In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals.

abstract：:Dynamic PET (dPET) studies have been used until now primarily within research purposes. Although it is generally accepted that the information provided by dPET is superior to that of conventional static PET acquisitions acquired usually 60 min post injection of the radiotracer, the duration of dynamic protocols, the l...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Dimitrakopoulou-Strauss A,Pan L,Sachpekidis C

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:The study serves to optimise conditions for multi-pinhole SPECT small animal imaging of (123)I- and (99m)Tc-labelled radiopharmaceuticals with different distributions in murine heart and brain and to investigate detection and dose range thresholds for verification of differences in tracer uptake. METHODS:A Tri...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Pissarek M,Meyer-Kirchrath J,Hohlfeld T,Vollmar S,Oros-Peusquens AM,Flögel U,Jacoby C,Krügel U,Schramm N

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:We developed and tested a single acquisition rest (99m)Tc-sestamibi/stress (201)Tl dual isotope protocol (SDI) with the intention of improving the clinical workflow and patient comfort of myocardial perfusion single photon emission computed tomography (SPECT). METHODS:The technical feasibility of SDI was evalu...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Dey T,Backus BE,Romijn RL,Wieczorek H,Verzijlbergen JF

更新日期：2014-03-01 00:00:00

abstract：:In Alzheimer's disease (AD), the deposition of β-amyloid (Aβ) is hypothesized to result in a series of secondary neurodegenerative processes, leading ultimately to synaptic dysfunction and neuronal loss. Since the advent of the first Aβ-specific positron emission tomography (PET) ligand, (11)C-Pittsburgh compound B ([...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Heurling K,Leuzy A,Zimmer ER,Lubberink M,Nordberg A

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:To assess the binding of the PET tracer [18F]THK5351 in patients with different primary progressive aphasia (PPA) variants and its correlation with clinical deficits. The majority of patients with nonfluent variant (NFV) and logopenic variant (LV) PPA have underlying tauopathy of the frontotemporal lobar or Alz...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Schaeverbeke J,Evenepoel C,Declercq L,Gabel S,Meersmans K,Bruffaerts R,Adamczuk K,Dries E,Van Bouwel K,Sieben A,Pijnenburg Y,Peeters R,Bormans G,Van Laere K,Koole M,Dupont P,Vandenberghe R

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Increasing evidence supports the value of peptide receptor radionuclide therapy (PRRT) in patients with metastatic neuroendocrine tumours (NET), but there are limited data on its specific efficacy in NET of small intestinal (midgut) origin. This study aims to define the benefit of PRRT with (177)Lu-octreotate f...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sabet A,Dautzenberg K,Haslerud T,Aouf A,Sabet A,Simon B,Mayer K,Biersack HJ,Ezziddin S

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:In vivo Alzheimer's disease (AD) biomarkers for tau pathology are cerebrospinal fluid (CSF) phosphorylated tau (p-tau) and [18F]flortaucipir positron emission tomography (PET). Our aim was to assess associations between CSF p-tau with [18F]flortaucipir PET and the associations of both tau biomarkers with cognit...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Wolters EE,Ossenkoppele R,Verfaillie SCJ,Coomans EM,Timmers T,Visser D,Tuncel H,Golla SSV,Windhorst AD,Boellaard R,van der Flier WM,Teunissen CE,Scheltens P,van Berckel BNM

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:The purpose of this prospective study was to evaluate the usefulness of (18)F-fluorodeoxyglucose (FDG) and (11)C-choline positron emission tomography (PET)/computed tomography (CT) for detecting recurrences of advanced head and neck cancer after combined intra-arterial chemotherapy and radiotherapy. Additionall...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ito K,Yokoyama J,Kubota K,Morooka M,Shiibashi M,Matsuda H

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:Artificial neural networks (ANN) might help to diagnose coronary artery disease. This study aimed to determine whether the diagnostic accuracy of an ANN-based diagnostic system and conventional quantitation are comparable. METHODS:The ANN was trained to classify potentially abnormal areas as true or false base...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nakajima K,Kudo T,Nakata T,Kiso K,Kasai T,Taniguchi Y,Matsuo S,Momose M,Nakagawa M,Sarai M,Hida S,Tanaka H,Yokoyama K,Okuda K,Edenbrandt L

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:Hypometabolism of the posterior cingulate cortex (PCC) in early Alzheimer's disease (AD) is thought to arise in part due to AD-specific neuronal damage to the hippocampal formation. Here, we explored the association between microstructural alterations within the hippocampus and whole-brain glucose metabolism in...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Yakushev I,Schreckenberger M,Müller MJ,Schermuly I,Cumming P,Stoeter P,Gerhard A,Fellgiebel A

