：2017-12-01 00:00:00
abstract：:Cardiovascular diseases are often found to be associated with certain physicochemical characteristics of the environment-namely, the hardness of the water and the types of rock and soil underlying the area. Areas supplied with soft water usually have higher cardiovascular death rates than do areas supplied with hard w...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1972-01-01 00:00:00
abstract：:Several thousand Glossina pallidipes flies were dissected to determine trypanosome infection rates in the Lambwe Valley and to collect information on the hosts of this tsetse. A total of 1 450 (19.3%) flies had mature trypanosome infections but the rate varied between 9.6% and 30.9% in the Lambwe Valley. In the Roo Va...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1972-01-01 00:00:00
abstract：:Early identification of children at high risk of diarrhoea-associated dehydration would be of great value to health care workers in developing countries. To identify prognostic factors for life-threatening dehydration, we carried out a case-control study among under-2-year-olds in Porto Alegre, Brazil. Cases were 192 ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:This month the World Health Assembly discusses the post-2015 global tuberculosis strategy and accompanying set of targets. Giovanni Battista Migliori tells Fiona Fleck how his institute - one of WHO's thousands of partners across the globe - can contribute in future to its implementation, once it is approved. ...
journal_title：Bulletin of the World Health Organization
pub_type： 面试,新闻
doi：10.2471/BLT.14.030514
更新日期：2014-05-01 00:00:00
abstract：:Vaccines constitute the single most important cost factor in the Expanded Programme on Immunization (EPI) in Mozambique and in view of future new disease-control initiatives, the proportional expenditure on vaccines will only increase. Airfreight may contribute up to at least 25% of the total cost of delivered vaccine...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Adult male volunteers were orally vaccinated with two "killed" antityphoid preparations. The recommended doses of both vaccines resulted in serum antibody development in only a few of the subjects. When the dose of the monovalent preparation (Taboral) was doubled, serological responses occurred more frequently, with a...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1971-01-01 00:00:00
abstract：:This paper presents estimates of the prevalence of visual impairment and its causes in 2002, based on the best available evidence derived from recent studies. Estimates were determined from data on low vision and blindness as defined in the International statistical classification of diseases, injuries and causes of d...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：/S0042-96862004001100009
更新日期：2004-11-01 00:00:00
abstract：:In the early summer of 1993, an outbreak of Rift Valley fever (RVF) was reported among both humans and animals in Aswan Governorate, Upper Egypt. To determine whether RVF infection had spread to the Nile delta region of the country, we carried out a cross-sectional survey of 1181 occupationally exposed abattoir worker...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Histochemical staining methods for acid phosphatase were used to study the differences among microfilariae of various West African strains of Onchocerca volvulus in both forest and Sudan-savanna onchocerciasis zones. The results have shown statistically significant differences in the staining patterns of microfilarial...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:Bringing together various disease-specific guidelines for sick children, WHO and UNICEF have developed an Integrated Management of Childhood Illness (IMCI) algorithm, one component of which (assess and classify) was tested in the outpatient department of a rural district hospital in western Uganda. Children aged 2-59 ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
