当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > Percutaneous radiofrequency septal reduction for hypertrophic obstructive cardiomyopathy in children.

Percutaneous radiofrequency septal reduction for hypertrophic obstructive cardiomyopathy in children.

Abstract：

OBJECTIVES:The aim of this study was to assess the efficacy of radiofrequency catheter ablation (RFCA) in the treatment of hypertrophic obstructive cardiomyopathy in children. BACKGROUND:Hypertrophic obstructive cardiomyopathy is an uncommon cause of left ventricular outflow tract obstruction in children. In symptomatic patients, open heart surgical myectomy has hitherto been the only therapeutic option. METHODS:In 32 children, at a median age of 11.1 (range 2.9 to 17.5) years and weight of 31 (15 to 68) kg, ablation of the hypertrophied septum was performed using a cool-tip ablation catheter via a femoral arterial approach. The median number of lesions was 27 (10 to 63) and fluoroscopic time was 24 (12 to 60) min. RESULTS:The majority of patients demonstrated an immediate decrease in the catheter pullback gradient (mean 78.5 ± 26.2 mm Hg pre-RFCA versus mean 36.1 ± 16.5 mm Hg post-RFCA, p < 0.01) and a further reduction in the Doppler echocardiographic gradient (mean 96.9 ± 27.0 mm Hg pre-RFCA versus 32.7 ± 27.1 mm Hg post-RFCA, p < 0.01) at follow-up. One patient died due to a paradoxical increase in left ventricular outflow tract obstruction, and another had persistent atrioventricular block that required permanent pacing. Six patients required further procedures (surgery, pacing, or further RFCA) during a median follow-up of 48 (3 to 144) months. CONCLUSIONS:The preliminary results of RFCA for septal reduction in children with hypertrophic cardiomyopathy are promising and merit further evaluation.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Sreeram N,Emmel M,de Giovanni JV

doi

10.1016/j.jacc.2011.09.020

subject

Has Abstract

pub_date

2011-12-06 00:00:00

pages

2501-10

issue

24

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(11)03340-7

journal_volume

58

pub_type

杂志文章

相关文献

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY文献大全
  • Genetically Confirmed Familial Hypercholesterolemia in Patients With Acute Coronary Syndrome.

    abstract：BACKGROUND:Genetic screening programs in unselected individuals with increased levels of low-density lipoprotein cholesterol (LDL-C) have shown modest results in identifying individuals with familial hypercholesterolemia (FH). OBJECTIVES:This study assessed the prevalence of genetically confirmed FH in patients with a...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2017.08.009

    authors： Amor-Salamanca A,Castillo S,Gonzalez-Vioque E,Dominguez F,Quintana L,Lluís-Ganella C,Escudier JM,Ortega J,Lara-Pezzi E,Alonso-Pulpon L,Garcia-Pavia P

    更新日期：2017-10-03 00:00:00

  • Extreme lipoprotein(a) levels and improved cardiovascular risk prediction.

    abstract：OBJECTIVES:The study tested whether extreme lipoprotein(a) levels and/or corresponding LPA risk genotypes improve myocardial infarction (MI) and coronary heart disease (CHD) risk prediction beyond conventional risk factors. BACKGROUND:Elevated lipoprotein(a) levels cause MI and CHD. Levels are primarily determined by ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2012.12.023

    authors： Kamstrup PR,Tybjærg-Hansen A,Nordestgaard BG

    更新日期：2013-03-19 00:00:00

  • Multivessel Palmaz-Schatz stenting: early results and one-year outcome.

    abstract：OBJECTIVES:To determine whether the benefits outlined in Background might extend to patients with multivessel disease, we examined the short- and long-term outcome of multivessel Palmaz-Schatz stenting. BACKGROUND:Percutaneous transluminal coronary angioplasty (PTCA) has become the dominant treatment for most patients...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(97)00146-0

    authors： Laham RJ,Ho KK,Baim DS,Kuntz RE,Cohen DJ,Carrozza JP Jr

    更新日期：1997-07-01 00:00:00

  • Coronary angioplasty and intracoronary thrombolysis are of limited efficacy in resolving early intracoronary stent thrombosis.

