当前位置： SCI文献检索 > JOURNAL OF CLINICAL GASTROENTEROLOGY期刊下所有文献 > Epidemiology of Crohn's Disease.

Epidemiology of Crohn's Disease.

Abstract：

:Although our current understanding is limited, epidemiologic investigation of Crohn's disease holds great promise. Certain aspects of the epidemiology are clear. The incidence of Crohn's disease, which has increased over the past few decades, may have reached a plateau. The disease has its peak onset in early life, with a second peak among the elderly. It is more common in the developed countries and among Jews. Whether the disease is related to occupation, social class, marital status, stress, infection, diet, smoking, and oral contraceptives is less certain. This paper reviews the epidemiology of Crohn's disease and proposes areas in which further research is needed. :Some of what is known about the epidemiology of Crohn's disease (CD) is reviewed in an effort to propose areas in which further research is needed. The discussion covers incidence, race and sex, age, urban/rural residence, religion, diet, familial pattern, infection, marital status, occupation and social class, the use of oral contraceptives (OCs), smoking, and a number of miscellaneous factors. The increase in incidence of the disease appears to have reached a plateau, and now ranges from 1.3 to 5.3/100,000 population. Possible causes for the plateau include no recent breakthroughs in the diagnosis of CD and the fact that physicians now are generally aware of the disease. An alternate explanation is that the etiologic agent responsible for CD has become less common. Crohn's disease is most common in the developed countries of Europe, Scandinavia, and the US and generally is thought to be more common in whites. Yet, in the most recent data from Baltimore, the age adjusted rates for white men were about those for nonwhite men, whereas the rates for nonwhite women were higher than white women. There are no significant differences in the clinical features of the disease between whites and nonwhites. The ratio of males to females with CD is approximately 1, which provides little insight into the cause of the disease. The equal sex ratio does speak against a marked occupational or hormonal influence on the disease. Crohn's disease has its greatest onset in the adolescent and young adult years, between 15-25. A number of studies have discovered a 2nd peak in incidence between ages 50-80. CD is generally acknowledged to be more common in urban populations, but the literature is conflicting on this point. Most studies have found an excess of CD among Jews. Rozen et al. found the disease was uncommon in Israeli-born or non-Ashkenazi Jews. Investigation of the association between dietary factors and CD has not proven helpful. Patients with CD have more relatives with either CD or ulcerative colitis than one would expect at random. An infectious agent for CD continues to be sought in the laboratory without success. Some studies have found the disease more common in single persons. Data on occupation and socioeconomic status are conflicting. A recent study from Great Britain found that a significant excess of women with CD confined to the colon had taken OCs in the year before developing symptoms compared to women with small bowel CD and ulcerative colitis. Several recent studies have found that patients with CD are more likely to be smokers. Patients with CD have been found to have more schooling than control groups in Baltimore, and patients with CD have been found to have an increased incidence of gastroenteritis during the first 6 months of life.

journal_name

J Clin Gastroenterol

journal_title

Journal of clinical gastroenterology

authors

Sandler RS,Golden AL

doi

10.1097/00004836-198604000-00011

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

160-5

issue

eissn

0192-0790

issn

1539-2031

journal_volume

pub_type

杂志文章

在线工具

Epidemiology of Crohn's Disease.