当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > Endothelial cell recovery between comparator polymer-based drug-eluting stents.

Endothelial cell recovery between comparator polymer-based drug-eluting stents.

Abstract：

OBJECTIVES:The purpose of this study was to assess trends in endothelial coverage and recovery among leading polymer-based drug-eluting stents (DES). BACKGROUND:Autopsy studies of human U.S. Food and Drug Administration (FDA)-approved DES implanted coronary arteries suggest that complications of late stent thrombosis are associated with incomplete endothelial coverage of struts. METHODS:Rabbits received sirolimus-eluting stents (SES), paclitaxel-eluting stents (PES), zotarolimus-eluting stents (ZES), and everolimus-eluting stents (EES) for 14 or 28 days along with MULTI-LINK (ML) Vision control stents. Endothelial coverage above and between struts was measured by morphometric analysis of images acquired through en face scanning electron microscopy. Dual fluorescent immunolabeling was performed for platelet-endothelial cell adhesion molecule (PECAM)-1 and thrombomodulin (TM), factors involved in cell-to-cell contact and thrombogenicity, respectively. In a separate analysis, the endothelial mitogen, vascular endothelial growth factor (VEGF), was also assessed. RESULTS:Varying rates of endothelialization among comparator DES were most notable at 14 days, where coverage above struts remained poor in SES, PES, and ZES (or=70%), whereas no significant differences were observed at 28 days. Select DES with poor endothelialization showed a further reduced expression of PECAM-1. All DES showed an absence or weak expression of the antithrombotic cofactor TM. Incomplete endothelialization in select DES was further associated with increased VEGF secretion and messenger ribonucleic acid levels at 14 days, providing evidence of a transitional healing surface. CONCLUSIONS:The present study marks the first comparator analysis of endothelial coverage in leading polymeric DES, supporting disparities in arterial healing based on endothelial regrowth and recovery, favoring newer designs over the current generation of FDA-approved stents.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Joner M,Nakazawa G,Finn AV,Quee SC,Coleman L,Acampado E,Wilson PS,Skorija K,Cheng Q,Xu X,Gold HK,Kolodgie FD,Virmani R

doi

10.1016/j.jacc.2008.04.030

subject

Has Abstract

pub_date

2008-07-29 00:00:00

pages

333-42

issue

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(08)01703-8

journal_volume

pub_type

杂志文章

在线工具

Endothelial cell recovery between comparator polymer-based drug-eluting stents.