The prognostic value of 18F-FDG PET/CT prior to liver transplantation for nonresectable colorectal liver metastases.

Abstract:

PURPOSE:The main objective of this study was to evaluate the prognostic value of volumetric and metabolic information derivied from F-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) in combination with computed tomography (CT) prior to liver transplantation (LT) in patients with nonresectable colorectal liver metastases (CLM). Due to scarcity of liver grafts, prognostic information enabling selection of candidates who will gain the highest survival after LT is of vital importance. 18F-FDG PET/CT was a part of the preoperative study protocol. Patients without evidence of extrahepatic malignant disease on 18F-FDG PET/CT who also fulfilled all the other inclusion criteria underwent LT. METHODS:The preoperative 18F-FDG PET/CT examinations of all patients included in the SECA (secondary cancer) study were retrospectively assessed. Maximum, mean and peak standardized uptake values (SUVmax, SUVmean and SUVpeak), tumor to background (T/B) ratio, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were measured and calculated for all liver metastases. Total MTV and TLG were calculated for each patient. Cut-off values were determined for each of these parameters by using receiver operating characteristic (ROC) analysis dividing the patients into two groups. One, three and five-year overall survival (OS) and disease free survival (DFS) for patients over and under the cut-off value were compared by using the Kaplan-Meier method and log rank test. RESULTS:Twenty-three patients underwent LT in the SECA study. Total MTV and TLG under the cut-off values were significantly correlated to improved OS at three and five years (p = 0.027 and 0.026) and DFS (p = 0.01). One, three and five-year OS and DFS were not significantly related to SUVmax, SUVmean, SUVpeak or T/B-ratio. CONCLUSION:Total MTV and TLG from 18F FDG PET/CT prior to LT for nonresectable CLM were significantly correlated to improved three and five-year OS and DFS and can potentially improve the patient selection for LT.

authors

Grut H,Dueland S,Line PD,Revheim ME

doi

10.1007/s00259-017-3843-9

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

218-225

issue

2

eissn

1619-7070

issn

1619-7089

pii

10.1007/s00259-017-3843-9

journal_volume

45

pub_type

杂志文章
  • Promising potential of [177Lu]Lu-DOTA-folate to enhance tumor response to immunotherapy-a preclinical study using a syngeneic breast cancer model.

    abstract:PURPOSE:It was previously demonstrated that radiation effects can enhance the therapy outcome of immune checkpoint inhibitors. In this study, a syngeneic breast tumor mouse model was used to investigate the effect of [177Lu]Lu-DOTA-folate as an immune stimulus to enhance anti-CTLA-4 immunotherapy. METHODS:In vitro and...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-020-05054-9

    authors: Guzik P,Siwowska K,Fang HY,Cohrs S,Bernhardt P,Schibli R,Müller C

    更新日期:2020-10-19 00:00:00

  • Standardization of metaiodobenzylguanidine heart to mediastinum ratio using a calibration phantom: effects of correction on normal databases and a multicentre study.

    abstract:PURPOSE:This study was performed to demonstrate that the results obtained with a calibration phantom could be used as a tool for standardizing measurement of heart to mediastinum (H/M) ratio in cardiac metaiodobenzylguanidine (MIBG) imaging. METHODS:Images of the phantom containing (123)I-MIBG were acquired on the cam...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00259-011-1963-1

    authors: Nakajima K,Okuda K,Matsuo S,Yoshita M,Taki J,Yamada M,Kinuya S

    更新日期:2012-01-01 00:00:00

  • Impact of aging on cardiac sympathetic innervation measured by 123I-mIBG imaging in patients with systolic heart failure.

    abstract:PURPOSE:Sympathetic nervous system (SNS) hyperactivity is a salient characteristic of chronic heart failure (HF) and contributes to the progression of the disease. Iodine-123 meta-iodobenzylguanidine (123I-mIBG) imaging has been successfully used to assess cardiac SNS activity in HF patients and to predict prognosis. I...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-016-3432-3

    authors: Rengo G,Pagano G,Vitale DF,Formisano R,Komici K,Petraglia L,Parisi V,Femminella GD,de Lucia C,Paolillo S,Cannavo A,Attena E,Pellegrino T,Dellegrottaglie S,Memmi A,Trimarco B,Cuocolo A,Filardi PP,Leosco D,Ferrara N

