Assessing the role of ¹⁸F-FDG PET and ¹⁸F-FDG PET/CT in the diagnosis of soft tissue musculoskeletal malignancies: a systematic review and meta-analysis.

Abstract:

PURPOSE:Twelve years ago a meta-analysis evaluated the diagnostic performance of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in assessing musculoskeletal soft tissue lesions (MsSTL). Currently, PET/CT has substituted PET imaging; however, there has not been any published meta-analysis on the use of PET/CT or a comparison of PET/CT with PET in the diagnosis of MsSTL. Therefore, we conducted a meta-analysis to identify the current diagnostic performance of (18)F-FDG PET/CT and determine if there is added value when compared to PET. METHODS:A systematic review of English articles was conducted, and MEDLINE PubMed, the Cochrane Library, and Embase were searched from 1996 to March 2015. Studies exploring the diagnostic accuracy of (18)F-FDG PET/CT (or dedicated PET) compared to histopathology in patients with MsSTL undergoing investigation for malignancy were included. RESULTS:Our meta-analysis included 14 articles composed of 755 patients with 757 soft tissue lesions. There were 451 (60 %) malignant tumors and 306 benign lesions. The (18)F-FDG PET/CT (and dedicated PET) mean sensitivity, specificity, accuracy, positive predictive value, and negative predictive value for diagnosing MsSTL were 0.96 (0.90, 1.00), 0.77 (0.67, 0.86), 0.88 (0.85, 0.91), 0.86 (0.78, 0.94), and 0.91 (0.83, 0.99), respectively. The posterior mean (95 % highest posterior density interval) for the AUC was 0.92 (0.88, 0.96). PET/CT had higher specificity, accuracy, and positive predictive value when compared to a dedicated PET (0.85, 0.89, and 0.91 vs 0.71, 0.85, and 0.82, respectively). CONCLUSION:(18)F-FDG PET/CT and dedicated PET are both highly accurate in the diagnosis of MsSTL. PET/CT is more accurate and specific and has a higher positive predictive value than PET.

authors

Etchebehere EC,Hobbs BP,Milton DR,Malawi O,Patel S,Benjamin RS,Macapinlac HA

doi

10.1007/s00259-015-3242-z

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

860-870

issue

5

eissn

1619-7070

issn

1619-7089

pii

10.1007/s00259-015-3242-z

journal_volume

43

pub_type

杂志文章,meta分析,评审
  • Comparison of hybrid (68)Ga-PSMA PET/MRI and (68)Ga-PSMA PET/CT in the evaluation of lymph node and bone metastases of prostate cancer.

    abstract:PURPOSE:To evaluate the reproducibility of the combination of hybrid PET/MRI and the (68)Ga-PSMA-11 tracer in depicting lymph node (LN) and bone metastases of prostate cancer (PC) in comparison with that of PET/CT. MATERIALS AND METHODS:A retrospective analysis of 26 patients who were subjected to (68)Ga-PSMA PET/CTlo...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-015-3206-3

    authors: Freitag MT,Radtke JP,Hadaschik BA,Kopp-Schneider A,Eder M,Kopka K,Haberkorn U,Roethke M,Schlemmer HP,Afshar-Oromieh A

    更新日期:2016-01-01 00:00:00

  • PET imaging evaluation of [(18)F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates.

    abstract:PURPOSE:Positron emission tomography (PET) radioligands specific to α7 nicotinic acetylcholine receptors (nAChRs) afford in vivo imaging of this receptor for neuropathologies such as Alzheimer's disease, schizophrenia, and substance abuse. This work aims to characterize the kinetic properties of an α7-nAChR-specific ra...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-015-3209-0

    authors: Hillmer AT,Zheng MQ,Li S,Scheunemann M,Lin SF,Holden D,Labaree D,Ropchan J,Teodoro R,Deuther-Conrad W,Carson RE,Brust P,Huang Y

    更新日期:2016-03-01 00:00:00

  • Targeted alpha therapy in vivo: direct evidence for single cancer cell kill using 149Tb-rituximab.

    abstract::This study demonstrates high-efficiency sterilisation of single cancer cells in a SCID mouse model of leukaemia using rituximab, a monoclonal antibody that targets CD20, labelled with terbium-149, an alpha-emitting radionuclide. Radio-immunotherapy with 5.5 MBq labelled antibody conjugate (1.11 GBq/mg) 2 days after an...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-003-1413-9

    authors: Beyer GJ,Miederer M,Vranjes-Durić S,Comor JJ,Künzi G,Hartley O,Senekowitsch-Schmidtke R,Soloviev D,Buchegger F

