Chronic thyroiditis in patients with advanced breast carcinoma: metabolic and morphologic changes on PET-CT.

Abstract:

PURPOSE:To investigate clinical implications of FDG uptake in the thyroid glands in patients with advanced breast carcinoma by comparing metabolic and morphologic patterns on positron emission tomography (PET)/computed tomography (CT). METHODS:The institutional review board waived the requirement for informed consent. A retrospective analysis was performed in 146 women (mean age 54 years) with advanced breast carcinoma who received systemic treatment. All patients underwent PET-CT before and after treatment. All PET-CT studies were reviewed in consensus by two reviewers. Morphologic changes including volume and mean parenchymal density of the thyroid glands were evaluated. Maximum standardized uptake value (SUVmax) and total lesion glycolysis (TLG) were determined to evaluate metabolic changes. These parameters were compared between patients with chronic thyroiditis who received thyroid hormone replacement therapy and those who did not. RESULTS:Of the 146 patients, 29 (20%) showed bilaterally diffuse uptake in the thyroid glands on the baseline PET-CT scan. The SUVmax showed a linear relationship with volume (r = 0.428, p = 0.021) and the mean parenchymal density (r = -0.385, p = 0.039) of the thyroid glands. In 21 of the 29 patients (72%) with hypothyroidism who received thyroid hormone replacement therapy, the volume, mean parenchymal density, SUVmax, and TLG of the thyroid glands showed no significant changes. In contrast, 8 of the 29 patients (28%) who did not receive thyroid hormone replacement therapy showed marked decreases in SUVmax and TLG. CONCLUSION:Diffuse thyroid uptake on PET-CT represents active inflammation caused by chronic thyroiditis in patients with advanced breast carcinoma. Diffuse thyroid uptake may also address the concern about subclinical hypothyroidism which develops into overt disease during follow-up.

authors

Tateishi U,Gamez C,Dawood S,Yeung HW,Cristofanilli M,Inoue T,Macapinlac HA

doi

10.1007/s00259-008-1048-y

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

894-902

issue

6

eissn

1619-7070

issn

1619-7089

journal_volume

36

pub_type

杂志文章
  • 18F-fluorodeoxyglucose uptake of hepatocellular carcinoma as a prognostic predictor in patients with sorafenib treatment.

    abstract:PURPOSE:Sorafenib, an oral multikinase inhibitor, is a recommended treatment option available for patients with Barcelona Clinic Liver Cancer (BCLC)-C stage hepatocellular carcinoma (HCC). This study aimed to evaluate the performance of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) for predicting tu...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-017-3871-5

    authors: Sung PS,Park HL,Yang K,Hwang S,Song MJ,Jang JW,Choi JY,Yoon SK,Yoo IR,Bae SH

    更新日期:2018-03-01 00:00:00

  • PET/CT assessment in follicular lymphoma using standardized criteria: central review in the PRIMA study.

    abstract:PURPOSE:We aimed to compare the standardized central review of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT scans performed after induction therapy for follicular lymphoma (FL) in the PRIMA study (Salles et al., Lancet 377:42-51, 2011; Trotman et al., J Clin Oncol 29:3194-3200, 2011) to scan rev...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-013-2441-8

    authors: Tychyj-Pinel C,Ricard F,Fulham M,Fournier M,Meignan M,Lamy T,Vera P,Salles G,Trotman J

    更新日期:2014-03-01 00:00:00

  • Identification of advanced coronary artery disease with exercise myocardial perfusion imaging: the clinical value of a novel approach for assessing lung thallium-201 uptake.

    abstract:INTRODUCTION:The precise clinical utility of lung 201Tl uptake in exercise SPECT myocardial perfusion imaging remains open to research. This study validates an optimal index for lung 201Tl uptake measurement and assesses its value in the prediction of higher-risk coronary artery disease (CAD). METHOD:Three hundred and...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-006-0255-7

    authors: Moralidis E,Spyridonidis T,Arsos G,Anagnostopoulos C

    更新日期:2007-04-01 00:00:00

  • Clinical features and 123I-FP-CIT SPECT imaging in drug-induced parkinsonism and Parkinson's disease.

