Antiangiogenic tumor treatment: early noninvasive monitoring with USPIO-enhanced MR imaging in mice.

Abstract:

PURPOSE:To prospectively investigate steady-state blood volume measurements for early quantitative monitoring of antiangiogenic treatment with ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance (MR) imaging. MATERIALS AND METHODS:The institutional animal care committee approved all experiments. HT-1080 fibrosarcoma-bearing nude mice were injected with a thrombogenic vascular targeting agent (VTA) (11 nude mice, 20 tumors) or saline (12 nude mice, 20 tumors). USPIO-enhanced (SH U 555C) MR imaging was performed after the VTA was administered. USPIO-induced changes in tissue R2* (DeltaR2*) were measured with a T2-weighted dual-echo echo-planar imaging sequence, and the vascular volume fraction (VVF) was calculated. Parametric DeltaR2* maps were analyzed with respect to tumor perfusion patterns. Correlative histologic analysis was performed for grading of tissue thrombosis, and tissue perfusion was quantified with fluorescent microbeads. Unpaired Student t test and Spearman nonparametric correlation coefficient were used for statistical analysis. RESULTS:The DeltaR2* values were significantly (P < .001) reduced shortly after treatment initiation (mean DeltaR2*, 0.017 msec(-1) +/- 0.0014 [standard error] in control animals vs 0.005 msec(-1) +/- 0.0007 in animals that received VTA), which was also reflected by a decrease in the VVF (2.47% +/- 0.18 vs 0.41% +/- 0.48, P < .001). Histologic analysis revealed various degrees of tumor thrombosis after VTA treatment that correlated inversely with the DeltaR2* values (r = -0.83). Moreover, tumor perfusion measurements corroborated the MR results, indicating a significant reduction in tissue perfusion after VTA treatment (mean tissue fluorescence, 570.4 arbitrary units [au] per gram +/- 27 vs 161.7 au/g +/- 17; P < .05). CONCLUSION:USPIO-enhanced MR imaging enables early monitoring of antiangiogenic treatment of tumors.

journal_name

Radiology

journal_title

Radiology

authors

Persigehl T,Bieker R,Matuszewski L,Wall A,Kessler T,Kooijman H,Meier N,Ebert W,Berdel WE,Heindel W,Mesters RM,Bremer C

doi

10.1148/radiol.2442060371

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

449-56

issue

2

eissn

0033-8419

issn

1527-1315

pii

2442060371

journal_volume

244

pub_type

杂志文章
  • Cervical carcinoma: MR imaging with an endorectal surface coil.

    abstract::Ten consecutive patients with biopsy-proved invasive cervical carcinoma underwent magnetic resonance (MR) imaging with both a standard body coil and with an endorectal surface coil. The endorectal coil provided a markedly improved signal-to-noise ratio, enabling the use of small fields of view; thus, the images had si...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.180.1.2052730

    authors: Milestone BN,Schnall MD,Lenkinski RE,Kressel HY

    更新日期:1991-07-01 00:00:00

  • Splenic enlargement in neonates during ECMO.

    abstract:PURPOSE:To determine whether hepatosplenomegaly was a reproducible finding in seven neonates who were being treated with extracorporeal membrane oxygenation (ECMO) for respiratory failure. MATERIALS AND METHODS:The authors measured splenic and hepatic dimensions with ultrasound (US) at the time ECMO was initiated and ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.190.2.8284390

    authors: Klippenstein DL,Zerin JM,Hirschl RB,Donn SM

    更新日期:1994-02-01 00:00:00

  • Diagnostic ultrasound: effects on the DNA and growth patterns of animal cells.

    abstract::The effects of diagnostic levels of ultrasound on DNA of HeLa cells included: increased immunoreactivity to antinucleoside antibodies in G1 cells, strongly suggestive of unwinding of the helix or single-strand break induction, and low levels of non-semiconservative synthesis in logarithmically growing cells treated wi...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/131.1.177

    authors: Liebeskind D,Bases R,Elequin F,Neubort S,Leifer R,Goldberg R,Koenigsberg M

