abstract：PURPOSE:We assessed the effects of the COVID-19 pandemic on myocardial perfusion imaging (MPI) for ischemic heart disease during the lockdown imposed by the Italian Government. METHODS:We retrospectively reviewed the number and the findings of stress single-photon emission computed tomography (SPECT)-MPI performed bet...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nappi C,Megna R,Acampa W,Assante R,Zampella E,Gaudieri V,Mannarino T,Green R,Cantoni V,Petretta M,Cuocolo A

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:Positron emission tomography (PET) has been widely utilized in the study of traumatic brain injury (TBI) for decades. While most applications of PET have attempted to assess neuronal function after TBI, more recently, novel radiotracers have sought to image biomarkers in the context of TBI and chronic traumatic...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ayubcha C,Revheim ME,Newberg A,Moghbel M,Rojulpote C,Werner TJ,Alavi A

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) is used for (re)staging prostate cancer (PCa) and as a biomarker for evaluating response to therapy, but lacks established response criteria. A panel of PCa experts in nuclear medicine, radiology, and/or urolog...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Fanti S,Goffin K,Hadaschik BA,Herrmann K,Maurer T,MacLennan S,Oprea-Lager DE,Oyen WJ,Rouvière O,Mottet N,Bjartell A

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:The objective of this study was to evaluate whether 68Ga-PSMA PET/CT whole-body tumor burden (PSMAwbtb) is associated with clinical parameters and laboratory parameters in prostate cancer patients. METHODS:We retrospectively evaluated prostate cancer patients submitted to PSMA PET/CT for primary staging purpos...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Santos A,Mattiolli A,Carvalheira JB,Ferreira U,Camacho M,Silva C,Costa F,Matheus W,Lima M,Etchebehere E

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:There are controversial debates if patients with Hürthle cell carcinoma, also known as oxyphilic or oncocytic cell follicular thyroid carcinoma, have a poorer outcome. In this study, we systematically evaluated the clinical outcome in a large patient cohort following thyroidectomy and initial I-131 radioactive ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Wenter V,Albert NL,Unterrainer M,Ahmaddy F,Ilhan H,Jellinek A,Knösel T,Bartenstein P,Spitzweg C,Lehner S,Todica A

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:Tau pathology progression in Alzheimer's disease (AD) is explained through the network degeneration hypothesis and the neuropathological Braak stages; however, the compatibility of these models remains unclear. METHODS:We utilized [18F]AV-1451 tau-PET scans of 39 subjects with AD and 39 sex-matched amyloid-neg...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Seemiller J,Bischof GN,Hoenig MC,Tahmasian M,van Eimeren T,Drzezga A,and the Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2021-01-18 00:00:00

abstract：PURPOSE:4'-[Methyl-11C] thiothymidine (4DST) incorporates into DNA directly and is a PET tracer used for cell proliferation imaging. The aim of this study was to evaluate the prediction of prognosis with pretreatment 4DST PET/CT compared to fluorodeoxyglucose (FDG) PET/CT in patients with esophageal cancer. METHODS:In...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Hotta M,Minamimoto R,Toyohara J,Nohara K,Nakajima K,Takase K,Yamada K

更新日期：2021-01-12 00:00:00

abstract：PURPOSE:This study aimed to establish an effective nomogram to predict primary distant metastasis (DM) in patients with nasopharyngeal carcinoma (NPC) to guide the application of PET/CT. METHODS:In total, 3591 patients with pathologically confirmed NPC were consecutively enrolled. The nomogram was constructed based on...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Xiao BB,Lin DF,Sun XS,Zhang X,Guo SS,Liu LT,Luo DH,Sun R,Wen YF,Li JB,Lv XF,Han LJ,Yuan L,Liu SL,Tang QN,Liang YJ,Li XY,Guo L,Chen QY,Fan W,Mai HQ,Tang LQ

更新日期：2021-01-08 00:00:00

abstract：PURPOSE:Standardized uptake value ratio (SUVr) used to quantify amyloid-β burden from amyloid-PET scans can be biased by variations in the tracer's nonspecific (NS) binding caused by the presence of cerebrovascular disease (CeVD). In this work, we propose a novel amyloid-PET quantification approach that harnesses the i...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Liu H,Nai YH,Saridin F,Tanaka T,O' Doherty J,Hilal S,Gyanwali B,Chen CP,Robins EG,Reilhac A

更新日期：2021-01-07 00:00:00

abstract：PURPOSE:Castration-resistant prostate cancer (CRPC) is the most common cause of death in men. The effectiveness of HDAC inhibitors has been demonstrated by preclinical models, but not in clinical studies, probably due to the ineffectively accumulation of HDACI in prostate cancer cells. The purpose of this work was to e...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Chen Z,Wang X,Yang X,Xu Y,Yang Y,Wang H,Li T,Bai P,Yuan G,Chen H,Yang J,Fiedler SA,Striar R,Bernales DR,Koegel RE,Cao Q,Ran C,Xiang B,Li H,Wang C

