Abstract:
:Human polyclonal immunoglobulin (Ig) G was attached to a monocrystalline iron oxide nanocompound (MION), a small superparamagnetic probe developed for receptor and antibody magnetic resonance (MR) imaging. The resulting complex, MION-IgG, had a slightly negative surface charge, a molecular weight of 150-180 kDa, and 0.36 microgram of IgG attached per milligram of iron. After intravenous administration of MION-IgG to normal rats, most of the compound localized in liver, spleen, and bone marrow. In an animal model of myositis, MION-IgG caused reduced signal intensity (most apparent on T2-weighted spin-echo and gradient-echo images) at the site of inflammation. No change in signal intensity existed after an injection of unlabeled MION. Site-specific localization of MION-IgG was corroborated with scintigraphic imaging with indium-111 IgG and MION-In-111-IgG and was confirmed histologically with iron staining. These results indicate that antibody MR imaging is feasible in vivo. Target-specific and antibody MR imaging could be easily extended to other applications, including detection of cancer, infarction, and degenerative diseases.
journal_name
Radiologyjournal_title
Radiologyauthors
Weissleder R,Lee AS,Fischman AJ,Reimer P,Shen T,Wilkinson R,Callahan RJ,Brady TJdoi
10.1148/radiology.181.1.1887040subject
Has Abstractpub_date
1991-10-01 00:00:00pages
245-9issue
1eissn
0033-8419issn
1527-1315journal_volume
181pub_type
杂志文章相关文献
RADIOLOGY文献大全abstract:PURPOSE:To determine whether liver tumor detection is increased by acquiring multiple dynamic arterial phase and portal venous phase magnetic resonance (MR) images. MATERIALS AND METHODS:Dynamic MR imaging was performed in 205 patients at 1.5 T with use of a fast spoiled gradient-echo technique (repetition time, 9-12 ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.201.2.8888220
更新日期:1996-11-01 00:00:00
abstract:PURPOSE:To characterize the imaging features of desmoplastic small round cell tumor of the abdomen and correlate them with the histopathologic findings. MATERIALS AND METHODS:Eleven of 14 patients with desmoplastic small round cell tumor had primary abdominal involvement. In nine of these patients (mean age, 20 years)...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.210.3.r99mr42633
更新日期:1999-03-01 00:00:00
abstract::Innovations in design of a dedicated breast scanner resulted in automation of the scanning process, the production of high resolution images of the whole breast and an efficient mode of image review. The results of clinical evaluation of the prototype of this breast scanner investigating normal breasts as well as beni...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.137.2.6254110
更新日期:1980-11-01 00:00:00
abstract::The magnetic resonance (MR) examinations of 18 patients with dilated bile ducts were reviewed retrospectively to determine the capability of MR to demonstrate biliary dilatation, assess MR appearance of the dilated biliary tract using spin-echo techniques, and define the optimal MR imaging parameters (repetition time ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.158.2.3941860
更新日期:1986-02-01 00:00:00
abstract:PURPOSE:To evaluate fluorine 18 ((18)F) dihydroxyphenylalanine (DOPA) whole-body positron emission tomography (PET) as a biochemical imaging approach for detection of pheochromocytomas. MATERIALS AND METHODS:(18)F DOPA PET and magnetic resonance (MR) imaging were performed in 14 consecutive patients suspected of havin...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2222010622
更新日期:2002-02-01 00:00:00
abstract::Purpose To retrospectively evaluate whether thermal injury-induced hepatic parenchymal hypoperfusion can be a significant risk factor for tumor recurrence after radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC). Materials and Methods The institutional review board approved this retrospective study, and t...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2016152322
更新日期:2017-03-01 00:00:00
abstract::The diagnostic quality and side effects of Amipaque and Pantopaque as myelographic contrast agents were compared prospectively using the identical protocol in 167 cases (117 Amipaque, 50 Pantopaque). Good ratings were attained in 74% of Amipaque and 76% of Pantopaque examinations. Demonstration of nerve rootlets in th...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/129.3.695
更新日期:1978-12-01 00:00:00
abstract::Liposomal gadolinium diethylenetriaminepentaacetic acid (DTPA) encapsulated within 70- and 400-nm vesicles was tested as a contrast agent for magnetic resonance (MR) imaging of the liver in rats with hepatic metastases. Liposomal Gd-DTPA caused significant improvement in contrast between liver and tumor (P less than ....