    更新日期:1979-04-01 00:00:00

  • Kidney function: glomerular filtration rate measurement with MR renography in patients with cirrhosis.

    abstract:PURPOSE:To assess the accuracy of glomerular filtration rate (GFR) measurements obtained with low-contrast agent dose dynamic contrast material-enhanced magnetic resonance (MR) renography in patients with liver cirrhosis who underwent routine liver MR imaging, with urinary clearance of technetium 99m ((99m)Tc) pentetic...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.11101338

    authors: Vivier PH,Storey P,Rusinek H,Zhang JL,Yamamoto A,Tantillo K,Khan U,Lim RP,Babb JS,John D,Teperman LW,Chandarana H,Friedman K,Benstein JA,Skolnik EY,Lee VS

    更新日期:2011-05-01 00:00:00

  • Timeliness of follow-up after abnormal screening mammogram: variability of facilities.

    abstract:PURPOSE:To describe the timeliness of follow-up care in community-based settings among women who receive a recommendation for immediate follow-up during the screening mammography process and how follow-up timeliness varies according to facility and facility-level characteristics. MATERIALS AND METHODS:This was an inst...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.11102472

    authors: Rosenberg RD,Haneuse SJ,Geller BM,Buist DS,Miglioretti DL,Brenner RJ,Smith-Bindman R,Taplin SH,Breast Cancer Surveillance Consortium.

    更新日期:2011-11-01 00:00:00

  • Thalamic resting-state functional networks: disruption in patients with mild traumatic brain injury.

    abstract:PURPOSE:To explore the neural correlates of the thalamus by using resting-state functional magnetic resonance (MR) imaging and to investigate whether thalamic resting-state networks (RSNs) are disrupted in patients with mild traumatic brain injury (MTBI). MATERIALS AND METHODS:This HIPAA-compliant study was approved b...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.11110014

    authors: Tang L,Ge Y,Sodickson DK,Miles L,Zhou Y,Reaume J,Grossman RI

    更新日期:2011-09-01 00:00:00

  • Liver metastases in candidates for hepatic resection: comparison of helical CT and gadolinium- and SPIO-enhanced MR imaging.

    abstract:PURPOSE:To prospectively compare accuracy of dynamic contrast material-enhanced thin-section multi-detector row helical computed tomography (CT), high-spatial-resolution three-dimensional (3D) dynamic gadolinium-enhanced magnetic resonance (MR) imaging, and superparamagnetic iron oxide (SPIO)-enhanced MR imaging with o...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2371041444

    authors: Ward J,Robinson PJ,Guthrie JA,Downing S,Wilson D,Lodge JP,Prasad KR,Toogood GJ,Wyatt JI

    更新日期:2005-10-01 00:00:00

  • Bronchiolitis obliterans syndrome: thin-section CT diagnosis of obstructive changes in infants and young children after lung transplantation.

    abstract:PURPOSE:To characterize the thin-section computed tomographic (CT) appearance of bronchiolitis fibrosa obliterans syndrome in infants and young children after lung transplantation. MATERIALS AND METHODS:Thin-section CT studies in six patients with bronchiolitis obliterans syndrome (age range, 2 months to 5 1/2 years) ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.208.3.9722860

    authors: Lau DM,Siegel MJ,Hildebolt CF,Cohen AH

    更新日期:1998-09-01 00:00:00

  • Radionuclide bone imaging in the early detection of fractures of the proximal femur (hip): multifactorial analysis.

    abstract::The results of 179 radionuclide bone imaging examinations, 105 gathered retrospectively from the cases of 97 patients referred for assessment of possible occult fracture of the proximal femur (hip) and 74 performed prospectively on 63 patients referred with a diagnosis of obvious or suspected hip fracture, were analyz...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.174.2.2404320

    authors: Holder LE,Schwarz C,Wernicke PG,Michael RH

    更新日期:1990-02-01 00:00:00

  • Coronary artery disease: assessment with a comprehensive MR imaging protocol--initial results.