更新日期：2011-12-01 00:00:00

abstract：:The figure is missing. ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Paepegaey AC,Cottereau AS,Dohan A,Gaujoux S,Triller MF,Sibony M,Groussin L,Libé R

更新日期：2020-11-06 00:00:00

abstract：PURPOSE:The study aims to investigate the role of 18F-alfatide positron emission tomography/computed tomography (PET/CT) in predicting the short-term outcome of concurrent chemoradiotherapy (CCRT) in patients with advanced non-small cell lung cancer (NSCLC). METHODS:Eighteen patients with advanced NSCLC had undergone ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Luan X,Huang Y,Gao S,Sun X,Wang S,Ma L,Teng X,Lu H,Yu J,Yuan S

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:To review literature until November 2015 and reach a consensus on whether automatic semi-quantification of brain FDG-PET is useful in the clinical setting for neurodegenerative disorders. METHODS:A literature search was conducted in Medline, Embase, and Google Scholar. Papers were selected with a lower limit o...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nobili F,Festari C,Altomare D,Agosta F,Orini S,Van Laere K,Arbizu J,Bouwman F,Drzezga A,Nestor P,Walker Z,Boccardi M,EANM-EAN Task Force for the Prescription of FDG-PET for Dementing Neurodegenerative Disorders.

更新日期：2018-07-01 00:00:00

abstract：:The aims of this study were to assess the potential of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) for tumor grading in chondrosarcoma patients and to evaluate the role of standardized uptake value (SUV) as a parameter for prediction of patient outcome. FDG PET imaging was performed in 31 pat...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Brenner W,Conrad EU,Eary JF

更新日期：2004-02-01 00:00:00

abstract：PURPOSE:Radioembolisation is part of the multimodal treatment of hepatocellular carcinoma (HCC) at specialist liver centres. This study analysed the impact of prior treatment on tolerability and survival following radioembolisation. METHODS:This was a retrospective analysis of 325 consecutive patients with a confirmed...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sangro B,Maini CL,Ettorre GM,Cianni R,Golfieri R,Gasparini D,Ezziddin S,Paprottka PM,Fiore F,Van Buskirk M,Bilbao JI,Salvatori R,Giampalma E,Geatti O,Wilhelm K,Hoffmann RT,Izzo F,Iñarrairaegui M,Urigo C,Cappelli A,

更新日期：2018-09-01 00:00:00

abstract：PURPOSE/BACKGROUND:[18F]fluoroethylcholine (18FECH) has been shown to be a valuable PET-tracer in recurrent prostate cancer (PCa), but still has limited accuracy. RM2 is a gastrin-releasing peptide receptor (GRPr) antagonist that binds to GRPr on PCa cells. Recent studies suggest that GRPr imaging with PET/CT is a prom...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Wieser G,Popp I,Christian Rischke H,Drendel V,Grosu AL,Bartholomä M,Weber WA,Mansi R,Wetterauer U,Schultze-Seemann W,Meyer PT,Jilg CA

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:To determine whether [18F]FDG PET/CT-derived radiomic features alone or in combination with clinical, laboratory and biological parameters are predictive of 2-year progression-free survival (PFS) in patients with mantle cell lymphoma (MCL), and whether they enable outcome prognostication. METHODS:Included in t...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Mayerhoefer ME,Riedl CC,Kumar A,Gibbs P,Weber M,Tal I,Schilksy J,Schöder H

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:PSMA ligand imaging with hybrid PET/MRI scanners could be an integral part of the clinical routine in the future. However, the first study about this novel method revealed a severe photopenic artifact ("halo artifact") around the urinary bladder causing significantly reduced tumor visibility. The aim of this ev...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Afshar-Oromieh A,Wolf M,Haberkorn U,Kachelrieß M,Gnirs R,Kopka K,Schlemmer HP,Freitag MT

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:Overactivity of the multidrug efflux transporter P-glycoprotein (P-gp) at the blood-brain barrier (BBB) is believed to play an important role in resistance to central nervous system drug treatment. (R)-[(11)C]verapamil (VPM) PET can be used to measure the function of P-gp at the BBB, but low brain uptake of VPM...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kuntner C,Bankstahl JP,Bankstahl M,Stanek J,Wanek T,Stundner G,Karch R,Brauner R,Meier M,Ding X,Müller M,Löscher W,Langer O

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:To evaluate the relationship between coronary artery calcium (CAC) and coronary vasodilator function. METHODS:We evaluated 136 patients without known coronary artery disease (CAD) undergoing vasodilator stress (82)Rb PET/CT and CAC scoring who showed normal myocardial perfusion. The CAC score, resting and hype...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Curillova Z,Yaman BF,Dorbala S,Kwong RY,Sitek A,El Fakhri G,Anagnostopoulos C,Di Carli MF