    abstract:PURPOSE:To determine clinical predictors and accuracy of (123)I-FP-CIT SPECT imaging in the differentiation of drug-induced parkinsonism (DIP) and Parkinson's disease (PD). METHODS:Several clinical features and (123)I-FP-CIT SPECT images in 32 patients with DIP, 25 patients with PD unmasked by antidopaminergic drugs (...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-009-1289-4

    authors: Diaz-Corrales FJ,Sanz-Viedma S,Garcia-Solis D,Escobar-Delgado T,Mir P

    更新日期:2010-03-01 00:00:00

  • Fully automatic diagnostic system for early- and late-onset mild Alzheimer's disease using FDG PET and 3D-SSP.

    abstract:PURPOSE:The purpose of this study was to design a fully automatic computer-assisted diagnostic system for early- and late-onset mild Alzheimer's disease (AD). METHODS:Glucose metabolic images were obtained from mild AD patients and normal controls using positron emission tomography (PET) and( 18)F-fluorodeoxyglucose (...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-005-0015-0

    authors: Ishii K,Kono AK,Sasaki H,Miyamoto N,Fukuda T,Sakamoto S,Mori E

    更新日期:2006-05-01 00:00:00

  • Radioembolisation in patients with hepatocellular carcinoma that have previously received liver-directed therapies.

    abstract:PURPOSE:Radioembolisation is part of the multimodal treatment of hepatocellular carcinoma (HCC) at specialist liver centres. This study analysed the impact of prior treatment on tolerability and survival following radioembolisation. METHODS:This was a retrospective analysis of 325 consecutive patients with a confirmed...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-018-3968-5

    authors: Sangro B,Maini CL,Ettorre GM,Cianni R,Golfieri R,Gasparini D,Ezziddin S,Paprottka PM,Fiore F,Van Buskirk M,Bilbao JI,Salvatori R,Giampalma E,Geatti O,Wilhelm K,Hoffmann RT,Izzo F,Iñarrairaegui M,Urigo C,Cappelli A,

    更新日期:2018-09-01 00:00:00

  • The impact of coaxial core biopsy guided by FDG PET/CT in oncological patients.

    abstract:OBJECTIVE:When deciding on therapy, FDG PET/CT-positive results should be confirmed by histology if possible. We evaluated the impact of percutaneous PET/CT-guided biopsies on histological confirmation of PET/CT-positive lesions. METHODS:We prospectively evaluated 126 patients who had undergone a PET/CT scan with posi...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-012-2263-0

    authors: Cerci JJ,Pereira Neto CC,Krauzer C,Sakamoto DG,Vitola JV

    更新日期:2013-01-01 00:00:00

  • 18F-Fluorodeoxyglucose positron emission tomography pulmonary imaging in idiopathic pulmonary fibrosis is reproducible: implications for future clinical trials.

    abstract:PURPOSE:Noninvasive markers of disease activity in patients with idiopathic pulmonary fibrosis (IPF) are lacking. We performed this study to investigate the reproducibility of pulmonary (18)F-FDG PET/CT in patients with IPF. METHODS:The study group comprised 13 patients (11 men, 2 women; mean age 71.1 ± 9.9 years) wit...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-011-1986-7

    authors: Win T,Lambrou T,Hutton BF,Kayani I,Screaton NJ,Porter JC,Maher TM,Endozo R,Shortman RI,Lukey P,Groves AM

    更新日期:2012-03-01 00:00:00

  • Effect of the positron range of 18F, 68Ga and 124I on PET/CT in lung-equivalent materials.

    abstract:PURPOSE:The aim of this study was to investigate the effect of positron range on visualization and quantification in (18)F, (68)Ga and (124)I positron emission tomography (PET)/CT of lung-like tissue. METHODS:Different sources were measured in air, in lung-equivalent foams and in water, using a clinical PET/CT and a m...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-011-1732-1

    authors: Kemerink GJ,Visser MG,Franssen R,Beijer E,Zamburlini M,Halders SG,Brans B,Mottaghy FM,Teule GJ

    更新日期:2011-05-01 00:00:00

  • Textural features of 18F-fluorodeoxyglucose positron emission tomography scanning in diagnosing aortic prosthetic graft infection.

    abstract:BACKGROUND:The clinical problem in suspected aortoiliac graft infection (AGI) is to obtain proof of infection. Although 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography scanning (PET) has been suggested to play a pivotal role, an evidence-based interpretation is lacking. The objective of this retrospective...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-016-3599-7

    authors: Saleem BR,Beukinga RJ,Boellaard R,Glaudemans AW,Reijnen MM,Zeebregts CJ,Slart RH

    更新日期:2017-05-01 00:00:00

  • Novel 111In-labelled bombesin analogues for molecular imaging of prostate tumours.