    abstract::A comprehensive magnetic resonance (MR) imaging protocol for assessment of coronary artery disease (CAD) is presented. The protocol includes multiphase gradient-echo cine MR imaging for assessment of cardiac function, first-pass myocardial perfusion imaging at rest and during adenosine stress, MR imaging with delayed ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2243011436

    authors: Plein S,Ridgway JP,Jones TR,Bloomer TN,Sivananthan MU

    更新日期:2002-10-01 00:00:00

  • The power button sign: a newly described central sulcal pattern on surface rendering MR images of type 2 focal cortical dysplasia.

    abstract:PURPOSE:To compare the occurrence of several central sulcus variants and to assess the reproducibility of a sulcal pattern named the power button sign (PBS) in patients with type 2 focal cortical dysplasia (FCD2) and healthy control subjects. MATERIALS AND METHODS:The local institutional review board approved the stud...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.14140773

    authors: Mellerio C,Roca P,Chassoux F,Danière F,Cachia A,Lion S,Naggara O,Devaux B,Meder JF,Oppenheim C

    更新日期:2015-02-01 00:00:00

  • Hyperparathyroidism in high-risk surgical patients: evaluation with double-phase technetium-99m sestamibi imaging.

    abstract:PURPOSE:To evaluate the accuracy of technetium-99m sestamibi as a single agent in the detection and localization of hyperfunctioning parathyroid tissue in patients who underwent prior neck exploration or who otherwise are high surgical risks. MATERIALS AND METHODS:Thirty-nine patients with hyperparathyroidism underwen...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.197.3.7480730

    authors: Lee VS,Wilkinson RH Jr,Leight GS Jr,Coogan AC,Coleman RE

    更新日期:1995-12-01 00:00:00

  • Ultrasonography of peritoneal tumors.

    abstract::Peritoneal masses arising from different types of primary carcinoma were studied ultrasonographically in 34 patients as well as with computed tomography in 3 patients. In shape, the masses were nodular, mantle- or sheetlike, or irregular. The peritoneal line was usually obliterated unless the mass was very small. When...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/133.2.419

    authors: Yeh HC

    更新日期:1979-11-01 00:00:00

  • A radiographic study of the ligamentous anatomy of the ankle.

    abstract::Ankle trauma commonly results in significant injury. Knowledge of the anatomy of the normally nonopaque major supportive ligaments, and their relationships to the osseous structures seen on standard roentgenograms, facilitates interpretation of both plain films and ankle arthrograms. A group of normal, non-preserved a...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/125.3.659

    authors: Kaye JJ,Bohne WH

    更新日期:1977-12-01 00:00:00

  • Combined therapy of osteosarcoma: preoperative irradiation, surgery, and chemotherapy.

    abstract::The rationale for prebiopsy and preoperative irradiation in a multimodal approach to treatment of osteosarcoma is presented. Six patients with osteosarcoma underwent preoperative irradiation, amputation, and elective chemotherapy. Five of these also received prebiopsy irradiation: three survive without metastases at 2...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/125.2.497

    authors: Munzenrider JE,Emami B,Tchakarova I,Necheles TF,Banks HH,Paradelo JC,Oh WH

    更新日期:1977-11-01 00:00:00

  • Esophageal varices: noninvasive diagnosis with duplex Doppler US in patients with compensated cirrhosis.

    abstract:PURPOSE:To prospectively develop and evaluate the accuracy of a duplex Doppler ultrasonographic (US) index for predicting the presence or absence of esophageal varices in patients with compensated cirrhosis (Child-Pugh class A) by using endoscopy as the reference standard. MATERIALS AND METHODS:The study had instituti...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2481071257

    authors: Liu CH,Hsu SJ,Liang CC,Tsai FC,Lin JW,Liu CJ,Yang PM,Lai MY,Chen PJ,Chen JH,Kao JH,Chen DS

    更新日期:2008-07-01 00:00:00

  • The choice of sedation for computed tomography in children: a prospective evaluation.

    abstract::A prospective study of 582 pediatric cranial computed tomographic (CT) examinations was made in order to determine the efficacy and safety of two sedation regimens and general anesthesia. Two hundred seventy-nine outpatients were randomly given oral chloral hydrate (80 mg/kg) or an intramuscular preparation composed o...

