In vitro experimental (211)At-anti-CD33 antibody therapy of leukaemia cells overcomes cellular resistance seen in vivo against gemtuzumab ozogamicin.

abstract：PURPOSE:The aim of this study was to investigate the influence of a computer-based decision support system (DSS) on performance and inter-observer variability of interpretations regarding ischaemia and infarction in myocardial perfusion scintigraphy (MPS). METHODS:Seven physicians independently interpreted 97 MPS stud...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Tägil K,Bondouy M,Chaborel JP,Djaballah W,Franken PR,Grandpierre S,Hesse B,Lomsky M,Marie PY,Poisson T,Edenbrandt L

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:To evaluate the predictive value of early and late residual (18)F-fluorodeoxyglucose (FDG) and (18)F-fluorothymidine (FLT) uptake using different SUV measurements in PET in patients with advanced non-small-cell lung cancer (NSCLC) treated with erlotinib. METHODS:We retrospectively reviewed data from 30 patient...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kobe C,Scheffler M,Holstein A,Zander T,Nogova L,Lammertsma AA,Boellaard R,Neumaier B,Ullrich RT,Dietlein M,Wolf J,Kahraman D

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:The objective of this article is to present a new method for the diagnosis of insulinoma with the use of [Lys(40)(Ahx-HYNIC-(99m)Tc/EDDA)NH2]-exendin-4. METHODS:Studies were performed in 11 patients with negative results of all available non-isotopic diagnostic methods (8 with symptoms of insulinoma, 2 with ma...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sowa-Staszczak A,Pach D,Mikołajczak R,Mäcke H,Jabrocka-Hybel A,Stefańska A,Tomaszuk M,Janota B,Gilis-Januszewska A,Małecki M,Kamiński G,Kowalska A,Kulig J,Matyja A,Osuch C,Hubalewska-Dydejczyk A

更新日期：2013-04-01 00:00:00

abstract：:Nuclear medicine has a central role in the diagnosis, staging, response assessment and long-term follow-up of neuroblastoma, the most common solid extracranial tumour in children. These EANM guidelines include updated information on 123I-mIBG, the most common study in nuclear medicine for the evaluation of neuroblasto...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Bar-Sever Z,Biassoni L,Shulkin B,Kong G,Hofman MS,Lopci E,Manea I,Koziorowski J,Castellani R,Boubaker A,Lambert B,Pfluger T,Nadel H,Sharp S,Giammarile F

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) is commonly accepted as the gold standard to assess outcome after NAC in breast cancer patients. 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) has unique value in tumor staging, predicting prognosis, and eval...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Li P,Wang X,Xu C,Liu C,Zheng C,Fulham MJ,Feng D,Wang L,Song S,Huang G

更新日期：2020-05-01 00:00:00

abstract：PURPOSE:Although polyphosphonates (PPs) were introduced as bone imaging agents in nuclear medicine in the early 1970s, the mechanisms involved in their uptake still remain unclear. Suggested mechanisms range from mineral adsorption with disputed binding to the organic phase, over incorporation into the mineralisation p...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Toegel S,Hoffmann O,Wadsak W,Ettlinger D,Mien LK,Wiesner K,Nguemo J,Viernstein H,Kletter K,Dudczak R,Mitterhauser M

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:The effect of various doses of methylphenidate on the binding of [(123)I]iodobenzamide ([(123)I]IBZM) to the rat D(2) receptor was assessed using small animal SPECT. METHODS:D(2) receptor binding was measured at baseline and after pretreatment with various doses of methylphenidate. For baseline and methylpheni...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nikolaus S,Antke C,Beu M,Kley K,Wirrwar A,Huston JP,Müller HW

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:We previously reported in a small series of patients that (99m)Tc-3,3-diphosphono-1,2-propanodicarboxylic acid ((99m)Tc-DPD) scintigraphy tested positive in transthyretin-related (TTR) (both mutant and wild-type) but not in primary (AL) amyloidotic cardiomyopathy (AC). We extended our study to a larger cohort o...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Rapezzi C,Quarta CC,Guidalotti PL,Longhi S,Pettinato C,Leone O,Ferlini A,Salvi F,Gallo P,Gagliardi C,Branzi A

更新日期：2011-03-01 00:00:00

abstract：INTRODUCTION:Somatostatin receptor imaging with PET is the standard of care for patients with a neuroendocrine tumour (NET). Since therapy and imaging with somatostatin analogues utilize the same receptor, current guidelines recommend withdrawing long-acting somatostatin analogues for 3-4 weeks prior to somatostatin re...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Aalbersberg EA,de Wit-van der Veen BJ,Versleijen MWJ,Saveur LJ,Valk GD,Tesselaar MET,Stokkel MPM

