Abstract:
:The effects of metoprolol treatment in patients surviving acute myocardial infarction have been investigated in a double-blind randomized study. The patients were stratified according to age, infarct size and type of ventricular arrhythmias before administration of metoprolol, 100 mg twice daily (n = 154), or placebo (n = 147). All patients were followed up for 36 months. There were 31 (29 cardiac) and 25 (20 cardiac) deaths in the placebo and metoprolol groups, respectively. Subgroup analyses showed a significant reduction of cardiac death in patients with a large infarct (32.1% with placebo versus 12.5% with metoprolol, p less than 0.05) as a result of active treatment. Sudden death rates were 14.7% in the placebo versus 5.8% in the metoprolol group (p less than 0.05). The incidence of nonfatal reinfarction was 21.1% in the placebo versus 11.7% in the metoprolol group (p less than 0.05). The reduction in nonfatal reinfarction was similar in all pretreatment risk strata. The difference between the two groups in cumulative number of cardiac deaths and patients experiencing nonfatal reinfarction increased throughout the study. Furthermore, cerebrovascular events (p less than 0.05) and coronary bypass surgery (p = 0.058) were more frequent in the placebo group. In conclusion, after 36 months of metoprolol treatment after myocardial infarction, there was a significant reduction of nonfatal reinfarction and sudden death in all patients and a reduction of cardiac death in those with a large infarct.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Olsson G,Rehnqvist N,Sjögren A,Erhardt L,Lundman Tdoi
10.1016/s0735-1097(85)80360-0subject
Has Abstractpub_date
1985-06-01 00:00:00pages
1428-37issue
6eissn
0735-1097issn
1558-3597pii
S0735-1097(85)80360-0journal_volume
5pub_type
临床试验,杂志文章,随机对照试验abstract:OBJECTIVES:To compare seven-year survival in the Bypass Angioplasty Revascularization Investigation (BARI) patients randomly assigned to percutaneous transluminal coronary angioplasty (PTCA) versus coronary artery bypass grafting (CABG). BACKGROUND:The primary results of BARI reported no significant difference in five...
journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0735-1097(00)00533-7
更新日期:2000-04-01 00:00:00
abstract::With the current trend to performing surgical valvotomy for infantile aortic stenosis without cardiac catheterization, there is a need to develop echocardiographic criteria for adequacy of left ventricular size. The echocardiograms and catheterization data of all 25 infants less than 3 months of age undergoing aortic ...
journal_title:Journal of the American College of Cardiology
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doi:10.1016/0735-1097(91)90765-2
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abstract:OBJECTIVES:The goal of this study was to assess mechanisms underlying atrial fibrillation (AF) promotion by exercise training in an animal model. BACKGROUND:High-level exercise training promotes AF, but the underlying mechanisms are unclear. METHODS:AF susceptibility was assessed by programmed stimulation in rats aft...
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journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章
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更新日期:2004-02-18 00:00:00
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更新日期:2014-06-24 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.jacc.2004.04.044
更新日期:2004-08-04 00:00:00
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doi:10.1016/s0735-1097(83)80005-9
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pub_type: 杂志文章,评审
doi:10.1016/j.jacc.2010.11.011
更新日期:2011-02-15 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:1994-10-01 00:00:00
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更新日期:1999-06-01 00:00:00
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更新日期:2007-08-21 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2007-10-30 00:00:00
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journal_title:Journal of the American College of Cardiology
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doi:10.1016/s0735-1097(98)00408-2
更新日期:1998-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0735-1097(92)90254-k
更新日期:1992-11-15 00:00:00
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更新日期:2010-10-12 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:1993-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jacc.2013.08.1643
更新日期:2014-02-04 00:00:00
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doi:10.1016/0735-1097(88)90361-0
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pub_type: 杂志文章
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doi:10.1016/j.jacc.2004.09.060
更新日期:2005-01-18 00:00:00
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pub_type: 杂志文章
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更新日期:1994-04-01 00:00:00
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更新日期:2001-02-01 00:00:00
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更新日期:2007-11-06 00:00:00
abstract:OBJECTIVES:We administered pilsicainide chloride, a class Ic pure sodium channel blocker, to patients with Brugada syndrome (BS) and evaluated the occurrence of ventricular arrhythmia (VA) and T-wave alternans (TWA). BACKGROUND:Ventricular arrhythmia and TWA are sometimes induced by a sodium channel blocker challenge ...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2003.06.004
更新日期:2003-11-05 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(10)80111-1
更新日期:1991-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to determine whether the release of nitric oxide (NO) from the ischemic heart increases during exercise in patients with effort angina. BACKGROUND:Myocardial ischemia increases NO production in the canine heart, but no such increase has been demonstrated in the ischemic human heart...
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pub_type: 杂志文章
doi:10.1016/s0735-1097(98)00196-x
更新日期:1998-07-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-09-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2009.12.047
更新日期:2010-05-11 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(98)00441-0
更新日期:1998-11-15 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(94)90752-8
更新日期:1994-03-01 00:00:00