Acetylcholine and norepinephrine concentrations in the heart of spontaneously hypertensive rats: a parasympathetic role in hypertension.

abstract：OBJECTIVES:We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). METHODS:We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HA...

journal_title：Journal of hypertension

authors： Parthasarathy HK,Alhashmi K,McMahon AD,Struthers AD,McInnes GT,Ford I,Connell JM,MacDonald TM

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Primary hypertension is a hereditary disorder characterized by a complex etiological interplay of multiple genetic and environmental factors, until now defying attempts at identifying pathogenetically important genes. The marriage of classical genetics and molecular techniques is now offering a powerful set ...

journal_title：Journal of hypertension

authors： Lindpaintner K

更新日期：1992-02-01 00:00:00

abstract：:If ambulatory blood pressure measurement is not possible because the upper-arm circumference is so great that even the largest cuff provided with the monitor will not encircle the arm, satisfactory measurements can be obtained by applying a cuff to the forearm. ...

journal_title：Journal of hypertension

authors： O'Brien E

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:The antihypertensive effect of thiazide diuretics in angiotensin II induced hypertension has never been characterized. In the current study, we sought to determine the effect of a thiazide diuretic on arterial pressure and renal fluid excretion in rats receiving a chronic intravenous infusion of angiotensin ...

journal_title：Journal of hypertension

authors： Ballew JR,Fink GD

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:We examined the effects of treatment with soluble epoxide hydrolase inhibitor (sEHi) and epoxyeicosatrienoic acids (EETs) analogue (EET-A), given alone or combined, on blood pressure (BP) and ischemia/reperfusion myocardial injury in rats with angiotensin II (ANG II)-dependent hypertension. METHODS:Ren-2 tra...

journal_title：Journal of hypertension

authors： Červenka L,Husková Z,Kopkan L,Kikerlová S,Sedláková L,Vaňourková Z,Alánová P,Kolář F,Hammock BD,Hwang SH,Imig JD,Falck JR,Sadowski J,Kompanowska-Jezierska E,Neckář J

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To determine if the contribution of the sympathetic nervous system to blood pressure could be evidenced by low-frequency oscillations of systolic blood pressure (LF(SBP)), reflecting vascular sympathetic modulation, or by the decrease in blood pressure after autonomic blockade. DESIGN:We studied multiple sys...

journal_title：Journal of hypertension

authors： Diedrich A,Jordan J,Tank J,Shannon JR,Robertson R,Luft FC,Robertson D,Biaggioni I

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:Blood pressure (BP) load, defined as the percentage of abnormally elevated BP readings, is usually provided on the report of ambulatory BP monitoring. However, the usefulness of BP load is still uncertain. In the present study, we examined whether BP load would be associated, independently of BP level, with t...

journal_title：Journal of hypertension

authors： Liu M,Li Y,Wei FF,Zhang L,Han JL,Wang JG

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:Studies were undertaken to clarify the pathophysiologic significance of endogenous endothelin in the control of blood pressure and renal hemodynamics in spontaneously hypertensive rats (SHR). DESIGN:The technique of passive immunization was used to neutralize endogenous endothelin in order to estimate the co...

journal_title：Journal of hypertension

authors： Ohno A,Naruse M,Kato S,Hosaka M,Naruse K,Demura H,Sugino N

更新日期：1992-08-01 00:00:00

abstract：OBJECTIVE:To estimate the arterial blood pressure, left ventricular function and insulin secretion in alcoholics. DESIGN:We examined hospitalized patients between the second and seventh day of acute alcohol withdrawal and after a month of abstinence by 24 h ambulatory blood pressure monitoring, a standard oral glucose...

journal_title：Journal of hypertension

authors： Rajzer M,Kawecka-Jaszcz K,Czarnecka D,Dragan J,Betkowska B

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Cardiovascular diseases represent the most common cause of death in the English-speaking Caribbean, and hypertension represents the most important predisposing condition. However, direct between-country comparative studies in the Caribbean have not previously been undertaken. OBJECTIVE:To obtain estimates o...