    abstract：OBJECTIVES:This study sought to evaluate treatment of early intracoronary stent thrombosis. BACKGROUND:Although refinements in intracoronary stent implantation technique and pharmacologic treatment have reduced the frequency of early stent thrombosis, stent thrombosis remains a feared complication of this procedure. O...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(96)00136-2

    authors： Hasdai D,Garratt KN,Holmes DR Jr,Berger PB,Schwartz RS,Bell MR

    更新日期：1996-08-01 00:00:00

  • Comparison of dual-chamber pacing versus septal myectomy for the treatment of patients with hypertrophic obstructive cardiomyopathy: a comparison of objective hemodynamic and exercise end points.

    abstract：OBJECTIVES:The purpose of this study was to compare the treatment effects of septal myectomy with dual-chamber pacing in patients with hypertrophic obstructive cardiomyopathy (HOCM). BACKGROUND:The optimal treatment for symptomatic patients with drug-refractory HOCM is unknown. Both dual-chamber pacing and surgical my...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(99)00173-4

    authors： Ommen SR,Nishimura RA,Squires RW,Schaff HV,Danielson GK,Tajik AJ

    更新日期：1999-07-01 00:00:00

  • Preinfarction angina as a major predictor of left ventricular function and long-term prognosis after a first Q wave myocardial infarction.

    abstract：OBJECTIVES:The purpose of this study was to assess the prognostic significance of preinfarction angina after a first Q wave myocardial infarction. Patients with anterior or inferior myocardial infarction were compared. BACKGROUND:The effect of preinfarction angina on prognosis after anterior and inferior myocardial in...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(95)80002-x

    authors： Anzai T,Yoshikawa T,Asakura Y,Abe S,Akaishi M,Mitamura H,Handa S,Ogawa S

    更新日期：1995-08-01 00:00:00

  • Benign congenital intracardiac thyroid and polycystic tumor causing right ventricular outflow tract obstruction and conduction disturbance.

    abstract：:A patient with a rare intracardiac tumor arising from the right side of the interventricular septum who developed conduction disturbances and symptoms of right ventricular outflow tract obstruction is reported. The patient was successfully treated with insertion of a permanent pacemaker and surgical removal of the tum...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(87)80105-5

    authors： Grigg LE,Downey W,Tatoulis J,Hunt D

    更新日期：1987-01-01 00:00:00

  • Antagonism of selectin function attenuates microvascular platelet deposition and platelet-mediated myocardial injury after transient ischemia.

    abstract：OBJECTIVES:The goal of this study was to assess whether selectin blockade reduces myocardial platelet deposition and platelet-mediated injury after transient ischemia. BACKGROUND:Selectins participate in platelet adhesion to reperfused endothelium. METHODS:Thiopental-anesthetized, open-chest pigs were subjected to me...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2004.09.068

    authors： Barrabés JA,Garcia-Dorado D,Mirabet M,Inserte J,Agulló L,Soriano B,Massaguer A,Padilla F,Lidón RM,Soler-Soler J

    更新日期：2005-01-18 00:00:00

  • Recombinant antibodies to an oxidized low-density lipoprotein epitope induce rapid regression of atherosclerosis in apobec-1(-/-)/low-density lipoprotein receptor(-/-) mice.

    abstract：OBJECTIVES:The present study tested the hypothesis that treatment with human recombinant immunoglobulin G1 (IgG1) antibodies against a specific oxidized low-density lipoprotein (oxLDL) epitope will induce regression of existing atherosclerotic lesions in LDL receptor-deficient mice expressing apolipoprotein B-100 (apoB...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2007.07.081

    authors： Schiopu A,Frendéus B,Jansson B,Söderberg I,Ljungcrantz I,Araya Z,Shah PK,Carlsson R,Nilsson J,Fredrikson GN

    更新日期：2007-12-11 00:00:00

  • Effect of streptokinase on left ventricular modeling and function after myocardial infarction: the GISSI (Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico) Trial.

    abstract：:It has been shown that streptokinase administration at the time of acute myocardial infarction reduces mortality significantly, and that this reduction in mortality should be related to salvage of jeopardized myocardium and preservation of left ventricular function. To better define the relation between thrombolytic t...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0735-1097(89)90409-9

    authors： Marino P,Zanolla L,Zardini P

    更新日期：1989-11-01 00:00:00

  • The electrophysiologic mechanism of ST-segment elevation in Brugada syndrome.