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.171.1.2928550
更新日期:1989-04-01 00:00:00
abstract::The authors evaluated the safety and efficacy of a biopsy gun for performance of image-guided percutaneous biopsy of hepatic allografts in liver transplant recipients. Two hundred fifty-two liver biopsies were performed in 58 transplant recipients over a 27-month period by using this instrument with an 18-gauge needle...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.179.2.2014290
更新日期:1991-05-01 00:00:00
abstract:PURPOSE:To evaluate the diagnostic potential of apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM)-derived parameters for differentiation of common pancreatic tumors, chronic pancreatitis, and normal pancreas and for characterization of the malignancy potential of intraductal papillary mucinou...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.13122712
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:To compare the stress experienced by women who had false-positive screening mammograms and had undergone immediate on-site diagnostic imaging evaluation with that experienced by those who had been recalled for subsequent imaging. MATERIALS AND METHODS:A retrospective survey was mailed to women with false-posit...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.218.1.r01ja35247
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:To describe the gray-scale and color and duplex Doppler ultrasound (US) and the magnetic resonance (MR) imaging features of uterine arteriovenous malformations (AVMs). MATERIALS AND METHODS:Uterine AVMs in 10 patients were retrospectively evaluated. All patients underwent gray-scale US and color and duplex Dop...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.206.1.9423660
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:To investigate whether default mode network (DMN) spatial properties can be directly affected by pain, with a comparison of painful and nonpainful conditions. MATERIALS AND METHODS:The authors performed a functional magnetic resonance (MR) imaging study, approved by the local institutional ethics committee, in...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2533090602
更新日期:2009-12-01 00:00:00
abstract::Although magnetic resonance (MR) imaging has been used to evaluate many musculoskeletal lesions, the MR appearance of pigmented villonodular synovitis (PVNS) has not been described in detail. The authors describe two cases of PVNS in the knee imaged with both computed tomography and MR. In both cases parts of each les...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.163.2.3562840
更新日期:1987-05-01 00:00:00
abstract:PURPOSE:To prospectively investigate steady-state blood volume measurements for early quantitative monitoring of antiangiogenic treatment with ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance (MR) imaging. MATERIALS AND METHODS:The institutional animal care committee approved all experiments...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2442060371
更新日期:2007-08-01 00:00:00
abstract:PURPOSE:To evaluate by using in vivo magnetic resonance (MR) imaging the functionality of a liposomal paramagnetic contrast agent with T1 relaxivity that rapidly and markedly increases at temperatures above the gel-to-liquid crystalline phase transition temperature (T(c)) of the liposome membrane. MATERIALS AND METHOD...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2303021713
更新日期:2004-03-01 00:00:00
abstract:PURPOSE:To determine the feasibility of measuring choline and glycogen concentrations in normal human liver in vivo with proton (hydrogen 1 [1H]) magnetic resonance (MR) spectroscopy. MATERIALS AND METHODS:Signed consent to participate in an institutional review board-approved and HIPAA-compliant study was obtained fr...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.12112344
更新日期:2012-11-01 00:00:00
abstract::The postnatal outcome of nine patients with the prenatal diagnosis of fetal hydronephrosis is reported. In only three of the nine cases was true obstructive hydronephrosis demonstrated, and in only one of these cases (11%) the patient might have benefited from decompressive surgery at the time of diagnosis of the abno...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.147.1.6828770
更新日期:1983-04-01 00:00:00
abstract:PURPOSE:To measure and elucidate the mechanisms of presumed mediators of unexpected severe, immediate reactions to iodinated contrast materials. MATERIALS AND METHODS:In a multicenter study, 20 patients with mild to severe reactions to iodinated contrast material and 20 control subjects without reactions were evaluate...