    更新日期:2004-04-01 00:00:00

  • PET imaging biomarkers in head and neck cancer.

    abstract::In locally advanced head and neck squamous cell carcinoma (HNSCC), the role of imaging becomes more and more critical in the management process. In this framework, molecular imaging techniques such as PET allow noninvasive assessment of a range of tumour biomarkers such as metabolism, hypoxia and proliferation, which ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,评审

    doi:10.1007/s00259-014-2972-7

    authors: Differding S,Hanin FX,Grégoire V

    更新日期:2015-04-01 00:00:00

  • Effects of the COVID-19 pandemic on myocardial perfusion imaging for ischemic heart disease.

    abstract:PURPOSE:We assessed the effects of the COVID-19 pandemic on myocardial perfusion imaging (MPI) for ischemic heart disease during the lockdown imposed by the Italian Government. METHODS:We retrospectively reviewed the number and the findings of stress single-photon emission computed tomography (SPECT)-MPI performed bet...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-020-04994-6

    authors: Nappi C,Megna R,Acampa W,Assante R,Zampella E,Gaudieri V,Mannarino T,Green R,Cantoni V,Petretta M,Cuocolo A

    更新日期:2021-02-01 00:00:00

  • Comparison of the prognostic value of SPECT after nitrate administration and metabolic imaging by PET in patients with ischaemic left ventricular dysfunction.

    abstract:PURPOSE:We compared the prognostic value of 99mTc-tetrofosmin single-photon emission computed tomography (SPECT) after nitrate administration and positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in patients with ischaemic left ventricular (LV) dysfunction. METHODS:Eighty-nine patients with previous...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-006-0304-2

    authors: Sorrentino AR,Acampa W,Petretta M,Mainolfi C,Salvatore M,Cuocolo A

    更新日期:2007-04-01 00:00:00

  • Uptake kinetics and biodistribution of 14C-D-luciferin--a radiolabeled substrate for the firefly luciferase catalyzed bioluminescence reaction: impact on bioluminescence based reporter gene imaging.

    abstract:PURPOSE:Firefly luciferase catalyzes the oxidative decarboxylation of D: -luciferin to oxyluciferin in the presence of cofactors, producing bioluminescence. This reaction is used in optical bioluminescence-based molecular imaging approaches to detect the expression of the firefly luciferase reporter gene. Biokinetics a...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-008-0870-6

    authors: Berger F,Paulmurugan R,Bhaumik S,Gambhir SS

    更新日期:2008-12-01 00:00:00

  • Inter-institution preference-based variability of ejection fraction and volumes using quantitative gated SPECT with 99mTc-tetrofosmin: a multicentre study involving 106 hospitals.

    abstract:PURPOSE:Inter-institution reproducibility of gated SPECT quantification based on institutional preferences was evaluated. This sort of variability is crucial for a multicentre study when many hospitals are involved. METHODS:A total of 106 institutes participated in this study and were grouped according to their use of...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00259-005-1916-7

    authors: Nakajima K,Nishimura T

    更新日期:2006-02-01 00:00:00

  • 18F-Fluorodeoxyglucose positron emission tomography pulmonary imaging in idiopathic pulmonary fibrosis is reproducible: implications for future clinical trials.

    abstract:PURPOSE:Noninvasive markers of disease activity in patients with idiopathic pulmonary fibrosis (IPF) are lacking. We performed this study to investigate the reproducibility of pulmonary (18)F-FDG PET/CT in patients with IPF. METHODS:The study group comprised 13 patients (11 men, 2 women; mean age 71.1 ± 9.9 years) wit...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-011-1986-7

    authors: Win T,Lambrou T,Hutton BF,Kayani I,Screaton NJ,Porter JC,Maher TM,Endozo R,Shortman RI,Lukey P,Groves AM

    更新日期:2012-03-01 00:00:00

  • Efficacy of cell proliferation imaging with 4DST PET/CT for predicting the prognosis of patients with esophageal cancer: a comparison study with FDG PET/CT.

    abstract:PURPOSE:4'-[Methyl-11C] thiothymidine (4DST) incorporates into DNA directly and is a PET tracer used for cell proliferation imaging. The aim of this study was to evaluate the prediction of prognosis with pretreatment 4DST PET/CT compared to fluorodeoxyglucose (FDG) PET/CT in patients with esophageal cancer. METHODS:In...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-020-05179-x

    authors: Hotta M,Minamimoto R,Toyohara J,Nohara K,Nakajima K,Takase K,Yamada K

    更新日期:2021-01-12 00:00:00

  • Yttrium-90 glass microspheres radioembolization (RE) for biliary tract cancer: a large single-center experience.

