Abstract：
:Simultaneously with the development of vaccines against diphtheria, the authors and their colleagues have studied the biological properties of the causative agent, Corynebacterium diphtheriae, and its role in the development of epidemics. This study has been made possible by the development of a lysotyping scheme for the bacterium, covering all three biotypes-gravis, intermedius and mitis. On the basis of this scheme it was possible to lysotype 73% of the 8694 strains of C. diphtheriae isolated in Romania between 1956 and 1966-99% of the gravis strains, 39% of the intermedius and 19% of the mitis; in all, 19 lysotypes were distinguished.To check the applicability of the lysotyping scheme on an international scale, 395 strains of C. diphtheriae were obtained from the reference laboratories in 14 countries in four continents. It was possible to lysotype 62% of the strains, including 93% of the gravis type. Details are given of the geographical distribution of the different lysotypes; two lysotypes not isolated in Romania were encountered among the foreign strains and will be incorporated into the scheme as the 20th and 21st lysotypes.There is a need to extend the number of intermedius- and mitis-type phages to enable more of these types of strain to be distinguished.
journal_name
Bull World Health Organjournal_title
Bulletin of the World Health Organizationauthors
Saragea A,Maximescu Psubject
Has Abstractpub_date
1966-01-01 00:00:00pages
681-9issue
5eissn
0042-9686issn
1564-0604journal_volume
35pub_type
杂志文章abstract：OBJECTIVES:To implement and evaluate a public-private partnership to deliver the internationally recommended strategy DOTS for the control of tuberculosis (TB) in Lalitpur municipality, Nepal, where it is estimated that 50% of patients with TB are managed in the private sector. METHODS:A local working group developed ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：2004-02-01 00:00:00
abstract：:This article surveys the attitudes and perceptions of a random sample of the elderly population in three regions of Italy on the use and efficacy of influenza vaccine. The data were collected by direct interviews using a standard questionnaire. The results show that vaccination coverage against influenza is inadequate...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Recent studies with the indirect haemagglutination test for malaria are reviewed. Aspects of methodology, reproducibility, specificity, and sensitivity are discussed. A procedure is presented for application in the field, which indicates some progress towards developing a simple field method for the epidemiological su...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1974-01-01 00:00:00
abstract：OBJECTIVE:To document the inclusion of key medicines for children in national essential medicines lists (EMLs) and standard treatment guidelines, and to assess the availability and cost of these medicines in 14 countries in central Africa. METHODS:Surveys were conducted in 12 public and private sector medicine outlets...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/blt.08.053645
更新日期：2009-03-01 00:00:00
abstract：:This chapter presents the findings arrived at by applying the resource allocation model to tuberculosis control in the Republic of Korea. Optimum subprogrammes are obtained for the four objectives of the programme: reduction of disability, impairment, excess mortality, and economic loss. These subprogrammes are discus...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:In order to study the role of genetic factors in susceptibility to leprosy infection, the prevalence of leprosy in 118 pairs of Burmese villages different distances apart was investigated. The distribution pattern of the correlation coefficients for leprosy rates was compared with that known to occur for genetic marke...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:Until about 10 years ago heparin was prepared from ox lungs and was regarded as a homogeneous polymer (of a sulfated mucopolysaccharide) with a relatively constant biological activity of about 100 IU/mg. The mucus and mucosa of the intestine of hog, sheep and ox have now become the main industrial source of bulk start...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1970-01-01 00:00:00
abstract：:Signs in the fundus oculi, long regarded as prognostic in hypertensive disease, have been shown to be subject to gross observer error and bias when assessed in conventional ways. The authors describe unconventional ways of assessing diminution of vascularity in a population sample of men aged 50 and also in a group of...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1967-01-01 00:00:00
abstract：:In 1954-55, a controlled field trial of two types of typhoid vaccine-alcoholized ("vaccine A") and phenolized ("vaccine F")-prepared in Yugoslavia was carried out in the town and district of Osijek. In an attempt to correlate the protection conferred on man by these vaccines with their potency in laboratory animals, a...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1959-01-01 00:00:00
abstract：:Public and political awareness of emerging infectious diseases is growing, as animal and human health specialists work closer together to avert potential outbreaks. ...