    更新日期:2016-12-01 00:00:00

  • Radiotherapy boost in patients with hypoxic lesions identified by 18F-FMISO PET/CT in non-small-cell lung carcinoma: can we expect a better survival outcome without toxicity? [RTEP5 long-term follow-up].

    abstract:PURPOSE:Chemoradiotherapy is the reference curative-intent treatment for nonresectable locally advanced non-small-cell lung carcinoma (NSCLC), with unsatisfactory survival, partially due to radiation resistance in hypoxic tissues. The objective was to update survival and toxicity at 3 years following radiotherapy boost...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00259-019-04285-9

    authors: Vera P,Mihailescu SD,Lequesne J,Modzelewski R,Bohn P,Hapdey S,Pépin LF,Dubray B,Chaumet-Riffaud P,Decazes P,Thureau S,all investigators of RTEP5 study (list in annexe).

    更新日期:2019-07-01 00:00:00

  • Investigation into the mechanisms of vagus nerve stimulation for the treatment of intractable epilepsy, using 99mTc-HMPAO SPET brain images.

    abstract::Vagus nerve stimulation (VNS) has gained recognition as a treatment for refractory epilepsies where surgical treatment is not possible. While it appears that this treatment is effective in some patients, the mechanism of action is not clearly understood. The purpose of this study was to clarify findings of other posit...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-002-1026-8

    authors: Barnes A,Duncan R,Chisholm JA,Lindsay K,Patterson J,Wyper D

    更新日期:2003-02-01 00:00:00

  • Prognostic value of interim FDG PET/CT in Hodgkin's lymphoma patients treated with interim response-adapted strategy: comparison of International Harmonization Project (IHP), Gallamini and London criteria.

    abstract:PURPOSE:Interim 2-[(18)F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) has shown to be an accurate predictor of prognosis in Hodgkin's lymphoma (HL). However, FDG PET response criteria are a matter of ongoing debate. The aim of this study was to confirm the prognostic value of interim PET/CT in HL pat...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-011-1741-0

    authors: Le Roux PY,Gastinne T,Le Gouill S,Nowak E,Bodet-Milin C,Querellou S,Mahe B,Dubruille V,Blin N,Salaun PY,Bodere-Kraeber F

    更新日期:2011-06-01 00:00:00

  • Abnormal pattern of brain glucose metabolism in Parkinson's disease: replication in three European cohorts.

    abstract:RATIONALE:In Parkinson's disease (PD), spatial covariance analysis of 18F-FDG PET data has consistently revealed a characteristic PD-related brain pattern (PDRP). By quantifying PDRP expression on a scan-by-scan basis, this technique allows objective assessment of disease activity in individual subjects. We provide a f...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-019-04570-7

    authors: Meles SK,Renken RJ,Pagani M,Teune LK,Arnaldi D,Morbelli S,Nobili F,van Laar T,Obeso JA,Rodríguez-Oroz MC,Leenders KL

    更新日期:2020-02-01 00:00:00

  • Effect of attenuation correction on the interpretation of 99mTc-sestamibi myocardial perfusion scintigraphy: the impact of 1 year's experience.

    abstract::The aim of this study was to determine the yield of attenuation correction in myocardial perfusion imaging (MPI), before and after a 1-year experience period. In 48 consecutive patients referred for MPI, both non-corrected (NC) and attenuation-corrected (AC) images were analysed by three independent readers shortly af...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-003-1265-3

    authors: Slart RH,Que TH,van Veldhuisen DJ,Poot L,Blanksma PK,Piers DA,Jager PL

    更新日期:2003-11-01 00:00:00

  • PET hypoxia imaging with FAZA: reproducibility at baseline and during fractionated radiotherapy in tumour-bearing mice.

    abstract:PURPOSE:Tumour hypoxia is linked to treatment resistance. Positron emission tomography (PET) using hypoxia tracers such as fluoroazomycin arabinoside (FAZA) may allow identification of patients with hypoxic tumours and the monitoring of the efficacy of hypoxia-targeting treatment. Since hypoxia PET is characterized by ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-012-2258-x

    authors: Busk M,Mortensen LS,Nordsmark M,Overgaard J,Jakobsen S,Hansen KV,Theil J,Kallehauge JF,D'Andrea FP,Steiniche T,Horsman MR

    更新日期:2013-01-01 00:00:00

  • Comparison of image quality and lesion detection between digital and analog PET/CT.