    abstract:PURPOSE:Radioembolization (RE) is a promising treatment option for biliary tract cancers (BTC). We report here the largest series to date using this treatment modality. METHODS:We retrospectively studied data from 64 patients treated outside prospective clinical trial at our institution. We studied baseline characteri...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-018-4199-5

    authors: Bourien H,Palard X,Rolland Y,Le Du F,Beuzit L,Uguen T,Le Sourd S,Pracht M,Manceau V,Lièvre A,Boudjema K,Garin E,Edeline J

    更新日期:2019-03-01 00:00:00

  • Hypertension complicating 131I-meta-iodobenzylguanidine therapy for neuroblastoma.

    abstract:PURPOSE:Radiolabelled meta-iodobenzylguanidine (mIBG), used as targeted therapy for neuroblastoma, is known to have effects on blood pressure (BP). In this study we audited BP changes in patients receiving (131)I-mIBG therapy for neuroblastoma to identify BP-related adverse events (AE) and possible predictive factors. ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-011-2022-7

    authors: Kosmin MA,Bomanji JB,Cork NJ,Shankar A,Gaze MN

    更新日期:2012-04-01 00:00:00

  • Liver tumor F-18 FDG-PET before and immediately after microwave ablation enables imaging and quantification of tumor tissue contraction.

    abstract:PURPOSE:Poor liver tumor visibility after microwave ablation (MWA) limits direct tumor ablation margin assessments using contrast-enhanced CT or ultrasound (US). Positron emission tomography (PET) or PET/CT may offer improved intraprocedural assessment of liver tumor ablation margins versus current imaging techniques, ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-020-05104-2

    authors: Yan Z,Khorasani R,Levesque VM,Gerbaudo VH,Shyn PB

    更新日期:2020-11-11 00:00:00

  • Metabolic and morphological measurements of subcutaneous and visceral fat and their relationship with disease stage and overall survival in newly diagnosed pancreatic adenocarcinoma : Metabolic and morphological fat measurements in pancreatic adenocarcino

    abstract:PURPOSE:The relationship between tumor metabolism and stage, subcutaneous and visceral fat thickness, and their glucose metabolism and overall survival in patients recently diagnosed with pancreatic carcinoma was assessed. METHODS:Thirty-eight consecutive patients were studied. Subcutaneous fat thickness (SFT), viscer...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-016-3525-z

    authors: Van de Wiele C,Van Vlaenderen M,D'Hulst L,Delcourt A,Copin D,De Spiegeleer B,Maes A

    更新日期:2017-01-01 00:00:00

  • Radioembolisation in patients with hepatocellular carcinoma that have previously received liver-directed therapies.

    abstract:PURPOSE:Radioembolisation is part of the multimodal treatment of hepatocellular carcinoma (HCC) at specialist liver centres. This study analysed the impact of prior treatment on tolerability and survival following radioembolisation. METHODS:This was a retrospective analysis of 325 consecutive patients with a confirmed...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-018-3968-5

    authors: Sangro B,Maini CL,Ettorre GM,Cianni R,Golfieri R,Gasparini D,Ezziddin S,Paprottka PM,Fiore F,Van Buskirk M,Bilbao JI,Salvatori R,Giampalma E,Geatti O,Wilhelm K,Hoffmann RT,Izzo F,Iñarrairaegui M,Urigo C,Cappelli A,

    更新日期:2018-09-01 00:00:00

  • Comparison of the pharmacokinetics of 68Ga-DOTATOC and [18F]FDG in patients with metastatic neuroendocrine tumours scheduled for 90Y-DOTATOC therapy.

    abstract:PURPOSE:The purpose of this study was to evaluate and compare, by means of dynamic PET, the pharmacokinetics of 68Ga-DOTATOC, a tracer which reflects the expression of somatostatin receptors (SSTRs), and of [18F]FDG, a marker of tumour viability, in patients with metastatic neuroendocrine tumours (NETs) in whom 90Y-DOT...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-006-0110-x

    authors: Koukouraki S,Strauss LG,Georgoulias V,Eisenhut M,Haberkorn U,Dimitrakopoulou-Strauss A

    更新日期:2006-10-01 00:00:00

  • Effects of partial volume correction on discrimination between very early Alzheimer's dementia and controls using brain perfusion SPECT.

    abstract::We assessed the accuracy of brain perfusion single-photon emission computed tomography (SPECT) in discriminating between patients with probable Alzheimer's disease (AD) at the very early stage and age-matched controls before and after partial volume correction (PVC). Three-dimensional MRI was used for PVC. We randomly...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00259-004-1491-3

    authors: Kanetaka H,Matsuda H,Asada T,Ohnishi T,Yamashita F,Imabayashi E,Tanaka F,Nakano S,Takasaki M