journal_title：Journal of hypertension

authors： Freeman V,Fraser H,Forrester T,Wilks R,Cruickshank J,Rotimi C,Cooper R

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The present study clarifies associations between stroke outcomes after intravenous tissue plasminogen activator (tPA) and blood pressure (BP) as well as heart rate (HR) profiles. METHODS:We assessed 125 patients with stroke who received tPA within 3 h of onset. We obtained baseline, mean, maximu...

journal_title：Journal of hypertension

authors： Tomii Y,Toyoda K,Nakashima T,Nezu T,Koga M,Yokota C,Nagatsuka K,Minematsu K

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVES:Recent evidence indicates that reduced sleep duration may be associated with an increased risk of hypertension with possibly stronger effects among women than men. We therefore examined cross-sectional sex-specific associations of sleep duration with hypertension in a large population-based sample from the W...

journal_title：Journal of hypertension

authors： Stranges S,Dorn JM,Cappuccio FP,Donahue RP,Rafalson LB,Hovey KM,Freudenheim JL,Kandala NB,Miller MA,Trevisan M

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVES:We examined whether the early initiation of sexual activity is associated with hypertension in US adults, and whether the timing of first menstruation is meaningful in regard of this association. We also assessed the effect modification by ethnicity. METHODS:Using data from 2001 to 2016 National Health and ...

journal_title：Journal of hypertension

authors： Ngueta G,Ndjaboue R

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:Intermedin (IMD), a novel member of the calcitonin/calcitonin gene-related peptide family, is involved in maintaining circulatory homeostasis and is a protective factor of heart and vessel. Here, we investigated the effects of IMD on cardiac hypertrophy in vivo and in vitro and explored the mechanisms involve...

journal_title：Journal of hypertension

authors： Lu WW,Zhao L,Zhang JS,Hou YL,Yu YR,Jia MZ,Tang CS,Qi YF

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:Lower parental education is associated with higher adolescent blood pressure (BP). We examined the contribution of modifiable risk factors from infancy to adolescence that could potentially explain the link between parental education and SBP and DBP in the offspring. METHODS:In a prospective Chinese birth c...

journal_title：Journal of hypertension

authors： Kwok MK,Schooling CM,Subramanian SV,Leung GM,Kawachi I

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:To measure blood pressure accurately, by developing a new algorithm and an indirect method employing a non-elastic cuff with a photosensor. DESIGN AND METHODS:A non-elastic cuff was wrapped around the brachium. A reflecting plate (10 mm x 40 mm) was sited on the inner central part of the cuff on the arterial...

journal_title：Journal of hypertension

authors： Tochikubo O,Kawano Y,Miyajima E,Ishii M

更新日期：1997-02-01 00:00:00

abstract：:Isolated tail arteries from stroke-prone spontaneously hypertensive rats (SHRSP), but not from normotensive Wistar-Kyoto rats (WKY), exhibit oscillatory contractions in response to norepinephrine. Previous studies indicate that the mechanism for these oscillations involves altered membrane calcium and/or potassium han...

journal_title：Journal of hypertension

authors： Bruner CA,Webb RC

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:Enhanced central sympathetic outflow is an indicator of the prognosis of heart failure. Although the central sympatholytic drug moxonidine is an established therapeutic strategy for hypertension, its benefits for hypertensive heart failure are poorly understood. In the present study, we investigated the effe...

journal_title：Journal of hypertension

authors： Honda N,Hirooka Y,Ito K,Matsukawa R,Shinohara K,Kishi T,Yasukawa K,Utsumi H,Sunagawa K

更新日期：2013-11-01 00:00:00

abstract：INTRODUCTION:Combination therapy is needed to control blood pressure (BP) in a large number of hypertensive patients with diabetes mellitus. Adherence to treatment is a major clinical problem; therefore, the time duration of the antihypertensive action of a drug determines BP control when a dose is skipped. OBJECTIVES...

journal_title：Journal of hypertension

authors： Redon J,Pichler G,Missed Dose Study Group.

