Abstract:
:Liposomal gadolinium diethylenetriaminepentaacetic acid (DTPA) encapsulated within 70- and 400-nm vesicles was tested as a contrast agent for magnetic resonance (MR) imaging of the liver in rats with hepatic metastases. Liposomal Gd-DTPA caused significant improvement in contrast between liver and tumor (P less than .005) on T1-weighted MR images. Smaller 70-nm liposomal Gd-DTPA vesicles caused greater contrast enhancement, reflecting the larger surface-area-to-volume ratio of the smaller vesicles. Liposomal Gd-DTPA-enhanced images permitted significant improvement in metastasis detection by five blinded radiologists (P less than .005). By comparison, free Gd-DTPA without liposomes caused a statistically significant reduction in contrast between tumor and liver and reduced lesion detection (P less than .01). Liposomal Gd-DTPA also resulted in sustained vascular enhancement for 1 hour after administration. The results suggest that paramagnetic liposomes may become a useful MR imaging contrast agent.
journal_name
Radiologyjournal_title
Radiologyauthors
Unger EC,Winokur T,MacDougall P,Rosenblum J,Clair M,Gatenby R,Tilcock Cdoi
10.1148/radiology.171.1.2928550subject
Has Abstractpub_date
1989-04-01 00:00:00pages
81-5issue
1eissn
0033-8419issn
1527-1315journal_volume
171pub_type
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