    abstract:OBJECTIVE:The purpose of this study was to compare image quality and lesion detection capability between a digital and an analog PET/CT system in oncological patients. MATERIALS AND METHODS:One hundred oncological patients (62 men, 38 women; mean age of 65 ± 12 years) were prospectively included from January-June 2018...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-019-4260-z

    authors: López-Mora DA,Flotats A,Fuentes-Ocampo F,Camacho V,Fernández A,Ruiz A,Duch J,Sizova M,Domènech A,Estorch M,Carrió I

    更新日期:2019-06-01 00:00:00

  • Dose-response relationship in cyclophosphamide-treated B-cell lymphoma xenografts monitored with [18F]FDG PET.

    abstract:PURPOSE:Although [(18)F]FDG PET can measure therapy response sooner and more accurately than morphological imaging techniques, there is still some debate as to whether [(18)F]FDG uptake really reflects changes in the viable cell fraction. In this study changes in [(18)F]FDG uptake were investigated in a lymphoma model ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-010-1479-0

    authors: Brepoels L,De Saint-Hubert M,Stroobants S,Verhoef G,Balzarini J,Mortelmans L,Mottaghy FM

    更新日期:2010-08-01 00:00:00

  • In vitro experimental (211)At-anti-CD33 antibody therapy of leukaemia cells overcomes cellular resistance seen in vivo against gemtuzumab ozogamicin.

    abstract:PURPOSE:Monoclonal anti-CD33 antibodies conjugated with toxic calicheamicin derivative (gemtuzumab ozogamicin, GO) are a novel therapy option for acute myeloid leukaemia (AML). Key prognostic factors for patients with AML are high CD33 expression on the leukaemic cells and the ability to overcome mechanisms of resistan...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-009-1356-x

    authors: Petrich T,Korkmaz Z,Krull D,Frömke C,Meyer GJ,Knapp WH

    更新日期:2010-05-01 00:00:00

  • The impact of image fusion in resolving discrepant findings between FDG-PET and MRI/CT in patients with gynaecological cancers.

    abstract::This study was performed to prospectively investigate the impact of image fusion in resolving discrepant findings between fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) or X-ray computed tomography (CT) in patients with gynaecological cancers. Discrepant find...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-003-1300-4

    authors: Tsai CC,Tsai CS,Ng KK,Lai CH,Hsueh S,Kao PF,Chang TC,Hong JH,Yen TC

    更新日期:2003-12-01 00:00:00

  • Oesophageal scintigraphy for the investigation of dysphagia: in ans out of favour - underused when available.

    abstract::Oesophageal scintigraphy has been used for more than 25 years and allows quantifiable, safe, rapid, non-invasive and well-tolerated assessment of oesophageal transit time and function. As technology improves, more complex image analysis is becoming possible. Many studies have addressed its usefulness in assessing oeso...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,评审

    doi:10.1007/s00259-002-0826-1

    authors: Stacey B,Patel P

    更新日期:2002-09-01 00:00:00

  • Functional implications of hippocampal degeneration in early Alzheimer's disease: a combined DTI and PET study.

    abstract:PURPOSE:Hypometabolism of the posterior cingulate cortex (PCC) in early Alzheimer's disease (AD) is thought to arise in part due to AD-specific neuronal damage to the hippocampal formation. Here, we explored the association between microstructural alterations within the hippocampus and whole-brain glucose metabolism in...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-011-1882-1

    authors: Yakushev I,Schreckenberger M,Müller MJ,Schermuly I,Cumming P,Stoeter P,Gerhard A,Fellgiebel A

    更新日期:2011-12-01 00:00:00

  • PET/CT-guided biopsies of metabolically active bone lesions: applications and clinical impact.

    abstract:PURPOSE:In a minority of cases a definite diagnosis and stage grouping in cancer patients is not possible based on the imaging information of PET/CT. We report our experience with percutaneous PET/CT-guided bone biopsies to histologically verify the aetiology of hypermetabolic bone lesions. METHODS:We retrospectively ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-010-1524-z

    authors: Klaeser B,Wiskirchen J,Wartenberg J,Weitzel T,Schmid RA,Mueller MD,Krause T

    更新日期:2010-11-01 00:00:00

  • Presynaptic dopamine depletion determines the timing of levodopa-induced dyskinesia onset in Parkinson's disease.