    abstract：OBJECTIVES:We sought to demonstrate the electrophysiologic (EP) mechanism of the ST-T change in Brugada syndrome. BACKGROUND:Brugada syndrome is characterized by various electrocardiographic manifestations (e.g., right bundle branch block, ST-segment elevation, and terminal T-wave inversion in the right precordial lea...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(02)01964-2

    authors： Kurita T,Shimizu W,Inagaki M,Suyama K,Taguchi A,Satomi K,Aihara N,Kamakura S,Kobayashi J,Kosakai Y

    更新日期：2002-07-17 00:00:00

  • Short-Term Exposure to Ambient Air Pollution and Mortality From Myocardial Infarction.

    abstract：BACKGROUND:Short-term exposure to ambient air pollution has been linked to occurrence of myocardial infarction (MI); however, only a limited number of studies investigated its association with death from MI, and the results remain inconsistent. OBJECTIVES:This study sought to investigate the association of short-term ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2020.11.033

    authors： Liu Y,Pan J,Fan C,Xu R,Wang Y,Xu C,Xie S,Zhang H,Cui X,Peng Z,Shi C,Zhang Y,Sun H,Zhou Y,Zhang L

    更新日期：2021-01-26 00:00:00

  • ST-segment deviation analysis of the admission 12-lead electrocardiogram as an aid to early diagnosis of acute myocardial infarction with a cardiac magnetic resonance imaging gold standard.

    abstract：OBJECTIVES:The purpose of this study was to validate existing 12-lead electrocardiographic (ECG) ST-segment elevation myocardial infarction (STEMI) criteria in the diagnosis of acute myocardial infarction (AMI) and the application of similar ST-segment depression (STEMI-equivalent) criteria with contrast-enhanced cardi...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2007.04.090

    authors： Martin TN,Groenning BA,Murray HM,Steedman T,Foster JE,Elliot AT,Dargie HJ,Selvester RH,Pahlm O,Wagner GS

    更新日期：2007-09-11 00:00:00

  • A mutation in CALM1 encoding calmodulin in familial idiopathic ventricular fibrillation in childhood and adolescence.

    abstract：OBJECTIVES:This study aimed to identify the genetic defect in a family with idiopathic ventricular fibrillation (IVF) manifesting in childhood and adolescence. BACKGROUND:Although sudden cardiac death in the young is rare, it frequently presents as the first clinical manifestation of an underlying inherited arrhythmia...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2013.07.091

    authors： Marsman RF,Barc J,Beekman L,Alders M,Dooijes D,van den Wijngaard A,Ratbi I,Sefiani A,Bhuiyan ZA,Wilde AA,Bezzina CR

    更新日期：2014-01-28 00:00:00

  • Dobutamine stress echocardiography predicts reversible dysfunction and quantitates the extent of irreversibly damaged myocardium after reperfusion of anterior myocardial infarction.

    abstract：OBJECTIVES:This study was designed to evaluate dobutamine stress echocardiography in identifying reversible dysfunction and assessing the extent of irreversibly damaged myocardium early in acute myocardial infarction. BACKGROUND:Several experimental and clinical studies have suggested that dobutamine enhances contract...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(94)90006-x

    authors： Watada H,Ito H,Oh H,Masuyama T,Aburaya M,Hori M,Iwakura M,Higashino Y,Fujii K,Minamino T

    更新日期：1994-09-01 00:00:00

  • Randomized trials of directional coronary atherectomy: implications for clinical practice and future investigation.

    abstract：OBJECTIVES:This study compared and contrasted the randomized trials of directional atherectomy and coronary angioplasty for de novo native coronary artery lesions. BACKGROUND:The results of two randomized trials, the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT) and the Canadian Coronary Atherectom...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/0735-1097(94)90300-x

    authors： Holmes DR Jr,Topol EJ,Adelman AG,Cohen EA,Califf RM

    更新日期：1994-08-01 00:00:00

  • A randomized, double-blind, multicenter comparison study of triple antiplatelet therapy with dual antiplatelet therapy to reduce restenosis after drug-eluting stent implantation in long coronary lesions: results from the DECLARE-LONG II (Drug-Eluting Sten

    abstract：OBJECTIVES:The purpose of this study was to determine whether cilostazol reduces intimal hyperplasia in patients undergoing long zotarolimus-eluting stent implantation (stent length: ≥ 30 mm) for native long coronary lesions (length: ≥ 25 mm). BACKGROUND:Restenosis after drug-eluting stent implantation remains a signi...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jacc.2010.10.035

    authors： Lee SW,Park SW,Kim YH,Yun SC,Park DW,Lee CW,Kang SJ,Park SJ,Lee JH,Choi SW,Seong IW,Lee NH,Cho YH,Shin WY,Lee SJ,Lee SW,Hyon MS,Bang DW,Choi YJ,Kim HS,Lee BK,Lee K,Park HK,Park CB,Lee SG,Kim MK,Park KH