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:The emergence of the novel SARS-CoV-2 pathogen and lethal COVID-19 disease pandemic poses major diagnostic challenges. The study aims to describe the spectrum and prevalence of thoracic and extrathoracic incidental findings in patients who have undergone 18F-FDG PET/CT during the first 3 weeks of the COVID-19 U...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Halsey R,Priftakis D,Mackenzie S,Wan S,Davis LM,Lilburn D,Thornton A,Papathanasiou N,Gnanasegaran G,Bomanji J

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:To evaluate the clinical value of 68Ga-PSMA PET/CT negativity in patients with biochemical recurrent prostate cancer (BCR). METHODS:One hundred three BCR patients (median age, 70 years; median PSA, 0.47 ng/mL) with negative 68Ga-PSMA PET/CT, followed up for at least 1 year, were retrospectively identified in a...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Celli M,De Giorgi U,Caroli P,Di Iorio V,Fantini L,Rossetti V,Foca F,Nicolini S,Giganti M,Paganelli G,Matteucci F

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:In about 30% of patients treated with neoadjuvant chemoradiotherapy (nCRT) followed by surgical resection for locally advanced oesophageal cancer no vital tumour is found in the resection specimen. Accurate clinical response assessment is critical if deferral from surgery is considered in complete responders. O...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Vollenbrock SE,Voncken FEM,Lambregts DMJ,Maas M,Donswijk ML,Vegt E,Ter Beek LC,van Dieren JM,van Sandick JW,Aleman BMP,Beets-Tan RGH,Bartels-Rutten A

更新日期：2021-01-01 00:00:00

abstract：:Dynamic PET (dPET) studies have been used until now primarily within research purposes. Although it is generally accepted that the information provided by dPET is superior to that of conventional static PET acquisitions acquired usually 60 min post injection of the radiotracer, the duration of dynamic protocols, the l...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Dimitrakopoulou-Strauss A,Pan L,Sachpekidis C

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:Deposition of misfolded alpha-synuclein (αSYN) aggregates in the human brain is one of the major hallmarks of synucleinopathies. However, a target-specific tracer to detect pathological aggregates of αSYN remains lacking. Here, we report the development of a positron emission tomography (PET) tracer based on an...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kuebler L,Buss S,Leonov A,Ryazanov S,Schmidt F,Maurer A,Weckbecker D,Landau AM,Lillethorup TP,Bleher D,Saw RS,Pichler BJ,Griesinger C,Giese A,Herfert K

更新日期：2020-12-28 00:00:00

abstract：PURPOSE:Paired imaging/therapy with radiolabeled somatostatin receptor (SSTR) antagonists is a novel approach in neuroendocrine tumors (NETs). The aim of this study was to compare tumor uptake of 68Ga-DOTA-JR11 and 177Lu-satoreotide tetraxetan (177Lu-DOTA-JR11) in patients with NETs. METHODS:As part of a prospective c...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Krebs S,O'Donoghue JA,Biegel E,Beattie BJ,Reidy D,Lyashchenko SK,Lewis JS,Bodei L,Weber WA,Pandit-Taskar N

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:To know whether mild cognitive impairment (MCI) patients will develop Alzheimer's disease (AD) dementia in very short time or remain stable is of crucial importance, also considering new experimental drugs usually tested within very short time frames. Here we combined cerebrospinal fluid (CSF) AD biomarkers and...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Santangelo R,Masserini F,Agosta F,Sala A,Caminiti SP,Cecchetti G,Caso F,Martinelli V,Pinto P,Passerini G,Perani D,Magnani G,Filippi M

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:Postoperative infection still constitutes an important complication of spine surgery, and the optimal imaging modality for diagnosing postoperative spine infection has not yet been established. The aim of this prospective multicenter study was to assess the diagnostic performance of three imaging modalities in ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Paez D,Sathekge MM,Douis H,Giammarile F,Fatima S,Dhal A,Puri SK,Erba PA,Lazzeri E,Ferrando R,Filho PA,Magboo VP,Morozova O,Núñez R,Pellet O,Mariani G

更新日期：2020-11-18 00:00:00

abstract：AIMS:Perivascular fat attenuation index (FAI) has emerged as a novel coronary computed tomography angiography (CCTA)-based biomarker predicting cardiovascular outcomes by capturing early coronary inflammation. It is currently unknown whether FAI adds prognostic value beyond that provided by single-photon emission compu...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Bengs S,Haider A,Warnock GI,Fiechter M,Pargaetzi Y,Rampidis G,Etter D,Wijnen WJ,Portmann A,Osto E,Treyer V,Benz DC,Meisel A,Fuchs TA,Gräni C,Buechel RR,Kaufmann PA,Pazhenkottil AP,Gebhard C