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:The molecular imaging of tumour neoangiogenesis currently represents a major field of research for the diagnostic and treatment strategy of solid tumours. Endothelial cells from tumour neovessels overexpress the alpha(v)beta(3) integrin, which selectively binds to Arg-Gly-Asp (RGD)-containing peptides. We evalu...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sancey L,Ardisson V,Riou LM,Ahmadi M,Marti-Batlle D,Boturyn D,Dumy P,Fagret D,Ghezzi C,Vuillez JP

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:To determine whether [18F]FDG PET/CT-derived radiomic features alone or in combination with clinical, laboratory and biological parameters are predictive of 2-year progression-free survival (PFS) in patients with mantle cell lymphoma (MCL), and whether they enable outcome prognostication. METHODS:Included in t...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Mayerhoefer ME,Riedl CC,Kumar A,Gibbs P,Weber M,Tal I,Schilksy J,Schöder H

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:The histamine H3 receptors are presynaptic neuroreceptors that inhibit the release of histamine and other neurotransmitters. The receptors are considered a drug target for sleep disorders and neuropsychiatric disorders with cognitive decline. We developed a novel PET ligand for the H3 receptors, [(11)C]TASP0410...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kimura Y,Seki C,Ikoma Y,Ichise M,Kawamura K,Takahata K,Moriguchi S,Nagashima T,Ishii T,Kitamura S,Niwa F,Endo H,Yamada M,Higuchi M,Zhang MR,Suhara T

更新日期：2016-08-01 00:00:00

abstract：:The human cardiac nervous system consists of a sympathetic and a parasympathetic branch with (-)-norepinephrine and acetylcholine as the respective endogenous neurotransmitters. Dysfunction of the cardiac nervous system is implicated in various types of cardiac disease, such as heart failure, myocardial infarction and...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Langer O,Halldin C

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:The aim of this study was to develop a methodology for the comparison of pathology specimens after prostatectomy (post-S) with PET images obtained before surgery (pre-S). This method was used to evaluate the merit of (11)C-choline PET/CT for delineation of gross tumour volume (GTV) in prostate cancer (PC). MET...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Grosu AL,Weirich G,Wendl C,Prokic V,Kirste S,Geinitz H,Souvatzoglou M,Gschwend JE,Schwaiger M,Molls M,Weber WA,Treiber U,Krause BJ

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Bone metastases are responsible for most of the morbidity associated with hormone-refractory prostate cancer (HRPC). 153Sm-ethylenediaminetetramethylene phosphonate (153Sm-EDTMP) has been approved for palliation of painful skeletal metastases. We retrospectively investigated the possible synergistic effect o...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ricci S,Boni G,Pastina I,Genovesi D,Cianci C,Chiacchio S,Orlandini C,Grosso M,Alsharif A,Chioni A,Di Donato S,Francesca F,Selli C,Rubello D,Mariani G

更新日期：2007-07-01 00:00:00

abstract：AIM:This study assessed the ability of visual and quantitative 124-iodine positron emission tomography ((124)I PET) data to detect disseminated iodine-avid lung metastases (DILM) of differentiated thyroid cancer (DTC). MATERIALS AND METHODS:Using "post-therapy" 131-iodine ((131)I) whole-body scintigraphy (TxWBS) and t...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Freudenberg LS,Jentzen W,Müller SP,Bockisch A

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans. METHODS:PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patient outcomes to 12 mo...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Scott AM,Gunawardana DH,Wong J,Kirkwood I,Hicks RJ,Ho Shon I,Ramshaw JE,Robins P

更新日期：2009-03-01 00:00:00

abstract：:[Yttrium-90-DOTA-Tyr(3)]-octreotide (DOTATOC) and [(177)Lu-DOTA-Tyr(3)-Thr(8)]-octreotide (DOTATATE) are used for peptide receptor-mediated radionuclide therapy (PRMRT) in neuroendocrine tumours. No human data comparing these two compounds are available so far. We used (111)In as a surrogate for (90)Y and (177)Lu and ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Forrer F,Uusijärvi H,Waldherr C,Cremonesi M,Bernhardt P,Mueller-Brand J,Maecke HR

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:This study evaluated the usefulness of the maximum standardized uptake value (SUVmax) as a measure of histologic response to neoadjuvant chemotherapy in patients with extremity osteosarcoma. The correlation between [(18) F]FDG PET SUVmax values and histologic response to preoperative chemotherapy was also asses...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kong CB,Byun BH,Lim I,Choi CW,Lim SM,Song WS,Cho WH,Jeon DG,Koh JS,Yoo JY,Lee SY

更新日期：2013-05-01 00:00:00

abstract：PURPOSE:Preclinical, or asymptomatic, Alzheimer's disease (AD) refers to the presence of positive AD biomarkers in the absence of cognitive deficits. This research concept is being applied to define target populations for clinical drug development. In a prospective community-recruited cohort of cognitively intact older...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Adamczuk K,Schaeverbeke J,Nelissen N,Neyens V,Vandenbulcke M,Goffin K,Lilja J,Hilven K,Dupont P,Van Laere K,Vandenberghe R