    更新日期：2011-03-15 00:00:00

  • Inhaled nitric oxide and hemodynamic evaluation of patients with pulmonary hypertension before transplantation.

    abstract：OBJECTIVES:We investigated the effect of inhaled nitric oxide and infused acetylcholine in patients with pulmonary hypertension undergoing cardiac catheterization before cardiopulmonary transplantation. BACKGROUND:The fate of patients under consideration for transplantation of the heart or lungs, or both, is influence...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(95)00048-9

    authors： Adatia I,Perry S,Landzberg M,Moore P,Thompson JE,Wessel DL

    更新日期：1995-06-01 00:00:00

  • Aspirin resistance and atherothrombotic disease.

    abstract：:Acute coronary syndromes and other manifestations of atherothrombotic disease are primarily caused by atherosclerotic plaque rupture or fissuring and subsequent occlusive or subocclusive thrombus formation. Platelets play a critical role in the pathophysiology of atherothrombotic disease, and aspirin is the most commo...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2004.08.070

    authors： Mason PJ,Jacobs AK,Freedman JE

    更新日期：2005-09-20 00:00:00

  • Effects of left ventricular asynchrony on time constant and extrapolated pressure of left ventricular pressure decay in coronary artery disease.

    abstract：:To elucidate the effects of ventricular asynchrony with or without myocardial ischemia on the time constant of left ventricular pressure decay and asymptote, that is, the level to which pressure would decrease if isovolumic pressure decrease continued infinitely, left ventriculography and pressure measurements were in...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(85)80118-2

    authors： Takeuchi M,Fujitani K,Kurogane K,Bai HT,Toda C,Yamasaki T,Fukuzaki H

    更新日期：1985-09-01 00:00:00

  • Accurate estimates of absolute left ventricular volumes from equilibrium radionuclide angiographic count data using a simple geometric attenuation correction.

    abstract：:To simplify and clarify the methods of obtaining attenuation-corrected equilibrium radionuclide angiographic estimates of absolute left ventricular volumes, 27 patients who also had biplane contrast cineangiography were evaluated. Background-corrected left ventricular end-diastolic and end-systolic counts were obtaine...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(84)80256-9

    authors： Starling MR,Dell'Italia LJ,Walsh RA,Little WC,Benedetto AR,Nusynowitz ML

    更新日期：1984-03-01 00:00:00

  • Revascularization of chronic hibernating myocardium stimulates myocyte proliferation and partially reverses chronic adaptations to ischemia.

    abstract：BACKGROUND:The time course and extent of recovery after revascularization of viable dysfunctional myocardium are variable. Although fibrosis is a major determinant, myocyte structural and molecular remodeling may also play important roles. OBJECTIVES:This study sought to determine whether persistent myocyte loss and/o...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2014.11.040

    authors： Page BJ,Banas MD,Suzuki G,Weil BR,Young RF,Fallavollita JA,Palka BA,Canty JM Jr

    更新日期：2015-02-24 00:00:00

  • Urocortin promotes hemodynamic and bioenergetic recovery and improves cell survival in the isolated rat heart exposed to ischemia/reperfusion.

    abstract：OBJECTIVES:This study evaluates the hemodynamic, bioenergetic and cytoprotective effects of urocortin (Ucn) in the isolated rat heart exposed to ischemia (I)/reperfusion (R). BACKGROUND:We have previously demonstrated that administration of exogenous Ucn reduces infarct size in ischemic-reperfused rat hearts. METHODS...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(02)01930-7

    authors： Scarabelli TM,Pasini E,Stephanou A,Comini L,Curello S,Raddino R,Ferrari R,Knight R,Latchman DS