更新日期：2020-11-16 00:00:00

abstract：PURPOSE:Poor liver tumor visibility after microwave ablation (MWA) limits direct tumor ablation margin assessments using contrast-enhanced CT or ultrasound (US). Positron emission tomography (PET) or PET/CT may offer improved intraprocedural assessment of liver tumor ablation margins versus current imaging techniques, ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Yan Z,Khorasani R,Levesque VM,Gerbaudo VH,Shyn PB

更新日期：2020-11-11 00:00:00

abstract：PURPOSE:We evaluated the value of reduced global and segmental absolute stress myocardial blood flow (sMBF) quantified by [15O] water positron emission tomography (PET) for predicting cardiac events in patients with suspected obstructive coronary artery disease (CAD). METHODS:Global and segmental sMBF during adenosine...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Harjulahti E,Maaniitty T,Nammas W,Stenström I,Biancari F,Bax JJ,Knuuti J,Saraste A

更新日期：2020-11-11 00:00:00

abstract：PURPOSE:Multiple myeloma (MM) is a bone marrow malignancy that remains mostly incurable. Elotuzumab is an FDA-approved therapeutic monoclonal antibody targeted to the cell surface glycoprotein CS1, which is overexpressed in MM cells. Identifying patients who will respond to CS1-targeted treatments such as elotuzumab re...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ghai A,Zheleznyak A,Mixdorf M,O'Neal J,Ritchey J,Rettig M,DiPersio J,Shokeen M,Achilefu S

更新日期：2020-11-11 00:00:00

abstract：:The figure is missing. ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Paepegaey AC,Cottereau AS,Dohan A,Gaujoux S,Triller MF,Sibony M,Groussin L,Libé R

更新日期：2020-11-06 00:00:00

abstract：PURPOSE:In vivo Alzheimer's disease (AD) biomarkers for tau pathology are cerebrospinal fluid (CSF) phosphorylated tau (p-tau) and [18F]flortaucipir positron emission tomography (PET). Our aim was to assess associations between CSF p-tau with [18F]flortaucipir PET and the associations of both tau biomarkers with cognit...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Wolters EE,Ossenkoppele R,Verfaillie SCJ,Coomans EM,Timmers T,Visser D,Tuncel H,Golla SSV,Windhorst AD,Boellaard R,van der Flier WM,Teunissen CE,Scheltens P,van Berckel BNM

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:The specific binding ratio (SBR) of 123I-FP-CIT (FP-CIT) in the putamen decreases with age by about 5% per decade and most likely is about 10% higher in females. However, the clinical utility of age and sex correction of the SBR is still a matter of debate. This study tested the impact of age and sex correction...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Schmitz-Steinkrüger H,Lange C,Apostolova I,Mathies FL,Frings L,Klutmann S,Hellwig S,Meyer PT,Buchert R

更新日期：2020-10-31 00:00:00

abstract：PURPOSE:Several patients experience unexplained persistent symptoms after SARS-CoV-2 recovering. We aimed at evaluating if 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) was able to demonstrate a persistent inflammatory process. METHODS:Recovered adult COVID-19 patients, who complained unexplained persisting symptoms for ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sollini M,Ciccarelli M,Cecconi M,Aghemo A,Morelli P,Gelardi F,Chiti A

更新日期：2020-10-30 00:00:00

abstract：PURPOSE:It was previously demonstrated that radiation effects can enhance the therapy outcome of immune checkpoint inhibitors. In this study, a syngeneic breast tumor mouse model was used to investigate the effect of [177Lu]Lu-DOTA-folate as an immune stimulus to enhance anti-CTLA-4 immunotherapy. METHODS:In vitro and...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Guzik P,Siwowska K,Fang HY,Cohrs S,Bernhardt P,Schibli R,Müller C

更新日期：2020-10-19 00:00:00

abstract：PURPOSE:The folate receptor (FR) is frequently overexpressed in a variety of tumor types and, hence, an interesting target for radionuclide therapy. The aim of this study was to evaluate a new class of albumin-binding radioconjugates comprising 5-methyltetrahydrofolate (5-MTHF) as a targeting agent and to compare their...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Guzik P,Benešová M,Ratz M,Monné Rodríguez JM,Deberle LM,Schibli R,Müller C

更新日期：2020-10-15 00:00:00

abstract：PURPOSE:To study the feasibility of the in vivo [18F]-DPA-714 TSPO positron emission tomography (PET) to detect glial activation in a rat model of progressive parkinsonism induced by viral-mediated overexpression of A53T mutated human α-synuclein (hα-syn) in the substantia nigra pars compacta (SNpc). METHODS:We conduc...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Rodríguez-Chinchilla T,Quiroga-Varela A,Molinet-Dronda F,Belloso-Iguerategui A,Merino-Galan L,Jimenez-Urbieta H,Gago B,Rodriguez-Oroz MC