    journal_title:Radiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1148/radiology.143.2.7071350

    authors: Thompson JR,Schneider S,Ashwal S,Holden BS,Hinshaw DB Jr,Hasso AN

    更新日期:1982-05-01 00:00:00

  • Vertebral bone marrow perfusion evaluated with dynamic contrast-enhanced MR imaging: significance of aging and sex.

    abstract:PURPOSE:To investigate blood perfusion of nonfractured, normal-appearing vertebral bodies with regard to age and sex. MATERIALS AND METHODS:Dynamic magnetic resonance imaging (160 images obtained in 80 seconds) was performed from T10 to L5 in 66 patients. Patients were assigned to three groups: group 1, those 50 years...

    journal_title:Radiology

    pub_type: 临床试验,杂志文章

    doi:10.1148/radiology.220.1.r01jl32213

    authors: Chen WT,Shih TT,Chen RC,Lo SY,Chou CT,Lee JM,Tu HY

    更新日期:2001-07-01 00:00:00

  • Thermography, mammography, and clinical examination in breast cancer screening. Review of 16,000 studies.

    abstract::Breast cancer screening detected 139 biopsy-proved malignancies in 16,000 slef-selected women (8.7/1,000). In these, xeroradiography detected 78% (109), clinical examination 55% (76), and thermography 39% (54). In all 16,000 women, the thermogram was interpreted as positive in 17.9% (2,864). The greatest effectiveness...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/122.1.123

    authors: Feig SA,Shaber GS,Schwartz GF,Patchefsky A,Libshitz HI,Edeiken J,Nerlinger R,Curley RF,Wallace JD

    更新日期:1977-01-01 00:00:00

  • Reflex sympathetic dystrophy in the foot: clinical and scintigraphic criteria.

    abstract::To establish strict clinical criteria for reflex sympathetic dystrophy (RSD) of the foot and to characterize any associated scintigraphic pattern, the authors performed three-phase radionuclide bone scanning in 51 patients prospectively referred because RSD was a diagnostic consideration. To establish sensitivity and ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.184.2.1620860

    authors: Holder LE,Cole LA,Myerson MS

    更新日期:1992-08-01 00:00:00

  • Carotid angioplasty and stent placement: comparison of transcranial Doppler US data and clinical outcome with and without filtering cerebral protection devices in 509 patients.

    abstract:PURPOSE:To prospectively evaluate emboli detected at transcranial Doppler ultrasonography (US) and outcome of carotid angioplasty and stent placement and compare these findings in patients treated with the use of filtering cerebral protection devices (CPDs) with the findings in patients treated without the use of filte...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2342040119

    authors: Vos JA,van den Berg JC,Ernst SM,Suttorp MJ,Overtoom TT,Mauser HW,Vogels OJ,van Heesewijk HP,Moll FL,van der Graaf Y,Mali WP,Ackerstaff RG

    更新日期:2005-02-01 00:00:00

  • Ultrasonic evaluation of intracranial pathology in infants: a new technique.

    abstract::A prospective study had demonstrated the clinical usefulness of water-delay ultrasound as a means of routinely imaging the intracranial contents in infants younger than one year of age. Correlation between ultrasound and CT images was excellent, showing both normal and pathological anatomy. This technique is most help...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.134.1.7350600

    authors: Haber K,Wachter RD,Christenson PC,Vaucher Y,Sahn DJ,Smith JR

    更新日期:1980-01-01 00:00:00

  • What the diagnostic radiologist needs to know about radiation oncology.

    abstract::Substantial technologic advances in radiation treatment planning and delivery have made possible exquisite tailoring of three-dimensional radiation dose distributions that conform to the tumor treatment volume while avoiding adjacent normal tissues. Although such highly precise treatment can increase the therapeutic r...

    journal_title:Radiology

    pub_type: 杂志文章,评审

    doi:10.1148/radiol.11101688

    authors: Terezakis SA,Heron DE,Lavigne RF,Diehn M,Loo BW Jr

    更新日期:2011-10-01 00:00:00

  • Pulmonary hypertrophic osteoarthropathy in cystic fibrosis.