    更新日期:2004-07-01 00:00:00

  • In-vivo comparison of the acute retention of stem cell derivatives and fibroblasts after intramyocardial transplantation in the mouse model.

    abstract:PURPOSE:Various strategies have been applied to increase the engraftment of an intramyocardial cell transplant (Tx) to treat ischemic myocardium. Thereby, co-transplanted fibroblasts (FB) improve the long-term survival of stem cell derivatives (SCD) in a murine model of myocardial infarction. For therapeutic use, the t...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-014-2858-8

    authors: Lang C,Lehner S,Todica A,Boening G,Zacherl M,Franz WM,Krause BJ,Bartenstein P,Hacker M,David R

    更新日期:2014-12-01 00:00:00

  • Clinical value of negative 68Ga-PSMA PET/CT in the management of biochemical recurrent prostate cancer patients.

    abstract:PURPOSE:To evaluate the clinical value of 68Ga-PSMA PET/CT negativity in patients with biochemical recurrent prostate cancer (BCR). METHODS:One hundred three BCR patients (median age, 70 years; median PSA, 0.47 ng/mL) with negative 68Ga-PSMA PET/CT, followed up for at least 1 year, were retrospectively identified in a...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-020-04914-8

    authors: Celli M,De Giorgi U,Caroli P,Di Iorio V,Fantini L,Rossetti V,Foca F,Nicolini S,Giganti M,Paganelli G,Matteucci F

    更新日期:2021-01-01 00:00:00

  • The role of bone SPECT/CT in patients with persistent or recurrent lumbar pain following lumbar spine stabilization surgery.

    abstract:PURPOSE:Despite recent advances in lumbar spine stabilization surgery (LSSS), a high number of patients continue to complain of persistent/recurrent lumbar pain after LSSS. Conventional imaging (plain radiography, CT and MRI) is commonly performed to assess potential lumbar pain generators, but findings are equivocal i...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-018-4141-x

    authors: Al-Riyami K,Vöö S,Gnanasegaran G,Pressney I,Meir A,Casey A,Molloy S,Allibone J,Bomanji J

    更新日期:2019-04-01 00:00:00

  • The value of 18F-choline PET/CT in patients with elevated PSA-level and negative prostate needle biopsy for localisation of prostate cancer.

    abstract:PURPOSE:Patients with persistent elevated PSA and repeated negative prostate biopsy, that means having the prostate biopsied at multiple times, were investigated with 18F-choline PET/CT to delineate prostate cancer and guide renewed prostate biopsy. METHODS:Twenty patients with elevated PSA and negative prostate biops...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-007-0686-9

    authors: Igerc I,Kohlfürst S,Gallowitsch HJ,Matschnig S,Kresnik E,Gomez-Segovia I,Lind P

    更新日期:2008-05-01 00:00:00

  • Investigation into the mechanisms of vagus nerve stimulation for the treatment of intractable epilepsy, using 99mTc-HMPAO SPET brain images.

    abstract::Vagus nerve stimulation (VNS) has gained recognition as a treatment for refractory epilepsies where surgical treatment is not possible. While it appears that this treatment is effective in some patients, the mechanism of action is not clearly understood. The purpose of this study was to clarify findings of other posit...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-002-1026-8

    authors: Barnes A,Duncan R,Chisholm JA,Lindsay K,Patterson J,Wyper D

    更新日期:2003-02-01 00:00:00

  • Electrocardiographic-gated dual-isotope simultaneous acquisition SPECT using 18F-FDG and 99mTc-sestamibi to assess myocardial viability and function in a single study.

    abstract:PURPOSE:Dual-isotope simultaneous acquisition single-photon emission computed tomography (DISA SPECT) with 18F-fluorodeoxyglucose (FDG) and (99m)Tc-sestamibi appears attractive for the detection of viable myocardium because it permits simultaneous assessment of glucose utilisation and perfusion. Another potential benef...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-004-1668-9

    authors: Matsunari I,Kanayama S,Yoneyama T,Matsudaira M,Nakajima K,Taki J,Nekolla SG,Tonami N,Hisada K

    更新日期:2005-02-01 00:00:00

  • Comparison of MRI, [18F]FDG PET/CT, and 99mTc-UBI 29-41 scintigraphy for postoperative spondylodiscitis-a prospective multicenter study.