journal_title:Radiology
pub_type: 杂志文章,多中心研究
doi:10.1148/radiology.209.1.9769830
更新日期:1998-10-01 00:00:00
abstract:PURPOSE:To prospectively compare the accuracy of imaging with technetium-99m-labeled Fab' fragment of the anti-carcinoembryonic antigen antibody (CEA) IMMU-4 with that of computed tomography (CT) for the detection of pelvic recurrence of colorectal carcinoma. MATERIALS AND METHODS:In 61 patients, blinded interpretatio...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.197.3.7480740
更新日期:1995-12-01 00:00:00
abstract:PURPOSE:To assess the effectiveness of definitive radiation therapy in patients with superficial esophageal cancer. MATERIALS AND METHODS:Method of irradiation, local control rate, survival rate, and complications were assessed in 105 patients (89 men, 16 women; age range, 50-88 years) with superficial esophageal canc...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.196.1.7784580
更新日期:1995-07-01 00:00:00
abstract::Positron emission tomography (PET) with fluorine-18 fluoro-2-deoxy-D-glucose (FDG) was performed in 19 patients referred for clinical evaluation of soft-tissue masses. These patients had 20 different lesions and had been evaluated previously with computed tomography (CT) and/or magnetic resonance (MR) imaging. The dia...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.182.1.1727280
更新日期:1992-01-01 00:00:00
abstract::Radiographs of 18 children thought to have carbonic anhydrase II deficiency were reviewed to assess intracranial calcification. These children have an autosomal recessive syndrome consisting of osteopetrosis, renal tubular acidosis, intracranial calcification, and developmental retardation. This calcification is in th...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.157.2.2413500
更新日期:1985-11-01 00:00:00
abstract:PURPOSE:To compare the magnetic resonance (MR) imaging findings of primary hepatocellular carcinoma (HCC) in cirrhotic versus noncirrhotic livers. MATERIALS AND METHODS:MR images in 36 patients with HCC (30 men and she women aged 42-84 years [mean age, 65 years]) were retrospectively reviewed. The number and size of h...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.210.1.r99ja1975
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:To determine whether polytetrafluoroethylene (PTFE) stent-grafts yield longer patency for creation or revision of transjugular intrahepatic portosystemic shunts (TIPS). MATERIALS AND METHODS:Fourteen PTFE-covered Wallstents were placed in 13 patients with TIPS: seven at shunt creation and seven during revision...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.213.3.r99dc28759
更新日期:1999-12-01 00:00:00
abstract:PURPOSE:To perform and assess the effectiveness of local excision of recurrent tumor followed by postoperative pulse dose rate (PDR) brachytherapy. MATERIALS AND METHODS:From 1994 to 2000, 17 patients who had small recurrent breast carcinomas after initially undergoing breast-conserving therapy (BCT), which included p...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2253011913
更新日期:2002-12-01 00:00:00
abstract::High-resolution real-time ultrasound with either a 7.5- or 10-MHz transducer was used to localize 7/9 nonpalpable breast masses previously detected by mammography and to determine where the biopsy needle should be inserted. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.151.3.6718740
更新日期:1984-06-01 00:00:00
abstract::Fifty-one pediatric patients (range, 1 mo. to 16 yr.), all of whom had normal clinical findings and laboratory data pertaining to the gallbladder and biliary tract, were examined by ultrasound. Scans showed a gradual increase in the size of the gallbladder with age; only one patient had a gallbladder diameter greater ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.144.4.7111740
更新日期:1982-09-01 00:00:00
abstract::Sonographic analysis of the sciatic nerve was performed in vitro (anatomic specimen), in vivo (healthy volunteers), and in 16 patients with suspected peripheral sciatic nerve lesions. The ultrasound (US) examinations were performed with standard and high-resolution US equipment with linear-array configuration. The nor...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.181.2.1924780
更新日期:1991-11-01 00:00:00
abstract:PURPOSE:To investigate the challenges and benefits of magnetic resonance (MR) imaging during brain tumor resection. MATERIALS AND METHODS:A short-bore 1.5-T MR system equipped with echo-planar-capable gradients was used in resection of brain tumors in 30 patients. MR sequences and need for contrast material enhancemen...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.215.1.r00ap31221
更新日期:2000-04-01 00:00:00