Abstract：
:In 1954-55, a controlled field trial of two types of typhoid vaccine-alcoholized ("vaccine A") and phenolized ("vaccine F")-prepared in Yugoslavia was carried out in the town and district of Osijek. In an attempt to correlate the protection conferred on man by these vaccines with their potency in laboratory animals, arrangements were made for laboratory tests to be performed jointly by the Central Institute of Hygiene, Zagreb, Yugoslavia; the Lister Institute of Preventive Medicine, Elstree, Herts, England; and the Walter Reed Army Institute of Research (WRAIR), Washington, D.C., USA. In this paper, the results of the WRAIR tests are presented.The potency relationship between vaccine A and vaccine F was found to vary with the type of test performed. According to active-immunization tests in mice, using either mucin or saline challenge, vaccine A was more potent than vaccine F, as it proved also in the passive immunization of mice with saline challenge and in Vi-antibody production in rabbits. As judged by the results of the passive immunization of mice with mucin challenge and of O-antibody production in rabbits, there was, however, no clear-cut difference in potency between the two vaccines. And, as indicated by H-antibody production in rabbits, vaccine F was clearly superior to vaccine A. Since vaccine F was also the more effective in man, the last-mentioned findings are of considerable interest, suggesting that the H antigen may be more, and the Vi antigen less, important in protecting man against typhoid fever than is currently considered to be the case.
journal_name
Bull World Health Organjournal_title
Bulletin of the World Health Organizationauthors
EDSALL G,CARLSON MC,FORMAL SB,BENENSON ASsubject
Has Abstractpub_date
1959-01-01 00:00:00pages
1017-32eissn
0042-9686issn
1564-0604journal_volume
20pub_type
杂志文章abstract：OBJECTIVE:To assess the effectiveness of treatment for hepatitis C virus (HCV) infection in low- and middle-income countries and identify factors associated with successful outcomes. METHODS:We performed a systematic review and meta-analysis of studies of HCV treatment programmes in low- and middle-income countries. T...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,meta分析,评审
doi：10.2471/BLT.11.097147
更新日期：2012-07-01 00:00:00
abstract：:Since the development of insecticide-resistance and the consequent partial failure of the chemical approach to the control of disease vectors, interest in the biological approach has re-awakened. An aspect of the latter approach that is of great current interest is "autocidal control"-that is, the use of insects for t...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1963-01-01 00:00:00
abstract：:Since the first attempt at vaccination more than 200 years ago, debate has been ongoing about the relative benefits and risks. However, debate was overshadowed by the threat of crippling illness and death. Over the years, vaccination programs succeeded in its goals: eradication of smallpox, near eradication of polio,...
journal_title：Bulletin of the World Health Organization
pub_type： 评论,杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:Hepatic damage caused by chronic exposure to arsenic has been frequently described. Here we report on 13 patients from West Bengal, India, who consumed large amounts of arsenic in drinking water. An epidemiological investigation of the study area showed evidence of chronic arsenical dermatosis and hepatomegaly in 62 (...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:A study spanning 10 years indicates that the erythrocytic stages of malarial parasites can be stored indefinitely in the vapour phase of liquid nitrogen without significant loss of infectivity. The results also suggest that loss due to the recovery procedures exceeds any loss that may have occurred during freezing and...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:A taxonomic approach using cluster analysis and principal component analysis has grouped the countries of the world in eight clusters, in an initial attempt to propose a worldwide spatial classification based on the following health-related indicators: (a) those directly related to the health status of the population;...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Potency determinations in mice of venom samples from snakes of the species Bothrops jararaca, which had been caught in an area of less than 10 000 km(2), gave the following principal results:(1) Various methods of drying-i.e., closed and continuous vacuum-drying at 5 degrees and 37 degrees C and freeze-drying (lyophil...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1958-01-01 00:00:00
abstract：:In the fight against the HIV/AIDS pandemic different approaches can be distinguished, reflecting professional backgrounds, world views and political interests. One important distinction is between the biomedical and the development paradigms. The biomedical paradigm is characterized by individualization and the concep...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
abstract：:The single radial haemolysis reaction has been shown to be suitable for the quantitative assay of specific antibody to West Nile and Sindbis viruses. Only 5 mul of undiluted serum are needed for the test, which can be performed on crude preparations of antigen and without removal of nonspecific inhibitors. It is there...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:Many global health institutions, including the World Health Organization, consider primary health care as the path towards achieving universal health coverage (UHC). However, there remain concerns about the feasibility and effectiveness of this approach in low-resource countries. Ethiopia has been implementing the pri...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.19.248328
更新日期：2020-12-01 00:00:00
abstract：:This month the World Health Assembly discusses the post-2015 global tuberculosis strategy and accompanying set of targets. Giovanni Battista Migliori tells Fiona Fleck how his institute - one of WHO's thousands of partners across the globe - can contribute in future to its implementation, once it is approved. ...