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Despite modern CT systems and expert evaluators, the diagnostic performance of coronary CT angiography is limited by overestimation of vessel stenosis which reduces the positive predictive value (PPV) of the test. The aim of this study was to evaluate the performance of combined cardiac PET/64-detector CT angio...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Groves AM,Speechly-Dick ME,Kayani I,Pugliese F,Endozo R,McEwan J,Menezes LJ,Habib SB,Prvulovich E,Ell PJ

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:Enlarged perivascular spaces in the centrum semiovale (CSO-EPVS) have been linked to cerebral amyloid angiopathy (CAA). To get insight into the underlying mechanisms of this association, we investigated the relationship between amyloid-β deposition assessed by 18F-florbetapir PET and CSO-EPVS in patients with a...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Raposo N,Planton M,Payoux P,Péran P,Albucher JF,Calviere L,Viguier A,Rousseau V,Hitzel A,Chollet F,Olivot JM,Bonneville F,Pariente J

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:To study the feasibility of the in vivo [18F]-DPA-714 TSPO positron emission tomography (PET) to detect glial activation in a rat model of progressive parkinsonism induced by viral-mediated overexpression of A53T mutated human α-synuclein (hα-syn) in the substantia nigra pars compacta (SNpc). METHODS:We conduc...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Rodríguez-Chinchilla T,Quiroga-Varela A,Molinet-Dronda F,Belloso-Iguerategui A,Merino-Galan L,Jimenez-Urbieta H,Gago B,Rodriguez-Oroz MC

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:Neuroendocrine diseases are a heterogeneous group of entities with the ability to take up amine precursors, such as L-DOPA, and convert them into biogenic amines, such as dopamine. Congenital hyperinsulinism of infancy (HI) is a neuroendocrine disease secondary to either focal adenomatous hyperplasia or a diffu...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ribeiro MJ,Boddaert N,Bellanné-Chantelot C,Bourgeois S,Valayannopoulos V,Delzescaux T,Jaubert F,Nihoul-Fékété C,Brunelle F,De Lonlay P

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:Functional activation protocols are widely applied for the study of brain-cognition relations. Only few take advantage of the intrinsic characteristics of SPECT, particularly those allowing cognitive assessment outside of the camera, in settings close to the standard clinical or laboratory ones. The purpose of ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ludwig C,Chicherio C,Terraneo L,Magistretti P,de Ribaupierre A,Slosman D

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:To assess the relationship between serum thyroglobulin (Tg) levels, Tg doubling time (Tg-DT) and the diagnostic performance of (18)F-FDG PET/CT in detecting recurrences of (131)I-negative differentiated thyroid carcinoma (DTC). METHODS:Included in the present study were 102 patients with DTC. All patients were...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Giovanella L,Trimboli P,Verburg FA,Treglia G,Piccardo A,Foppiani L,Ceriani L

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:Continuous bed motion has recently been introduced for whole-body PET/CT, and represents a paradigm shift towards individualized and flexible acquisition without the limitations of bed position-based planning. Increased patient comfort due to lack of abrupt table position changes may be another albeit still unp...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Schatka I,Weiberg D,Reichelt S,Owsianski-Hille N,Derlin T,Berding G,Bengel FM

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:The objective of this study was to evaluate whether 68Ga-PSMA PET/CT whole-body tumor burden (PSMAwbtb) is associated with clinical parameters and laboratory parameters in prostate cancer patients. METHODS:We retrospectively evaluated prostate cancer patients submitted to PSMA PET/CT for primary staging purpos...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Santos A,Mattiolli A,Carvalheira JB,Ferreira U,Camacho M,Silva C,Costa F,Matheus W,Lima M,Etchebehere E

更新日期：2021-02-01 00:00:00

abstract：:Cardiac sarcoidosis (CS) is a rare and potentially life-threatening disease that causes conduction disturbance, systolic dysfunction, and most notably sudden cardiac death. Accurate diagnosis of CS is thus mandatory; however, a reliable approach that enables diagnosis of CS with high sensitivity and specificity has ye...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ohira H,Tsujino I,Yoshinaga K

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:Nitroglycerin (NTG) is a vasodilating drug, which increases tumor blood flow and consequently decreases hypoxia. Therefore, changes in [18F] fluorodeoxyglucose positron emission tomography ([18F]FDG PET) uptake pattern may occur. In this analysis, we investigated the feasibility of [18F]FDG PET for response ass...

journal_title：European journal of nuclear medicine and molecular imaging

authors： de Jong EE,van Elmpt W,Leijenaar RT,Hoekstra OS,Groen HJ,Smit EF,Boellaard R,van der Noort V,Troost EG,Lambin P,Dingemans AC

更新日期：2017-01-01 00:00:00