8-Hydroxy-2'-deoxy-guanosine is a risk factor for development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection.

abstract：BACKGROUND:Habitual alcohol intake is known to aggravate the clinical outcome of hepatitis C virus (HCV)-related chronic liver diseases and to increase the risk of hepatocellular carcinoma. METHODS:To investigate the possible mechanism of these effects by alcohol, we examined 31 cases of HCV-related chronic liver dise...

journal_title：Journal of gastroenterology and hepatology

authors： Takahashi K,Takahashi T,Takahashi S,Watanabe K,Boku S,Matsui S,Arai F,Asakura H

更新日期：2001-04-01 00:00:00

abstract：:Sinusoidal endothelial cell damage is produced by activation of hepatic macrophages after endotoxin administration in rats pretreated with Cornyebacterium parvum or undergoing 70% hepatectomy. Such damage causes fibrin deposition in the hepatic sinusoids leading to massive hepatic necrosis. In the C. parvum model, cyt...

journal_title：Journal of gastroenterology and hepatology

authors： Mochida S,Ohno A,Arai M,Fujiwara K

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Currently, hepatitis B immunoglobulins (HBIg) and/or lamivudine have become the main options for prevention of hepatitis B recurrence after liver transplantation. AIM:To assess the benefits of HBIg and/or lamivudine for prevention of hepatitis B recurrence after liver transplantation. METHODS:We conducted ...

journal_title：Journal of gastroenterology and hepatology

authors： Chen J,Yi L,Jia JD,Ma H,You H

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND AIM:On endoscopic ultrasound (EUS)-guided biliary drainage, fistula dilation may be accompanied by leakage of bile juice, potentially along with bacteria or air, so this procedure should be kept as simple and short as possible. To date, various techniques to dilate the fistula have been reported. This pr...

journal_title：Journal of gastroenterology and hepatology

authors： Amano M,Ogura T,Onda S,Takagi W,Sano T,Okuda A,Miyano A,Masuda D,Higuchi K

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND AND AIM:Dendritic cells (DCs) are observed on the Helicobacter pylori-infected gastric mucosa. DCs generally play an important role in the regulation of inflammation. Although stimulation of gastric epithelial cells with H. pylori vacuolating cytotoxin (VacA) has been reported to induce apoptosis and endopla...

journal_title：Journal of gastroenterology and hepatology

authors： Kim JM,Kim JS,Kim N,Ko SH,Jeon JI,Kim YJ

更新日期：2015-01-01 00:00:00

abstract：:Wilson's disease is an autosomal recessive, inborn error of copper metabolism. The basic defect is unknown but decreased biliary excretion of copper is associated with copper accumulation and damage to the liver, brain and other organs with variable clinical expression. The gene for the disease has been mapped to band...

journal_title：Journal of gastroenterology and hepatology

authors： Frydman M

更新日期：1990-07-01 00:00:00

abstract：:Spontaneous regression of hepatocellular carcinoma (HCC) is a rare phenomenon. This case of a 65-year-old Korean man with HCC and metastatic frontal bone mass that regressed after radiotherapy for frontal bone mass without any other therapeutic modalities is described. The clinical diagnosis of HCC was made because of...

journal_title：Journal of gastroenterology and hepatology

authors： Nam SW,Han JY,Kim JI,Park SH,Cho SH,Han NI,Yang JM,Kim JK,Choi SW,Lee YS,Chung KW,Sun HS

更新日期：2005-03-01 00:00:00

abstract：:A 54-year-old woman who was being treated with 10 million units (mu) of natural interferon (IFN)-alpha per day for chronic active hepatitis C at a local clinic, developed coma on the fourth day of treatment. On admission to Yamagata University Hospital, she was still in a state of semicoma with severe hyponatraemia (1...

journal_title：Journal of gastroenterology and hepatology

authors： Mabe K,Shinzawa H,Yamatani K,Takeda T,Ishibashi M,Yamada N,Misawa H,Wakabayashi H,Togashi H,Takahashi T

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND AND AIM:Serum cancer antigen (CA) 125 elevation has been reported in patients with liver disease, but it is poorly characterized. The present study aimed to evaluate the range of serum and ascitic CA 125 levels in patients with liver cirrhosis and to explore possible factors associated with CA 125 elevation....

journal_title：Journal of gastroenterology and hepatology

authors： Xiao WB,Liu YL

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND AND AIM:Cytokines play an important role in the pathogenesis of acute pancreatitis (AP). The aim of the present paper was to study the profile of anti- and proinflammatory cytokines in AP and to determine their predictive value for severity of AP, organ failure and mortality. METHODS:Consecutive patients wi...

