Mechanisms of severe, immediate reactions to iodinated contrast material.

Abstract:

PURPOSE:To measure and elucidate the mechanisms of presumed mediators of unexpected severe, immediate reactions to iodinated contrast materials. MATERIALS AND METHODS:In a multicenter study, 20 patients with mild to severe reactions to iodinated contrast material and 20 control subjects without reactions were evaluated. Ionic contrast material was associated with 18 (90%) of 20 reactions. Concentrations of plasma histamine, tryptase, urinary methylhistamine, specific immunoglobulin E (IgE) against ioxitalamate or ioxaglate, and the anaphylatoxins C3a and C4a were measured with radioimmunoassays; complement C3 and C4 levels were measured with nephelometry. RESULTS:Histamine levels were increased in 14 patients; tryptase levels, in 16; and methylhistamine levels, in six. Histamine and tryptase values correlated with the severity of the reaction (P < .02 and P < .004, respectively). Significantly higher levels of specific IgE against ioxaglate (P < .005) and ioxitalamate (P = .045) were found in patients. No differences were found for complement fractions. Skin test results in two patients with life-threatening reactions were positive for the administered contrast material. CONCLUSION:Histamine release and mast cell triggering are related to severe reactions. An IgE-related mechanism is strongly suspected. Radiologists should be trained to identify and treat anaphylactic shock in patients who react to iodinated contrast material.

journal_name

Radiology

journal_title

Radiology

authors

Laroche D,Aimone-Gastin I,Dubois F,Huet H,Gérard P,Vergnaud MC,Mouton-Faivre C,Guéant JL,Laxenaire MC,Bricard H

doi

10.1148/radiology.209.1.9769830

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

183-90

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

209

pub_type

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