journal_title：Bulletin of the World Health Organization
pub_type： 新闻
doi：10.2471/BLT.11.031211
更新日期：2011-12-01 00:00:00
abstract：:Immunization of non-pregnant women in rural Bangladesh with two doses of aluminium-adsorbed tetanus-diphtheria toxoids reduced neonatal mortality by one-third during a period of 9-32 months after vaccination. The reduction in mortality rate was attributable almost entirely to a 75% lower mortality rate among 4-14-day-...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Vaccination of pre-school children in the 1-7-years age-group for the specific prophylaxis of mumps and rubella is often difficult to arrange because of the already large number of inoculations given to these children. Combined vaccines to protect against measles, mumps and rubella should therefore be a valuable devel...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1970-01-01 00:00:00
abstract：:Based on studies carried out by the author and his associates in areas of Japan and South Asia where malayan and bancroftian filariasis is endemic, this paper recommends methods for use in microfilaria surveys and in the analysis of data obtained in such surveys. The author recommends the use of measured blood samples...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1967-01-01 00:00:00
abstract：:A survey of bilharziasis and its vectors in certain countries of north-east Africa and of the Red Sea area, carried out between December 1951 and February 1952, is described within the framework of a review of the somewhat scattered and incomplete information already available on this subject in the literature. Clinic...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1956-01-01 00:00:00
abstract：:Present methods of controlling meningococcal cerebrospinal meningitis have failed to contain the disease. This has led to the search for effective vaccines and to the development of methods for assaying the potency of these vaccines, as well as for measuring the immune response of the individual. The feasibility of us...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1969-01-01 00:00:00
abstract：:It remains unclear why there is such marked variation in the severity of the human immunodeficiency virus (HIV) epidemic between African countries. The prevalence of HIV infection has reached high levels in many parts of southern Africa but in most countries of West Africa the levels are much lower. Although there is ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,评审
doi：
更新日期：2001-01-01 00:00:00
abstract：:Histochemical staining methods for acid phosphatase were used to study the differences among microfilariae of various West African strains of Onchocerca volvulus in both forest and Sudan-savanna onchocerciasis zones. The results have shown statistically significant differences in the staining patterns of microfilarial...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:In Iran, microscopic examination of skin scrapings from 2202 individuals with clinically diagnosed cutaneous leishmaniasis (CL) lesions revealed the presence of amastigotes in 1123 cases (51.0%). Bacteriological examinations of the lesions indicated that 788 individuals (35.7%) were also infected with one or more path...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:There was a dramatic rise in the prevalence of urinary schistosomiasis around Volta Lake within a year of its full impoundment in 1968. Research was undertaken to investigate the epidemiology of the disease in preparation for a control programme. The interplay of three factors-age, sex, and ethnic affiliation-largely ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:The precautions to be taken and the procedures to be followed when giving intramuscular injections are well known, but they are not always satisfactorily observed under conditions such as those met with in mass treatment campaigns against the treponematoses, nor is the importance of employing uniform techniques always...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1958-01-01 00:00:00
abstract：:An influenzavirus of swine origin (swine/Taiwan/7310/70) antigenically closely related to the human A/Hong Kong/68 virus readily infected human volunteers. Those infected developed antihaemagglutinin and antineuraminidase antibodies to the human A/Hong Kong/68 virus as well as to the swine/Taiwan virus. The clinical r...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1972-01-01 00:00:00
abstract：:This paper generates and analyses survey data on inequalities in mortality among infants and children aged under five years by consumption in Brazil, Côte d'Ivoire, Ghana, Nepal, Nicaragua, Pakistan, the Philippines, South Africa, and Viet Nam. The data were obtained from the Living Standards Measurement Study and the...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
abstract：:Thiomersal-iodine-formalin (TIF) has been used as a faecal preservative in many prevalence surveys of intestinal helminths and protozoa. In helminth surveys, however, estimates of worm burden are no less essential than those of prevalence. Direct-smear and dilution egg-counting techniques, using fresh faeces, have bee...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1968-01-01 00:00:00
abstract：:Recent research carried out on kwashiorkor in Kampala, Uganda, is discussed. The first essential in both the treatment and the prevention of this disease being a diet rich in protein (preferably animal protein, to ensure an adequate intake of vitamin B(12) and a satisfactory mixture of amino-acids), methods of incorpo...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1953-01-01 00:00:00
abstract：:Access to contraceptives in Africa has not increased at the same pace as elsewhere in the world. Some African nations are investing in family planning services to reduce fertility rates, improve economic development and their population's health. Tatum Anderson reports. ...
journal_title：Bulletin of the World Health Organization
pub_type： 新闻
doi：10.2471/BLT.17.020917
更新日期：2017-09-01 00:00:00
abstract：:The One Health concept covers the interrelationship between human, animal and environmental health and requires multistakeholder collaboration across many cultural, disciplinary, institutional and sectoral boundaries. Yet, the implementation of the One Health approach appears hampered by shortcomings in the global fra...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.17.202705
更新日期：2018-03-01 00:00:00
abstract：PROBLEM:The visit of Pope Francis to the Philippines in January 2015 coincided with a tropical storm. For security reasons, the only road in and out of the area was closed 14.5 hours before the Pope's arrival. This meant that people had to wait for many hours with little shelter at the site. Medical teams in the field ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.15.158089
更新日期：2015-11-01 00:00:00
abstract：:The patent system is now reaching into the tools of medical research, including gene sequences themselves. Many of the new patents can potentially preempt large areas of medical research and lay down legal barriers to the development of a broad category of products. Researchers must therefore consider redesigning thei...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:The large epidemic of bovine spongiform encephalopathy (BSE) in the United Kingdom has been in decline since 1992, but has spread to other countries. The extensive control measures that have been put in place across the European Union and also in Switzerland should have brought the transmission of BSE under control in...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
abstract：:To provide the basic information needed for studies of drug toxicity in rats suffering from protein deficiency, weanling male albino rats were fed for 28 days on either laboratory chow or a synthetic diet containing 27% or 8% of casein. The low-protein diet produced a kwashiorkoric cachexia characterized by stunting, ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1968-01-01 00:00:00
