Breast tissue characterization with photon-counting spectral CT imaging: a postmortem breast study.

Abstract:

PURPOSE:To investigate the feasibility of breast tissue characterization in terms of water, lipid, and protein contents with a spectral computed tomographic (CT) system based on a cadmium zinc telluride (CZT) photon-counting detector by using postmortem breasts. MATERIALS AND METHODS:Nineteen pairs of postmortem breasts were imaged with a CZT-based photon-counting spectral CT system with beam energy of 100 kVp. The mean glandular dose was estimated to be in the range of 1.8-2.2 mGy. The images were corrected for pulse pile-up and other artifacts by using spectral distortion corrections. Dual-energy decomposition was then applied to characterize each breast into water, lipid, and protein contents. The precision of the three-compartment characterization was evaluated by comparing the composition of right and left breasts, where the standard error of the estimations was determined. The results of dual-energy decomposition were compared by using averaged root mean square to chemical analysis, which was used as the reference standard. RESULTS:The standard errors of the estimations of the right-left correlations obtained from spectral CT were 7.4%, 6.7%, and 3.2% for water, lipid, and protein contents, respectively. Compared with the reference standard, the average root mean square error in breast tissue composition was 2.8%. CONCLUSION:Spectral CT can be used to accurately quantify the water, lipid, and protein contents in breast tissue in a laboratory study by using postmortem specimens.

journal_name

Radiology

journal_title

Radiology

authors

Ding H,Klopfer MJ,Ducote JL,Masaki F,Molloi S

doi

10.1148/radiol.14132732

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

731-8

issue

3

eissn

0033-8419

issn

1527-1315

journal_volume

272

pub_type

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