journal_title：Bulletin of the World Health Organization
pub_type： 面试,新闻
doi：10.2471/BLT.14.030514
更新日期：2014-05-01 00:00:00
abstract：:Thiomersal-iodine-formalin (TIF) has been used as a faecal preservative in many prevalence surveys of intestinal helminths and protozoa. In helminth surveys, however, estimates of worm burden are no less essential than those of prevalence. Direct-smear and dilution egg-counting techniques, using fresh faeces, have bee...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1968-01-01 00:00:00
abstract：:Until about 10 years ago heparin was prepared from ox lungs and was regarded as a homogeneous polymer (of a sulfated mucopolysaccharide) with a relatively constant biological activity of about 100 IU/mg. The mucus and mucosa of the intestine of hog, sheep and ox have now become the main industrial source of bulk start...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1970-01-01 00:00:00
abstract：:The isolation of West Nile virus from the brain tissue of three children who died of encephalitis in Mysore and Kolar districts of Karnataka State, India, is reported. This is the first such report from India. The significance of these isolations with reference to the role of West Nile virus in encephalitis in childre...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:The reaction that occurs on direct radioelectrocomplexing (REC) between hepatitis B antibody (HB Ab) and (125)I-labelled HB Ag can be inhibited by unlabelled HB Ag. Inhibition of REC provides a rapid, sensitive method for the detection of HB Ag. ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：OBJECTIVE:To perform a comprehensive assessment of maternal mortality in Argentina, the ultimate purpose being to strengthen the surveillance system and reorient reproductive health policies to prevent maternal deaths. METHODS:Our multicentre population-based study combining qualitative and quantitative methodologies ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,多中心研究
doi：10.2471/blt.06.032334
更新日期：2007-08-01 00:00:00
abstract：:Since the appearance of DDT-resistance in houseflies in 1947, over 30 mosquito species have developed resistance to this and other commonly used insecticides. Much knowledge has been gained concerning the mechanism of resistance in insects but, in general, this phenomenon cannot be explained in terms of a single facto...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1967-01-01 00:00:00
abstract：Objective:To assess cash transfer interventions for improving treatment outcomes of active pulmonary tuberculosis in low- and middle-income countries. Methods:We searched PubMed®, Embase®, Cochrane Library and ClinicalTrials.gov for studies published until 4 August 2017 that reported on cash transfer interventions dur...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,meta分析,评审
doi：10.2471/BLT.18.208959
更新日期：2018-07-01 00:00:00
abstract：:In order to contribute to knowledge of the sporogonic cycle of malaria parasites, 3 batches of Anopheles labranchiae atroparvus were infected with the VS Romanian strain of Plasmodium malariae by feeding them on 2 patients undergoing malariotherapy in Romania. Of the 310 infected mosquitos 59 were dissected for ookine...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1968-01-01 00:00:00
abstract：:Yellow fever was responsible for several epidemics among the settlers in tropical areas of the Americas and Africa during the 17th to the 19th centuries. Scientific research into its cause and epidemiology was started at the beginning of the present century and progressed well ahead of other viral disease research. Ho...
journal_title：Bulletin of the World Health Organization
pub_type： 历史文章,杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVE:To explore excess paediatric mortality after discharge from Kilifi District Hospital, Kenya, and its duration and risk factors. METHODS:Hospital and demographic data were used to describe post-discharge mortality and survival probability in children aged < 15 years, by age group and clinical syndrome. Cox re...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.11.089235
更新日期：2011-10-01 00:00:00
abstract：:In Papua New Guinea the bottle-feeding of babies has been increasing, predominantly among unemployed women of low educational status. Many women are unaware of their legal right to have breaks at work for the purpose of breastfeeding, and a high proportion of workplaces have no facilities for mothers who wish to breas...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Inherited resistance to anticoagulant rodenticides was discovered in populations of Rattus norvegicus about 14 years ago. Similar resistance has now been reported from several countries in north-western Europe and from the USA. In order to detect resistance and to control it effectively, basic data on the susceptibili...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1972-01-01 00:00:00
abstract：:The insecticidal activity of synthetic pyrethroids was compared with that of the natural pyrethrins, which have been used on a world-wide scale as active ingredients for insecticidal aerosols or mosquito coils.All of the synthetic pyrethroids were found to be more stable than the pyrethrins. Tetramethrin showed a very...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1971-01-01 00:00:00
abstract：:In a controlled study, it has been shown that the prior administration of cholera vaccine had no beneficial effect on the clinical course of cholera as measured by either the condition of the patient on admission to hospital or the subsequent course of the disease. In fact, the disease was, if anything, more severe in...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1969-01-01 00:00:00
abstract：:This report presents the results of serological analyses made by the laboratory of the Treponematoses Control Project, Indonesia, from its establishment in April 1951 until April 1953. All sera were tested quantitatively with the VDRL and Kline slide-tests or the Kahn test, or with all three.A study of the mean reagin...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1955-01-01 00:00:00
abstract：:The respective vectors of the two forms of bilharziasis in Egypt do not have the same ecological distribution. Bulinus truncatus is most abundant in large canals, and decreases in density as the water approaches and flows into drains. Biomphalaria alexandrina is most abundant in drains, and decreases in density upstre...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1966-01-01 00:00:00
abstract：:The acute toxicity of most of the commonly used organophosphorus insecticides is essentially the same. A few compounds with low toxicity, such as malathion, have been developed but further efforts in that direction are needed. Most of the organophosphorus insecticides exert a generalized cholinergic action by inhibiti...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1971-01-01 00:00:00
abstract：:WHO's reference protocol for post-exposure rabies vaccination advises five intramuscular injections on days 0, 3, 7, 14, and 30; in addition, rabies immunoglobulins (RIG) must be given to serious cases of exposure (grade III severity). Some studies indicate that these immunoglobulins suppress the immunogenicity of rab...
journal_title：Bulletin of the World Health Organization
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1998-01-01 00:00:00
abstract：:The effects of measles immunization on diarrhea morbidity and mortality are reviewed using data from field studies and theoretical calculations. 2 types of measles-associated diarrhea are distinguished: with-measles diarrhea, which starts between 1 week prerash-onset and 4 weeks postrash-onset, and postmeasles diarr...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