journal_title：Journal of gastroenterology and hepatology

authors： Sathyanarayan G,Garg PK,Prasad H,Tandon RK

更新日期：2007-04-01 00:00:00

abstract：:The hepatitis C virus was first identified in 1989. It causes chronic hepatitis, cirrhosis and hepatocellular carcinoma. Global anti-HCV prevalence is 1-3%. Contaminated blood product, dirty needles and instruments, and injection drug use are the main parenteral routes of transmission. Cultural practices, such as acup...

journal_title：Journal of gastroenterology and hepatology

authors： Leung NW

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Biliary disease is one of the most common causes of acute pancreatitis in adults; however, this cause and outcome in children have rarely been described in the literature. Therefore, the present study was conducted to evaluate the role of biliary disease as a cause of acute pancreatitis in children....

journal_title：Journal of gastroenterology and hepatology

authors： Choi BH,Lim YJ,Yoon CH,Kim EA,Park YS,Kim KM

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Cancer invasion and metastasis are critical events for patient prognosis; however, the most important step in the whole process of lymph node (LN) metastasis in gastric cancer remains obscure. In this study, the significance of cancer cell behaviors, such as cell detachment, stromal invasion and lym...

journal_title：Journal of gastroenterology and hepatology

authors： Kamata I,Ishikawa Y,Akishima-Fukasawa Y,Ito K,Akasaka Y,Uzuki M,Fujimoto A,Morita H,Tamai S,Maehara T,Ogata K,Shimokawa R,Igarashi Y,Miki K,Ishii T

更新日期：2009-09-01 00:00:00

abstract：:The main purpose of the present study was to demonstrate the incidence of Paneth cells in colorectal tubular adenomas of Japanese descendants in Hawaii. Paneth cells were found in 73 of 322 adenomas (22.7%) of Japanese descendants in Hawaii. The incidence of Paneth cells in adenomas located from the caecum to the tran...

journal_title：Journal of gastroenterology and hepatology

authors： Wada R,Kuwabara N,Suda K

更新日期：1994-05-01 00:00:00

abstract：UNLABELLED:A case-control study was conducted in southern Thailand to test the hypothesis that alcohol consumption, smoking, rubber processing and nutritional deficiency were risk factors for oesophageal cancer. Cases (n = 40) were recruited from patients admitted to the University Hospital, where the first interview t...

journal_title：Journal of gastroenterology and hepatology

authors： Chongsuvivatwong V

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND AND AIMS:The aim of this study was to clinicopathologically distinguish the pathogenesis of gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma without a MALT lymphoma component (DLL). METHODS:We investigated clinicopathological features of these gastric lymphomas inc...

journal_title：Journal of gastroenterology and hepatology

authors： Hiyama T,Haruma K,Kitadai Y,Masuda H,Miyamoto M,Ito M,Kamada T,Tanaka S,Uemura N,Yoshihara M,Sumii K,Shimamoto F,Chayama K

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:The pathogenesis of non-alcoholic steatohepatitis (NASH) is unclear. Recent studies suggested that oxidative stress plays an important role in the mechanism of NASH. Excessive accumulation of iron in the liver causes oxidative stress. The aim of the present study was to evaluate the grade of hepatic iron acc...

journal_title：Journal of gastroenterology and hepatology

authors： Yamamoto M,Iwasa M,Iwata K,Kaito M,Sugimoto R,Urawa N,Mifuji R,Konishi M,Kobayashi Y,Adachi Y

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Hepatic steatosis is a histological characteristic in patients with chronic hepatitis C virus (HCV) infection. The aim of this study was to evaluate the prevalence of hepatic steatosis in Chinese patients with chronic hepatitis C, and to look for possible correlation with various histopathological c...

journal_title：Journal of gastroenterology and hepatology

authors： Hwang SJ,Luo JC,Chu CW,Lai CR,Lu CL,Tsay SH,Wu JC,Chang FY,Lee SD

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND AND AIM:Oral mucosal pathologies are frequent in inflammatory bowel disease (IBD). Since host-microbiome interactions are implicated in the pathogenesis of IBD, in this study the potential for changes affecting the oral microbiome was evaluated using two complementary mouse models of colitis: either chemical...

journal_title：Journal of gastroenterology and hepatology

authors： Rautava J,Pinnell LJ,Vong L,Akseer N,Assa A,Sherman PM

更新日期：2015-03-01 00:00:00

abstract：:One of the characteristic features of the majority of pancreatic ductal adenocarcinomas is an abundant desmoplastic/stromal reaction. Until recently, this stroma had received little attention from researchers studying the pathogenesis of pancreatic cancer, with most of the research focus resting on the biology of tumo...