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:Previous studies on multicellular preparations have shown that hypertrophied cardiac muscle from the spontaneously hypertensive rat (SHR) has a prolonged action potential. The first aim of the present study was to determine whether the action potential of isolated left ventricular myocytes was similarly prolo...

journal_title：Journal of hypertension

authors： Brooksby P,Levi AJ,Jones JV

更新日期：1993-06-01 00:00:00

abstract：OBJECTIVE:We tested the reproducibility of ambulatory blood pressure (ABP), BP variability, and BP reduction in hypertensive patients. METHODS:Forty-two hypertensive patients were enrolled, and ABP monitoring (ABPM) was performed four times in each patient: twice before and twice after the treatment. Morning BP was de...

journal_title：Journal of hypertension

authors： Eguchi K,Hoshide S,Hoshide Y,Ishikawa S,Shimada K,Kario K

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the association between stroke risk and blood pressure (BP) levels with regard to the usage of antihypertensive medications. METHODS:From the Japan arteriosclerosis longitudinal study, 11,371 participants from the four population-based cohort studies (aged 40-89) were followed up for a mean of 9....

journal_title：Journal of hypertension

authors： Asayama K,Ohkubo T,Yoshida S,Suzuki K,Metoki H,Harada A,Murakami Y,Ohashi Y,Ueshima H,Imai Y,Japan Arteriosclerosis Longitudinal Study (JALS) group.

更新日期：2009-02-01 00:00:00

abstract：:Ischemic renal disease (IRD) is defined as a clinically important reduction in glomerular filtration rate or loss of renal parenchyma caused by hemodynamically significant renal artery stenosis. IRD is a common and often overlooked clinical entity that presents itself in the setting of extrarenal arteriosclerotic vasc...

journal_title：Journal of hypertension

authors： Preston RA,Epstein M

更新日期：1997-12-01 00:00:00

abstract：:The present study was designed to investigate in rats the influence of converting enzyme inhibition with captopril on blood pressure, plasma urea, plasma renin concentration (PRC), plasma aldosterone and plasma vasopressin, and to define the interrelationships between PRC and these variables during equal degrees of ei...

journal_title：Journal of hypertension

authors： Gardes J,Gonzalez MF,Corvol P,Ménard J

更新日期：1986-04-01 00:00:00

abstract：:Haemorheological characteristics were measured in a group of 52 patients with essential arterial hypertension (HT), and were compared with those of a group of normotensive subjects. The relationships between the arterial blood pressure (BP), the echocardiographic indices of left ventricular hypertrophy (LVH), and the ...

journal_title：Journal of hypertension

authors： Zannad F,Voisin P,Brunotte F,Bruntz JF,Stoltz JF,Gilgenkrantz JM

更新日期：1988-04-01 00:00:00

abstract：:Angioplasty of renal artery stenosis has been used extensively in the last two decades for treating renovascular hypertension, and, more recently, for preserving the jeopardized renal function. A large body of evidence has accumulated indicating that this approach is by far the most convenient for patients with fibrom...

journal_title：Journal of hypertension

authors： Morganti A

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:The acute effects of estrogen on hemodynamic responses were studied with emphasis on the sympathoadrenal system and peripheral circulation. DESIGN:Eleven healthy postmenopausal women recruited from the population-based study BEDA were included in this randomized, double-blind, cross-over, placebo-controlled ...

journal_title：Journal of hypertension

authors： Manhem K,Brandin L,Ghanoum B,Rosengren A,Gustafsson H

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Cross-sectional studies of the association between hypertension (HTN) and brain atrophy have shown reductions in prefrontal, temporal, and hippocampal volumes, and have identified thinner cortices across the cortical mantle. METHOD:In the current study, we followed 96 participants enrolled in the Baltimore ...

journal_title：Journal of hypertension

authors： Gonzalez CE,Pacheco J,Beason-Held LL,Resnick SM

更新日期：2015-06-01 00:00:00

abstract：:BMI represents an internal metabolic and physiological environment that plays a key role in development of high blood pressure (BP) for many Americans. African-American women have a higher prevalence of high BP and being overweight than men or other ethnic groups. This study examines the genetic-environmental interact...

journal_title：Journal of hypertension

authors： Taylor J,Sun YV,Chu J,Mosley TH,Kardia SL

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:We have previously reported that hearts from N-[omega]-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats exhibited an enhanced expression of Gi proteins. Since, losartan, an AT1 receptor antagonist, has been shown to attenuate the L-NAME-induced increase in blood pressure, we undertook the pres...

journal_title：Journal of hypertension

authors： Hashim S,Anand-Srivastava MB

更新日期：2004-01-01 00:00:00