    abstract:PURPOSE:Postoperative infection still constitutes an important complication of spine surgery, and the optimal imaging modality for diagnosing postoperative spine infection has not yet been established. The aim of this prospective multicenter study was to assess the diagnostic performance of three imaging modalities in ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-020-05109-x

    authors: Paez D,Sathekge MM,Douis H,Giammarile F,Fatima S,Dhal A,Puri SK,Erba PA,Lazzeri E,Ferrando R,Filho PA,Magboo VP,Morozova O,Núñez R,Pellet O,Mariani G

    更新日期:2020-11-18 00:00:00

  • FDG PET as a prognostic predictor in the early post-therapeutic evaluation for unresectable hepatocellular carcinoma.

    abstract:PURPOSE:To elucidate the prognostic role of post-therapeutic (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET), we conducted a retrospective cohort study analysing the clinical factors that affect overall survival after non-operative therapy for unresectable hepatocellular carcinoma (HCC). METHOD...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-009-1284-9

    authors: Higashi T,Hatano E,Ikai I,Nishii R,Nakamoto Y,Ishizu K,Suga T,Kawashima H,Togashi K,Seo S,Kitamura K,Takada Y,Uemoto S

    更新日期:2010-03-01 00:00:00

  • Glucagon-like peptide-1 receptor imaging with [Lys40(Ahx-HYNIC- 99mTc/EDDA)NH2]-exendin-4 for the detection of insulinoma.

    abstract:PURPOSE:The objective of this article is to present a new method for the diagnosis of insulinoma with the use of [Lys(40)(Ahx-HYNIC-(99m)Tc/EDDA)NH2]-exendin-4. METHODS:Studies were performed in 11 patients with negative results of all available non-isotopic diagnostic methods (8 with symptoms of insulinoma, 2 with ma...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-012-2299-1

    authors: Sowa-Staszczak A,Pach D,Mikołajczak R,Mäcke H,Jabrocka-Hybel A,Stefańska A,Tomaszuk M,Janota B,Gilis-Januszewska A,Małecki M,Kamiński G,Kowalska A,Kulig J,Matyja A,Osuch C,Hubalewska-Dydejczyk A

    更新日期:2013-04-01 00:00:00

  • Effects of arm truncation on the appearance of the halo artifact in 68Ga-PSMA-11 (HBED-CC) PET/MRI.

    abstract:PURPOSE:PSMA ligand imaging with hybrid PET/MRI scanners could be an integral part of the clinical routine in the future. However, the first study about this novel method revealed a severe photopenic artifact ("halo artifact") around the urinary bladder causing significantly reduced tumor visibility. The aim of this ev...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-017-3718-0

    authors: Afshar-Oromieh A,Wolf M,Haberkorn U,Kachelrieß M,Gnirs R,Kopka K,Schlemmer HP,Freitag MT

    更新日期:2017-09-01 00:00:00

  • 188Re-loaded lipid nanocapsules as a promising radiopharmaceutical carrier for internal radiotherapy of malignant gliomas.

    abstract:PURPOSE:Lipid nanocapsules (LNC) entrapping lipophilic complexes of (188)Re ((188)Re(S(3)CPh)(2)(S(2)CPh) [(188)Re-SSS]) were investigated as a novel radiopharmaceutical carrier for internal radiation therapy of malignant gliomas. The present study was designed to evaluate the efficacy of intra-cerebral administration ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-008-0735-z

    authors: Allard E,Hindre F,Passirani C,Lemaire L,Lepareur N,Noiret N,Menei P,Benoit JP

    更新日期:2008-10-01 00:00:00

  • Ictal brain SPET during seizures pharmacologically provoked with pentylenetetrazol: a new diagnostic procedure in drug-resistant epileptic patients.

    abstract::Functional brain imaging plays an important role in seizure focus localisation. However, truly ictal single-photon emission tomography (SPET) studies are not routinely performed owing to technical problems associated with the use of tracers and methodological and logistical difficulties. In this study we tried to reso...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-002-0879-1

    authors: Calcagni ML,Giordano A,Bruno I,Parbonetti G,Di Giuda D,De Rossi G,Troncone L,Colicchio G

    更新日期:2002-10-01 00:00:00

  • Detection and cellular localisation of the synthetic soluble macromolecular drug carrier pHPMA.

    abstract::Synthetic macromolecules such as copolymers of N-(2-hydroxypropyl)methacrylamide (pHPMA) are potential carriers for the delivery of drugs owing to their ability to passively accumulate in solid tumours [enhanced permeation and retention (EPR) effect]. To gain further knowledge about the biodistribution and the cellula...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-002-0835-0

    authors: Kissel M,Peschke P,Subr V,Ulbrich K,Strunz AM,Kühnlein R,Debus J,Friedrich E

    更新日期:2002-08-01 00:00:00