    abstract::A survey was carried out in 40 patients with cystic fibrosis to determine how many of them showed evidence of pulmonary hypertrophic osteoarthropathy (PHOA) and whether pulmonary function abnormalities, sputum cultures, or a history of joint or bone symptoms could be used to aid in its diagnosis. This survey indicates...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.135.3.7384450

    authors: Nathanson I,Riddlesberger MM Jr

    更新日期:1980-06-01 00:00:00

  • US Molecular Imaging of Acute Ileitis: Anti-Inflammatory Treatment Response Monitored with Targeted Microbubbles in a Preclinical Model.

    abstract::Purpose To evaluate whether dual-selectin-targeted US molecular imaging allows longitudinal monitoring of anti-inflammatory treatment effects in an acute terminal ileitis model in swine. Materials and Methods The Institutional Animal Care and Use Committee approved all animal studies. Fourteen swine with chemically in...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2018172600

    authors: Wang H,Hyvelin JM,Felt SA,Guracar I,Vilches-Moure JG,Cherkaoui S,Bettinger T,Tian L,Lutz AM,Willmann JK

    更新日期:2018-10-01 00:00:00

  • Contrast agents lower ventricular fibrillation threshold.

    abstract::Ventricular fibrillation thresholds were measured in anesthetized, closed-chest dogs during the injection of Renografin 76 or Conray 400 into the left coronary artery. Both agents significantly lowered fibrillation threshold--Renografin to 58 +/- 7%; Conray to 20 +/- 5% of control, respectively. The experimental metho...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/129.1.215

    authors: Wolf GL,Kraft L,Kilzer K

    更新日期:1978-10-01 00:00:00

  • In-plane coronary arterial motion velocity: measurement with electron-beam CT.

    abstract:PURPOSE:To determine the speed of and changes in the speed of coronary arterial movement during the cardiac cycle with electron-beam computed tomography (CT). MATERIALS AND METHODS:With electron-beam CT, 20 consecutive cross-sectional images were acquired at the mid right coronary artery (with 50-msec acquisition time...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.216.2.r00au19457

    authors: Achenbach S,Ropers D,Holle J,Muschiol G,Daniel WG,Moshage W

    更新日期:2000-08-01 00:00:00

  • Screening for early lung cancer with low-dose spiral CT: prevalence in 817 asymptomatic smokers.

    abstract:PURPOSE:To present prevalence screening data from a nonrandomized screening trial by using low-dose computed tomography (CT) and a simple algorithm based on the size and attenuation of detected nodules to guide diagnostic work-up. MATERIALS AND METHODS:Eight hundred seventeen asymptomatic volunteers (age range, 40-78 ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2223010490

    authors: Diederich S,Wormanns D,Semik M,Thomas M,Lenzen H,Roos N,Heindel W

    更新日期:2002-03-01 00:00:00

  • Early-stage hepatocellular carcinoma: radiofrequency ablation combined with chemoembolization versus hepatectomy.

    abstract:PURPOSE:To retrospectively evaluate the long-term results of radiofrequency (RF) ablation combined with chemoembolization (combination therapy) as compared with hepatectomy for the treatment of early-stage hepatocellular carcinoma (HCC). MATERIALS AND METHODS:The study was approved by the institutional review board, a...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2471070818

    authors: Yamakado K,Nakatsuka A,Takaki H,Yokoi H,Usui M,Sakurai H,Isaji S,Shiraki K,Fuke H,Uemoto S,Takeda K

    更新日期:2008-04-01 00:00:00

  • Craniosynostosis: diagnostic value of three-dimensional CT reconstruction.

    abstract::Three-dimensional computed tomography (CT) has an important role in determining the presence and extent of congenital and acquired craniofacial deformities. The authors compared the sensitivity and specificity of three-dimensional CT in the detection and characterization of craniosynostosis with that of planar CT and ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.173.3.2813770

    authors: Vannier MW,Hildebolt CF,Marsh JL,Pilgram TK,McAlister WH,Shackelford GD,Offutt CJ,Knapp RH

    更新日期:1989-12-01 00:00:00