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:The study aimed to compare the incidence of interstitial pneumonia on [18F]-FDG PET/CT scans between two 6-month periods: (a) the COVID-19 pandemic peak and (b) control period. Secondly, we compared the incidence of interstitial pneumonia on [18F]-FDG PET/CT and epidemiological data from the regional registry o...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Setti L,Bonacina M,Meroni R,Kirienko M,Galli F,Dalto SC,Erba PA,Bombardieri E

更新日期：2020-09-09 00:00:00

abstract：PURPOSE:In the era of precision medicine, patient-specific dose calculation using Monte Carlo (MC) simulations is deemed the gold standard technique for risk-benefit analysis of radiation hazards and correlation with patient outcome. Hence, we propose a novel method to perform whole-body personalized organ-level dosime...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Akhavanallaf A,Shiri I,Arabi H,Zaidi H

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:The aim of this series of cases is to show the aspects of ventilation/perfusion single-photon emission computed tomography combined with computed tomography (V/Q SPECT/CT) in patients hospitalized for COVID-19 pneumonia, with the worsening of respiratory symptoms raising the suspicion of a pulmonary embolism. P...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Cobes N,Guernou M,Lussato D,Queneau M,Songy B,Bonardel G,Grellier JF

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To evaluate the sensitivity and specificity of PET/CT findings in PMR and generate a diagnostic algorithm utilizing a minimum number of musculoskeletal sites. METHODS:Steroid-naïve patients with newly diagnosed PMR (2012 EULAR/ACR classification criteria) were prospectively recruited to undergo whole-body 18F-...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Owen CE,Poon AMT,Yang V,McMaster C,Lee ST,Liew DFL,Leung JL,Scott AM,Buchanan RRC

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:The purpose of this study was to compare dynamic 18F-FGln PET/CT images of healthy subjects and cancer patients and explore the best imaging phase for different cancers. METHODS:Thirteen healthy volunteers and 31 cancer patients separately underwent 18F-FGln and 18F-FDG PET/CT scans within 1 week. The distribu...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Xu X,Zhu H,Liu F,Zhang Y,Yang J,Zhang L,Xie Q,Zhu L,Li N,Kung HF,Yang Z

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:The serotonin transporter (SERT) is a biochemical marker for monoaminergic signaling in brain and has been suggested to be involved inthe pathophysiology of Parkinson's disease (PD). The aim of this PET study was to examine SERT availability in relevant brain regions in early stages ofnon-depressed PD patients....

journal_title：European journal of nuclear medicine and molecular imaging

authors： Fazio P,Ferreira D,Svenningsson P,Halldin C,Farde L,Westman E,Varrone A

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:We aimed to investigate the diagnostic power of 68Ga-PSMA PET/CT in the detection of metastatic spread of newly diagnosed PCa, and evaluate the relationship with modified D'Amico risk classification. METHODS:We evaluated newly diagnosed PCa patients who underwent 68Ga-PSMA PET/CT prior to therapy. All images w...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Simsek DH,Sanli Y,Engin MN,Erdem S,Sanli O

更新日期：2020-08-13 00:00:00

abstract：PURPOSE:To quantify the severity of 2019 novel coronavirus disease (COVID-19) on chest CT and to determine its relationship with laboratory parameters. METHODS:Patients with real-time fluorescence polymerase chain reaction (RT-PCR)-confirmed COVID-19 between January 01 and February 18, 2020, were included in this stud...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Zhang B,Zhang J,Chen H,Chen L,Chen Q,Li M,Chen Z,You J,Yang K,Zhang S

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:The aim of this feasibility study was to use slice selective learning using a Generative Adversarial Network for external validation. We aimed to build a model less sensitive to PET imaging acquisition environment, since differences in environments negatively influence network performance. To investigate the sl...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kim HW,Lee HE,Lee S,Oh KT,Yun M,Yoo SK

更新日期：2020-08-01 00:00:00

abstract：:After publication of this article we received a request from Dr. Jong Kyun Lee to have his name removed from the author list as he felt he did not fully meet the authorship criteria. The original version of this article was inadvertently published with an incorrect inclusion period of study. ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Lim CH,Cho YS,Choi JY,Lee KH,Min JH,Hyun SH

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:The aim of this short communication is to outline our experience in policies and processes of a nuclear medicine service during the COVID-19 outbreak in Singapore. METHODS:We describe the key considerations of policies and processes that have been implemented in our nuclear medicine service since the first cas...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Lam WW,Loke KS,Wong WY,Ng DC

更新日期：2020-07-01 00:00:00