    更新日期：2002-07-03 00:00:00

  • Pulmonary artery growth after palliation of congenital heart disease with duct-dependent pulmonary circulation: arterial duct stenting versus surgical shunt.

    abstract：OBJECTIVES:The aim of this study was to compare the pulmonary artery (PA) growth after arterial duct (AD) stenting versus modified Blalock-Taussig shunt (MBTS) in neonates with congenital heart disease with duct-dependent pulmonary circulation (CHD-DPC). BACKGROUND:Arterial duct stenting is increasingly deemed a relia...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2009.07.043

    authors： Santoro G,Capozzi G,Caianiello G,Palladino MT,Marrone C,Farina G,Russo MG,Calabrò R

    更新日期：2009-12-01 00:00:00

  • Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes.

    abstract：BACKGROUND:Subclinical inflammation mediated in part by interleukin (IL)-1β participates in peripheral insulin resistance and impaired pancreatic insulin secretion. OBJECTIVES:The authors tested the hypothesis that the IL-1β inhibitor canakinumab reduces incident diabetes. METHODS:The authors randomized 10,061 patien...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jacc.2018.03.002

    authors： Everett BM,Donath MY,Pradhan AD,Thuren T,Pais P,Nicolau JC,Glynn RJ,Libby P,Ridker PM

    更新日期：2018-05-29 00:00:00

  • Simulation of acute myopericarditis by constrictive pericardial disease with endomyocardial fibrosis due to methysergide therapy.

    abstract：:Methysergide ( Sansert ) has been associated with numerous fibrotic disorders. In particular, multiple cardiac lesions have been described in cases where methysergide was thought to have played a causative role. A patient is described who presented with cardiac findings suggestive of acute myopericarditis . An inflamm...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(84)80342-3

    authors： Harbin AD,Gerson MC,O'Connell JB

    更新日期：1984-07-01 00:00:00

  • Are residual stenoses after excimer laser angioplasty and coronary atherectomy due to inefficient or small devices? Comparison with balloon angioplasty.

    abstract：OBJECTIVES:The purpose of this study was to determine whether residual stenoses after excimer laser angioplasty and atherectomy were due to inefficient tissue ablation/removal or to undersized devices. BACKGROUND:Significant residual stenoses are commonly observed after use of laser and atherectomy devices. It is not ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(93)90587-q

    authors： Safian RD,Freed M,Lichtenberg A,May MA,Juran N,Grines CL,O'Neill WW

    更新日期：1993-11-15 00:00:00

  • Progressive decreases in coronary vein flow during reperfusion in acute myocardial infarction: clinical documentation of the no reflow phenomenon after successful thrombolysis.

    abstract：OBJECTIVES:This study was undertaken to examine the effects of coronary flow dynamics after thrombolysis on infarct size limitation. BACKGROUND:It has been commonly accepted that early thrombolysis does not necessarily salvage infarcted myocardium. Plausible causes for myocardial necrosis include such factors as elaps...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0735-1097(94)90290-9

    authors： Komamura K,Kitakaze M,Nishida K,Naka M,Tamai J,Uematsu M,Koretsune Y,Nanto S,Hori M,Inoue M

    更新日期：1994-08-01 00:00:00

  • Pulmonary artery origin of the left coronary artery: diagnosis by two-dimensional echocardiography, pulsed Doppler ultrasound and color flow mapping.

    abstract：:Five children, aged 0.2 to 6.7 years, with pulmonary artery origin of the left coronary artery proved by angiography underwent echocardiographic examination from 1985 through 1986. Prospective identification of this condition was achieved by two-dimensional echocardiography alone in two patients. Using a parasagittal ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(88)90108-8

    authors： Schmidt KG,Cooper MJ,Silverman NH,Stanger P

    更新日期：1988-02-01 00:00:00

  • A clinical and echocardiographic score for assigning risk of major events after dobutamine echocardiograms.

    abstract：OBJECTIVES:We sought to develop and validate a risk score combining both clinical and dobutamine echocardiographic (DbE) features in 4890 patients who underwent DbE at three expert laboratories and were followed for death or myocardial infarction for up to five years. BACKGROUND:In contrast to exercise scores, no scor...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2004.02.040

    authors： Marwick TH,Case C,Poldermans D,Boersma E,Bax J,Sawada S,Thomas JD

    更新日期：2004-06-02 00:00:00