    abstract:PURPOSE:It has been shown that some primary human tumours and their metastases, including prostate and breast tumours, overexpress gastrin-releasing peptide (GRP) receptors. Bombesin (BN) is a neuropeptide with a high affinity for these GRP receptors. We demonstrated successful scintigraphic visualisation of BN recepto...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-006-0356-3

    authors: de Visser M,Bernard HF,Erion JL,Schmidt MA,Srinivasan A,Waser B,Reubi JC,Krenning EP,de Jong M

    更新日期:2007-08-01 00:00:00

  • Feasibility of multi-parametric PET and MRI for prediction of tumour recurrence in patients with glioblastoma.

    abstract:BACKGROUND:Recurrence in glioblastoma patients often occur close to the original tumour and indicates that the current treatment is inadequate for local tumour control. In this study, we explored the feasibility of using multi-modality imaging at the time of radiotherapy planning. Specifically, we aimed to identify par...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-018-4180-3

    authors: Lundemann M,Munck Af Rosenschöld P,Muhic A,Larsen VA,Poulsen HS,Engelholm SA,Andersen FL,Kjær A,Larsson HBW,Law I,Hansen AE

    更新日期:2019-03-01 00:00:00

  • Comparison of (18)F-FLT PET and (18)F-FDG PET for preoperative staging in non-small cell lung cancer.

    abstract:PURPOSE:The nucleoside analog 3'-deoxy-3'-(18)F-fluorothymidine (FLT) has been introduced for imaging cell proliferation with positron emission tomography (PET). We prospectively compared the diagnostic efficacy of FLT PET with that of 2-deoxy-2-(18)F-fluoro-D-glucose (FDG) PET for the preoperative nodal and distant me...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-007-0613-0

    authors: Yamamoto Y,Nishiyama Y,Kimura N,Ishikawa S,Okuda M,Bandoh S,Kanaji N,Asakura M,Ohkawa M

    更新日期:2008-02-01 00:00:00

  • From metabolic connectivity to molecular connectivity: application to dopaminergic pathways.

    abstract:INTRODUCTION:This study aims to reveal the feasibility and potential of molecular connectivity based on neurotransmission in comparison with the metabolic connectivity with an application to dopaminergic pathways. For this purpose, we propose to compare the neurotransmission connectivity findings using 123I-FP-CIT SPEC...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-019-04574-3

    authors: Verger A,Horowitz T,Chawki MB,Eusebio A,Bordonne M,Azulay JP,Girard N,Guedj E

    更新日期:2020-02-01 00:00:00

  • Astrocytosis measured by ¹¹C-deprenyl PET correlates with decrease in gray matter density in the parahippocampus of prodromal Alzheimer's patients.

    abstract:PURPOSE:The Alzheimer's disease (AD) pathology is characterized by fibrillar amyloid deposits and neurofibrillary tangles, as well as the activation of astrocytosis, microglia activation, atrophy, dysfunctional synapse, and cognitive impairments. The aim of this study was to test the hypothesis that astrocytosis is cor...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-014-2859-7

    authors: Choo IL,Carter SF,Schöll ML,Nordberg A

    更新日期:2014-11-01 00:00:00

  • Clinical value of somatostatin receptor imaging in patients with suspected head and neck paragangliomas.

    abstract::Paragangliomas or glomus tumours of the head and neck region are rare somatostatin receptor-expressing neuroendocrine tumours. Precise preoperative diagnosis is of special importance in order to adequately weigh the potential benefit of the operation against the inherent risks of the procedure. In this study, the clin...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-002-0939-6

    authors: Schmidt M,Fischer E,Dietlein M,Michel O,Weber K,Moka D,Stennert E,Schicha H

    更新日期:2002-12-01 00:00:00

  • 18F-FDG PET-CT uptake is a feature of both normal diameter and aneurysmal aortic wall and is not related to aneurysm size.

    abstract:PURPOSE:Aortic metabolic activity is suggested to correlate with presence and progression of aneurysmal disease, but has been inadequately studied. This study investigates the 2-[(18)F] fluoro-2-deoxy-D-glucose ((18)F-FDG) uptake in a population of infra-renal abdominal aortic aneurysms (AAA), compared to a matched non...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-014-2865-9

    authors: Barwick TD,Lyons OT,Mikhaeel NG,Waltham M,O'Doherty MJ

    更新日期:2014-12-01 00:00:00

  • Effect of attenuation correction on the interpretation of 99mTc-sestamibi myocardial perfusion scintigraphy: the impact of 1 year's experience.

