Abstract：
INTRODUCTION:Positron emission tomography (PET) is a fully quantitative technology for imaging metabolic pathways and dynamic processes in vivo. Attenuation correction of raw PET data is a prerequisite for quantification and is typically based on separate transmission measurements. In PET/CT attenuation correction, however, is performed routinely based on the available CT transmission data. OBJECTIVE:Recently, combined PET/magnetic resonance (MR) has been proposed as a viable alternative to PET/CT. Current concepts of PET/MRI do not include CT-like transmission sources and, therefore, alternative methods of PET attenuation correction must be found. This article reviews existing approaches to MR-based attenuation correction (MR-AC). Most groups have proposed MR-AC algorithms for brain PET studies and more recently also for torso PET/MR imaging. Most MR-AC strategies require the use of complementary MR and transmission images, or morphology templates generated from transmission images. We review and discuss these algorithms and point out challenges for using MR-AC in clinical routine. DISCUSSION:MR-AC is work-in-progress with potentially promising results from a template-based approach applicable to both brain and torso imaging. While efforts are ongoing in making clinically viable MR-AC fully automatic, further studies are required to realize the potential benefits of MR-based motion compensation and partial volume correction of the PET data.
journal_name
Eur J Nucl Med Mol Imagingauthors
Hofmann M,Pichler B,Schölkopf B,Beyer Tdoi
10.1007/s00259-008-1007-7subject
Has Abstractpub_date
2009-03-01 00:00:00pages
S93-104eissn
1619-7070issn
1619-7089journal_volume
36 Suppl 1pub_type
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
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