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:Diabetic patients have a high risk for cardiovascular events. The role of myocardial perfusion imaging was investigated in asymptomatic diabetic patients to evaluate short-term prognosis in a Japanese population. METHODS:A total of 506 asymptomatic patients ≥ 50 years of age who had carotid artery maximum inti...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nakajima K,Yamasaki Y,Kusuoka H,Izumi T,Kashiwagi A,Kawamori R,Shimamoto K,Yamada N,Nishimura T

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:Radiolabelled somatostatin (SST) analogues have proven useful in diagnosing tumours positive for SST receptor (SSTR). As different subtypes of SSTR are expressed on the tumour cell surface, the choice of appropriate therapeutic SST analogue is crucial. We evaluated the SSTR status of thyroid cancer patients who...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Traub-Weidinger T,Putzer D,von Guggenberg E,Dobrozemsky G,Nilica B,Kendler D,Bale R,Virgolini IJ

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:To investigate whether (11)C-N-methylspiperone ((11)C-NMSP) microPET could be used for imaging neural stem cells (NSCs) transplantation in a rat model of traumatic brain injury. METHODS:NSCs were induced to express dopamine receptor type 2 (DRD(2)), then confirmed by RT-PCR, Western blotting and immunocytochem...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Zhang H,Zheng X,Yang X,Fang S,Shen G,Zhao C,Tian M

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:We evaluated the potential usefulness of [68Ga]Ga-DOTA-FAPI-04 positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various types of cancer, compared with [18F] FDG PET/CT. METHODS:A total of 75 patients with various types of cancer underwent contempo...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Chen H,Pang Y,Wu J,Zhao L,Hao B,Wu J,Wei J,Wu S,Zhao L,Luo Z,Lin X,Xie C,Sun L,Lin Q,Wu H

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:Familial adenomatous polyposis (FAP) is characterised by colonic and duodenal adenomatous polyps that carry a risk of malignant transformation. Malignant degeneration of duodenal adenomas is difficult to detect. We speculated that 2-((18)F)-fluoro-2-deoxy-D: -glucose positron emission tomography (FDG-PET) might...

journal_title：European journal of nuclear medicine and molecular imaging

authors： van Kouwen MC,Drenth JP,van Krieken JH,van Goor H,Friederich P,Oyen WJ,Nagengast FM

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:Recurrences are frequent in thyroid cancer patients and long-term follow-up is therefore necessary. We evaluated the yield of rhTSH stimulation in three groups of patients, classified according to the UICC/TNM risk stratification and the results of first follow-up testing. METHODS:The study population comprise...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Zanotti-Fregonara P,Khoury A,Duron F,Keller I,Christin-Maître S,Kiffel T,Toubert ME,Devaux JY,Hindié E

更新日期：2007-04-01 00:00:00

abstract：PURPOSE:To know whether mild cognitive impairment (MCI) patients will develop Alzheimer's disease (AD) dementia in very short time or remain stable is of crucial importance, also considering new experimental drugs usually tested within very short time frames. Here we combined cerebrospinal fluid (CSF) AD biomarkers and...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Santangelo R,Masserini F,Agosta F,Sala A,Caminiti SP,Cecchetti G,Caso F,Martinelli V,Pinto P,Passerini G,Perani D,Magnani G,Filippi M

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:In this study, kinetic parameters of the cellular proliferation tracer (18)F-3'-deoxy-3'-fluoro-L-thymidine (FLT) and the amino acid probe 3,4-dihydroxy-6-(18)F-fluoro-L-phenylalanine (FDOPA) were measured before and early after the start of therapy, and were used to predict the overall survival (OS) of patient...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Wardak M,Schiepers C,Cloughesy TF,Dahlbom M,Phelps ME,Huang SC

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:The aim of this study was to develop a methodology for the comparison of pathology specimens after prostatectomy (post-S) with PET images obtained before surgery (pre-S). This method was used to evaluate the merit of (11)C-choline PET/CT for delineation of gross tumour volume (GTV) in prostate cancer (PC). MET...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Grosu AL,Weirich G,Wendl C,Prokic V,Kirste S,Geinitz H,Souvatzoglou M,Gschwend JE,Schwaiger M,Molls M,Weber WA,Treiber U,Krause BJ

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Continuous bed motion has recently been introduced for whole-body PET/CT, and represents a paradigm shift towards individualized and flexible acquisition without the limitations of bed position-based planning. Increased patient comfort due to lack of abrupt table position changes may be another albeit still unp...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Schatka I,Weiberg D,Reichelt S,Owsianski-Hille N,Derlin T,Berding G,Bengel FM

更新日期：2016-04-01 00:00:00