    abstract::The aim of this study was to determine the yield of attenuation correction in myocardial perfusion imaging (MPI), before and after a 1-year experience period. In 48 consecutive patients referred for MPI, both non-corrected (NC) and attenuation-corrected (AC) images were analysed by three independent readers shortly af...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-003-1265-3

    authors: Slart RH,Que TH,van Veldhuisen DJ,Poot L,Blanksma PK,Piers DA,Jager PL

    更新日期:2003-11-01 00:00:00

  • (11)C-Choline PET/CT in patients with hormone-resistant prostate cancer showing biochemical relapse after radical prostatectomy.

    abstract:PURPOSE:To determine the diagnostic efficacy of (11)C-choline PET/CT in patients with prostate cancer (PC) after radical prostatectomy who presented with increasing PSA levels during follow-up in spite of being on hormone treatment (HT), and therefore showing HT resistance. METHODS:We evaluated a large series of 157 c...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-012-2272-z

    authors: Ceci F,Castellucci P,Mamede M,Schiavina R,Rubello D,Fuccio C,Ambrosini V,Boschi S,Martorana G,Fanti S

    更新日期:2013-01-01 00:00:00

  • Dosimetric parameters predicting contralateral liver hypertrophy after unilobar radioembolization of hepatocellular carcinoma.

    abstract:PURPOSE:This study aimed at identifying prior therapy dosimetric parameters using 99mTc-labeled macro-aggregates of albumin (MAA) that are associated with contralateral hepatic hypertrophy occurring after unilobar radioembolization of hepatocellular carcinoma (HCC) performed with 90Y-loaded glass microspheres. METHODS...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-017-3845-7

    authors: Palard X,Edeline J,Rolland Y,Le Sourd S,Pracht M,Laffont S,Lenoir L,Boudjema K,Ugen T,Brun V,Mesbah H,Haumont LA,Loyer P,Garin E

    更新日期:2018-03-01 00:00:00

  • Automated analysis of small animal PET studies through deformable registration to an atlas.

    abstract:PURPOSE:This work aims to develop a methodology for automated atlas-guided analysis of small animal positron emission tomography (PET) data through deformable registration to an anatomical mouse model. METHODS:A non-rigid registration technique is used to put into correspondence relevant anatomical regions of rodent C...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-012-2188-7

    authors: Gutierrez DF,Zaidi H

    更新日期:2012-11-01 00:00:00

  • [99mTc]Demotensin 5 and 6 in the NTS1-R-targeted imaging of tumours: synthesis and preclinical results.

    abstract:PURPOSE:The aim of this study was to evaluate the applicability of [(99m)Tc]Demotensin 5 and 6 [Formula: see text] in the targeted diagnostic imaging of neurotensin subtype 1 receptor (NTS1-R)-expressing tumours. METHODS:Labelling of Demotensin 5 and 6 with (99m)Tc was conducted by brief incubation with (99m)TcO(4) (-...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-007-0489-z

    authors: Maina T,Nikolopoulou A,Stathopoulou E,Galanis AS,Cordopatis P,Nock BA

    更新日期:2007-11-01 00:00:00

  • Targeted alpha therapy in vivo: direct evidence for single cancer cell kill using 149Tb-rituximab.

    abstract::This study demonstrates high-efficiency sterilisation of single cancer cells in a SCID mouse model of leukaemia using rituximab, a monoclonal antibody that targets CD20, labelled with terbium-149, an alpha-emitting radionuclide. Radio-immunotherapy with 5.5 MBq labelled antibody conjugate (1.11 GBq/mg) 2 days after an...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-003-1413-9

    authors: Beyer GJ,Miederer M,Vranjes-Durić S,Comor JJ,Künzi G,Hartley O,Senekowitsch-Schmidtke R,Soloviev D,Buchegger F

    更新日期:2004-04-01 00:00:00

  • Value of (18)F-FDG PET/CT for therapeutic assessment of patients with polymyalgia rheumatica receiving tocilizumab as first-line treatment.

    abstract:PURPOSE:To evaluate the use of (18)F-FDG PET/CT for the assessment of tocilizumab (TCZ) as first-line treatment in patients with polymyalgia rheumatica (PMR). METHODS:Patients with PMR were prospectively enrolled in a multicentre clinical trial assessing TCZ therapy (the TENOR trial). The patients underwent FDG PET/CT...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00259-015-3287-z

    authors: Palard-Novello X,Querellou S,Gouillou M,Saraux A,Marhadour T,Garrigues F,Abgral R,Salaün PY,Devauchelle-Pensec V