    abstract:PURPOSE:Reduced presynaptic dopaminergic activity plays an important role in the development of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD). In this study, we investigated whether dopaminergic function in the nigrostriatal system is associated with the timing of LID onset. METHODS:From among 412 drug...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-017-3844-8

    authors: Yoo HS,Chung SJ,Chung SJ,Moon H,Oh JS,Kim JS,Hong JY,Ye BS,Sohn YH,Lee PH

    更新日期:2018-03-01 00:00:00

  • Regional interaction between myocardial sympathetic denervation, contractile dysfunction, and fibrosis in heart failure with preserved ejection fraction: 11C-hydroxyephedrine PET study.

    abstract:PURPOSE:This investigation aimed to identify significant predictors of regional sympathetic denervation quantified by 11C-hydroxyephedrine (HED) positron emission tomography (PET) in patients with heart failure with preserved left ventricular ejection fraction (HFpEF). METHODS:Included in the study were 34 patients (a...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-017-3760-y

    authors: Aikawa T,Naya M,Obara M,Oyama-Manabe N,Manabe O,Magota K,Ito YM,Katoh C,Tamaki N

    更新日期:2017-10-01 00:00:00

  • Altered serotonin transporter availability in patients with multiple sclerosis.

    abstract:PURPOSE:Modulation of the immune system by the CNS may involve serotonergic regulation via the brain serotonin transporters (SERT). This regulation may be disturbed in patients with CNS disorders including multiple sclerosis (MS). Central serotonergic mechanisms have not been investigated in MS by in vivo imaging. The ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-013-2636-z

    authors: Hesse S,Moeller F,Petroff D,Lobsien D,Luthardt J,Regenthal R,Becker GA,Patt M,Thomae E,Seese A,Meyer PM,Bergh FT,Sabri O

    更新日期:2014-05-01 00:00:00

  • Ictal brain SPET during seizures pharmacologically provoked with pentylenetetrazol: a new diagnostic procedure in drug-resistant epileptic patients.

    abstract::Functional brain imaging plays an important role in seizure focus localisation. However, truly ictal single-photon emission tomography (SPET) studies are not routinely performed owing to technical problems associated with the use of tracers and methodological and logistical difficulties. In this study we tried to reso...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-002-0879-1

    authors: Calcagni ML,Giordano A,Bruno I,Parbonetti G,Di Giuda D,De Rossi G,Troncone L,Colicchio G

    更新日期:2002-10-01 00:00:00

  • Imaging β-amyloid using [(18)F]flutemetamol positron emission tomography: from dosimetry to clinical diagnosis.

    abstract::In Alzheimer's disease (AD), the deposition of β-amyloid (Aβ) is hypothesized to result in a series of secondary neurodegenerative processes, leading ultimately to synaptic dysfunction and neuronal loss. Since the advent of the first Aβ-specific positron emission tomography (PET) ligand, (11)C-Pittsburgh compound B ([...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,评审

    doi:10.1007/s00259-015-3208-1

    authors: Heurling K,Leuzy A,Zimmer ER,Lubberink M,Nordberg A

    更新日期:2016-02-01 00:00:00

  • Preoperative [18F]FDG PET/CT maximum standardized uptake value predicts recurrence of uterine cervical cancer.

    abstract:PURPOSE:To determine if preoperative [(18)F]FDG-PET/CT imaging has prognostic significance in patients with uterine cervical cancer. METHODS:Patients with FIGO stage IB to IIA cervical cancer were imaged with integrated FDG PET/CT before radical surgery. The relationship between the maximum standardized uptake value (...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-010-1413-5

    authors: Chung HH,Nam BH,Kim JW,Kang KW,Park NH,Song YS,Chung JK,Kang SB

    更新日期:2010-08-01 00:00:00

  • Validation of the dual-table autoradiographic method to quantify two sequential rCBFs in a single SPET session with N-isopropyl-[123I] p-iodoamphetamine.

    abstract::We evaluated an autoradiographic (ARG) method to calculate regional cerebral blood flow (rCBF) sequentially before and after an acetazolamide (ACZ) challenge in a single session of single-photon emission tomography (SPET) with two injections of N-isopropyl-[(123)I] p-iodoamphetamine (IMP). The method uses a table look...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-003-1180-7

    authors: Nishizawa S,Iida H,Tsuchida T,Ito H,Konishi J,Yonekura Y

    更新日期:2003-07-01 00:00:00

  • Comparison of MRI, [18F]FDG PET/CT, and 99mTc-UBI 29-41 scintigraphy for postoperative spondylodiscitis-a prospective multicenter study.