journal_title：Journal of gastroenterology and hepatology

authors： Apte MV,Wilson JS

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Resistance of Helicobacter pylori to the standard therapeutic antimicrobial agents has been demonstrated. Although quinolones are an alternative candidate for third-line eradication therapy, quinolone resistance of H. pylori is also increasing. Quinolone resistance of H. pylori is caused by a point ...

journal_title：Journal of gastroenterology and hepatology

authors： Matsuzaki J,Suzuki H,Tsugawa H,Nishizawa T,Hibi T

更新日期：2010-05-01 00:00:00

abstract：:The aetiology of idiopathic portal hypertension or hepatoportal sclerosis is unknown. In view of the indirect evidence for underlying immunologic abnormalities 14 patients (all middle-aged females) were studied. Various auto-antibodies were demonstrated in seven patients and high levels of serum immunoglobulins, eithe...

journal_title：Journal of gastroenterology and hepatology

authors： Tokushige K,Komatsu T,Ohzu K,Yamauchi K,Obata H

更新日期：1992-05-01 00:00:00

abstract：:T regulatory cells (Tregs) play an important role in the regulation of autoimmunity, autoinflammation, allergic diseases, infection, and the tumor environment. Different subsets are characterized that use a number of regulatory mechanisms. Tregs can influence the progression of inflammatory bowel disease and the devel...

journal_title：Journal of gastroenterology and hepatology

authors： van Herk EH,Te Velde AA

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Hepatic steatosis is a metabolic liver disease with the potential to progress to steatohepatitis, cirrhosis, and hepatocellular carcinoma (HCC). The aim of this study was to investigate the impact of CCAAT/enhancer-binding protein homologous protein (CHOP) deficiency in the development of steatosis-...

journal_title：Journal of gastroenterology and hepatology

authors： Toriguchi K,Hatano E,Tanabe K,Takemoto K,Nakamura K,Koyama Y,Seo S,Taura K,Uemoto S

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:The liver is the major iron storage organ in the body and, as a result, total body iron stores closely regulate hepatocyte iron uptake, storage and release. Transferrin, transferrin receptor and ferritin facilitate these processes. METHODS:Expression of the three proteins was localized by immunohistochemist...

journal_title：Journal of gastroenterology and hepatology

authors： Basclain KA,Jeffrey GP

更新日期：1999-07-01 00:00:00

abstract：:The Korean College of Helicobacter and Upper Gastrointestinal Research first developed guidelines for the diagnosis and treatment of Helicobacter pylori (H. pylori) infection in 1998, and revised guidelines were proposed in 2009 by the same group. Although the revised guidelines were based on a comprehensive review of...

journal_title：Journal of gastroenterology and hepatology

authors： Kim SG,Jung HK,Lee HL,Jang JY,Lee H,Kim CG,Shin WG,Shin ES,Lee YC,Korean College of Helicobacter and Upper Gastrointestinal Research.

更新日期：2014-01-01 00:00:00

abstract：:Continuing advances in molecular biology have provided tools for a promising approach to the treatment of cancer. Among the various strategies of gene therapy for cancer, many are aimed at killing tumour cells indirectly by the induction or reinforcement of a host immune response by gene transduction of various cytoki...

journal_title：Journal of gastroenterology and hepatology

authors： Cao G,Kuriyama S,Du P,Sakamoto T,Yang W,Masui K,Qi Z

更新日期：1996-11-01 00:00:00

abstract：:The in vitro binding of 125I-labelled human alpha-interferon to peripheral blood mononuclear cells from 13 patients with chronic hepatitis B during interferon therapy was assayed in order to identify changes in the number of interferon receptors during treatment. Nine patients were treated with human alpha-interferon ...

journal_title：Journal of gastroenterology and hepatology

authors： Nakajima S,Kuroki T,Kurai O,Kobayashi K,Yamamoto S

更新日期：1989-09-01 00:00:00

abstract：:Despite steady progress in antiviral treatment for patients with chronic hepatitis C virus(HCV), many patients still have detectable serum HCV RNA levels by the end of interferon-based treatment and are known as virological non-responders. Re-treatment of these patients not responding to previous therapy remains chall...

journal_title：Journal of gastroenterology and hepatology

authors： Poo JL,Sánchez-Avila F,Kershenobich D,García-Samper X,Gongora J,Uribe M

更新日期：2004-12-01 00:00:00

abstract：:The purpose of tumour staging for colorectal cancer (CRC) is to help define clinical management, facilitate communication between physicians, provide a basis for stratification and analysis of treatment results in prospective studies, and provide some prognostic information for patients and their families. The World C...

journal_title：Journal of gastroenterology and hepatology

authors： Fielding LP,Arsenault PA,Chapuis PH,Dent O,Gathright B,Hardcastle JD,Hermanek P,Jass JR,Newland RC

更新日期：1991-07-01 00:00:00