    更新日期:2016-04-01 00:00:00

  • Diagnosis of recurrent prostate cancer with PET/CT imaging using the gastrin-releasing peptide receptor antagonist 68Ga-RM2: Preliminary results in patients with negative or inconclusive [18F]Fluoroethylcholine-PET/CT.

    abstract:PURPOSE/BACKGROUND:[18F]fluoroethylcholine (18FECH) has been shown to be a valuable PET-tracer in recurrent prostate cancer (PCa), but still has limited accuracy. RM2 is a gastrin-releasing peptide receptor (GRPr) antagonist that binds to GRPr on PCa cells. Recent studies suggest that GRPr imaging with PET/CT is a prom...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-017-3702-8

    authors: Wieser G,Popp I,Christian Rischke H,Drendel V,Grosu AL,Bartholomä M,Weber WA,Mansi R,Wetterauer U,Schultze-Seemann W,Meyer PT,Jilg CA

    更新日期:2017-08-01 00:00:00

  • The value of 18F-FDG PET/CT in diagnosing infectious endocarditis.

    abstract:PURPOSE:Early detection of infectious endocarditis is challenging. For diagnosing infectious endocarditis, the revised Duke criteria are the gold standard. Evidence of endocardial involvement on echocardiography is a major criterion, but sensitivity and specificity of echocardiography are not optimal. Here we investiga...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-013-2376-0

    authors: Kouijzer IJ,Vos FJ,Janssen MJ,van Dijk AP,Oyen WJ,Bleeker-Rovers CP

    更新日期:2013-07-01 00:00:00

  • The effect of 18F-florbetapir dose reduction on region-based classification of cortical amyloid deposition.

    abstract:UNLABELLED:There are specific dose recommendations for diagnostic amyloid PET imaging with 18F-florbetapir, but they may not apply to research studies using regional quantitative analysis. We, therefore, studied the effect of tracer dose reduction on the discriminative power of regional analysis. METHODS:Using bootstr...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-014-2842-3

    authors: Herholz K,Evans R,Anton-Rodriguez J,Hinz R,Matthews JC

    更新日期:2014-11-01 00:00:00

  • Differentiation of treatment-related changes from tumour progression: a direct comparison between dynamic FET PET and ADC values obtained from DWI MRI.

    abstract:BACKGROUND:Following brain cancer treatment, the capacity of anatomical MRI to differentiate neoplastic tissue from treatment-related changes (e.g., pseudoprogression) is limited. This study compared apparent diffusion coefficients (ADC) obtained by diffusion-weighted MRI (DWI) with static and dynamic parameters of O-(...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-019-04384-7

    authors: Werner JM,Stoffels G,Lichtenstein T,Borggrefe J,Lohmann P,Ceccon G,Shah NJ,Fink GR,Langen KJ,Kabbasch C,Galldiks N

    更新日期:2019-08-01 00:00:00

  • Specific efficacy of peptide receptor radionuclide therapy with (177)Lu-octreotate in advanced neuroendocrine tumours of the small intestine.

    abstract:PURPOSE:Increasing evidence supports the value of peptide receptor radionuclide therapy (PRRT) in patients with metastatic neuroendocrine tumours (NET), but there are limited data on its specific efficacy in NET of small intestinal (midgut) origin. This study aims to define the benefit of PRRT with (177)Lu-octreotate f...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-015-3041-6

    authors: Sabet A,Dautzenberg K,Haslerud T,Aouf A,Sabet A,Simon B,Mayer K,Biersack HJ,Ezziddin S

    更新日期:2015-07-01 00:00:00

  • Regional distribution and kinetics of [18F]fluciclovine (anti-[18F]FACBC), a tracer of amino acid transport, in subjects with primary prostate cancer.

    abstract:PURPOSE:[(18)F]Fluciclovine (anti-[(18)F]FACBC) is a synthetic amino acid developed for PET assessment of the anabolic component of tumour metabolism in clinical routine. This phase 1 trial evaluated the safety, tracer stability and uptake kinetics of [(18)F]fluciclovine in patients. METHODS:Six patients with biopsy-p...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-012-2291-9

    authors: Sörensen J,Owenius R,Lax M,Johansson S

    更新日期:2013-02-01 00:00:00