    abstract:PURPOSE:Postoperative infection still constitutes an important complication of spine surgery, and the optimal imaging modality for diagnosing postoperative spine infection has not yet been established. The aim of this prospective multicenter study was to assess the diagnostic performance of three imaging modalities in ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-020-05109-x

    authors: Paez D,Sathekge MM,Douis H,Giammarile F,Fatima S,Dhal A,Puri SK,Erba PA,Lazzeri E,Ferrando R,Filho PA,Magboo VP,Morozova O,Núñez R,Pellet O,Mariani G

    更新日期:2020-11-18 00:00:00

  • Hypertension complicating 131I-meta-iodobenzylguanidine therapy for neuroblastoma.

    abstract:PURPOSE:Radiolabelled meta-iodobenzylguanidine (mIBG), used as targeted therapy for neuroblastoma, is known to have effects on blood pressure (BP). In this study we audited BP changes in patients receiving (131)I-mIBG therapy for neuroblastoma to identify BP-related adverse events (AE) and possible predictive factors. ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-011-2022-7

    authors: Kosmin MA,Bomanji JB,Cork NJ,Shankar A,Gaze MN

    更新日期:2012-04-01 00:00:00

  • [(11)C]TASP457, a novel PET ligand for histamine H3 receptors in human brain.

    abstract:PURPOSE:The histamine H3 receptors are presynaptic neuroreceptors that inhibit the release of histamine and other neurotransmitters. The receptors are considered a drug target for sleep disorders and neuropsychiatric disorders with cognitive decline. We developed a novel PET ligand for the H3 receptors, [(11)C]TASP0410...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-016-3332-6

    authors: Kimura Y,Seki C,Ikoma Y,Ichise M,Kawamura K,Takahata K,Moriguchi S,Nagashima T,Ishii T,Kitamura S,Niwa F,Endo H,Yamada M,Higuchi M,Zhang MR,Suhara T

    更新日期:2016-08-01 00:00:00

  • 68Ga-PSMA-11 PET/CT in recurrent prostate cancer: efficacy in different clinical stages of PSA failure after radical therapy.

    abstract:OBJECTIVES:The primary objective was the evaluation of Gallium 68 (68Ga)-prostate-specific membrane antigen (PSMA)-11 positron emission tomography/computed tomography (PET/CT) detection rate, for identifying the site of prostate cancer (PCa) relapse (local vs systemic), stratifying the population according to different...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-018-4189-7

    authors: Ceci F,Castellucci P,Graziani T,Farolfi A,Fonti C,Lodi F,Fanti S

    更新日期:2019-01-01 00:00:00

  • In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals.

    abstract:PURPOSE:In vivo quantification of radiopharmaceuticals has great potential as a tool in developing new drugs. We investigated the accuracy of in vivo quantification with multi-pinhole single-photon emission computed tomography (SPECT) in rats. METHODS:Fifteen male Lewis rats with different stages of renal dysfunction ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-006-0178-3

    authors: Forrer F,Valkema R,Bernard B,Schramm NU,Hoppin JW,Rolleman E,Krenning EP,de Jong M

    更新日期:2006-10-01 00:00:00

  • Dynamic PET/CT imaging of 18F-(2S, 4R)4-fluoroglutamine in healthy volunteers and oncological patients.

    abstract:PURPOSE:The purpose of this study was to compare dynamic 18F-FGln PET/CT images of healthy subjects and cancer patients and explore the best imaging phase for different cancers. METHODS:Thirteen healthy volunteers and 31 cancer patients separately underwent 18F-FGln and 18F-FDG PET/CT scans within 1 week. The distribu...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-019-04543-w

    authors: Xu X,Zhu H,Liu F,Zhang Y,Yang J,Zhang L,Xie Q,Zhu L,Li N,Kung HF,Yang Z

    更新日期:2020-09-01 00:00:00

  • Iodine deficiency in Europe and its consequences: an update.

    abstract::This paper updates the information on the prevalence of the disorders induced by iodine deficiency (IDD) in Europe. Thirty-two European countries were still affected by mild to severe iodine deficiency in the late 1990s. The most severely affected countries were in Eastern Europe, including Central Asia, but Western E...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,评审

    doi:10.1007/s00259-002-0812-7

    authors: Delange F

    更新日期:2002-08-01 00:00:00