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Clinical Use of High-Sensitivity Cardiac Troponin in Patients With Suspected Myocardial Infarction.

Abstract：

:High-sensitivity cardiac troponin (hs-cTn) assays have been used clinically by thousands of physicians in many countries throughout the world since their clinical introduction 7 years ago. In the early diagnosis of myocardial infarction (MI), beyond doubt, the most important indication of hs-cTn assays, these simple, inexpensive, and highly reproducible tools complement detailed clinical assessment including chest pain characteristics and the electrocardiogram. Hs-cTn assays for the first time allowed the precise quantification of cardiomyocyte injury around the 99th percentile and thereby substantially increased the accuracy of MI detection from blood obtained at presentation to the emergency department (ED). Higher accuracy at ED presentation enabled the development and extensive validation of early hs-cTn-based diagnostic algorithms, which substantially reduced the time required for the safe rule-out or rule-in of MI. This review summarizes key principles underlying the safe and effective use of hs-cTn in the ED in patients with suspected MI.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Twerenbold R,Boeddinghaus J,Nestelberger T,Wildi K,Rubini Gimenez M,Badertscher P,Mueller C

doi

10.1016/j.jacc.2017.07.718

subject

Has Abstract

pub_date

2017-08-22 00:00:00

pages

996-1012

issue

8

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(17)38777-6

journal_volume

70

pub_type

杂志文章,评审

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