Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.

Abstract:

PURPOSE:Overactivity of the multidrug efflux transporter P-glycoprotein (P-gp) at the blood-brain barrier (BBB) is believed to play an important role in resistance to central nervous system drug treatment. (R)-[(11)C]verapamil (VPM) PET can be used to measure the function of P-gp at the BBB, but low brain uptake of VPM hampers the mapping of regional differences in cerebral P-gp function and expression. The aim of this study was to evaluate the dose-response relationship of two potent P-gp inhibitors and to investigate if increased brain uptake of VPM mediated by P-gp inhibition can be used to assess regional differences in P-gp activity. METHODS:Two groups of Sprague-Dawley rats (n = 12) underwent single VPM PET scans at 120 min after administration of different doses of the P-gp inhibitors tariquidar and elacridar. In an additional six rats, paired VPM PET scans were performed before and after administration of 3 mg/kg tariquidar. RESULTS:Inhibitor administration resulted in an up to 11-fold increase in VPM brain distribution volumes (DV) with half-maximum effective dose (ED(50)) values of 3.0 +/- 0.2 and 1.2 +/- 0.1 mg/kg for tariquidar and elacridar, respectively. In paired PET scans, 3 mg/kg tariquidar resulted in regionally different enhancement of brain activity distribution, with lowest DV in cerebellum and highest DV in thalamus. CONCLUSION:Our data show that tariquidar and elacridar are able to increase VPM brain distribution in rat brain up to 11-fold over baseline at maximum effective doses, with elacridar being about three times more potent than tariquidar. Regional differences in tariquidar-induced modulation of VPM brain uptake point to regional differences in cerebral P-gp function and expression in rat brain.

authors

Kuntner C,Bankstahl JP,Bankstahl M,Stanek J,Wanek T,Stundner G,Karch R,Brauner R,Meier M,Ding X,Müller M,Löscher W,Langer O

doi

10.1007/s00259-009-1332-5

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

942-53

issue

5

eissn

1619-7070

issn

1619-7089

journal_volume

37

pub_type

杂志文章
  • Value of ¹³¹I SPECT/CT for the evaluation of differentiated thyroid cancer: a systematic review of the literature.

    abstract:PURPOSE:In the present study, we performed a systematic review of the current literature to assess the incremental value of (131)I single photon emission computed tomography (SPECT)/CT for the management of patients with differentiated thyroid cancer (DTC). METHODS:The search of PubMed/MEDLINE and EMBASE databases to ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,评审

    doi:10.1007/s00259-012-2310-x

    authors: Xue YL,Qiu ZL,Song HJ,Luo QY

    更新日期:2013-05-01 00:00:00

  • Bone scintigraphy predicts the risk of spinal cord compression in hormone-refractory prostate cancer.

    abstract::In prostate cancer, confirmation of metastatic involvement of the skeleton has traditionally been achieved by bone scintigraphy, although the widespread availability of prostate-specific antigen (PSA) measurements has tended to eliminate the need for this investigation. The potential of bone scintigraphy to predict sk...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-004-1479-z

    authors: Soerdjbalie-Maikoe V,Pelger RC,Lycklama à Nijeholt GA,Arndt JW,Zwinderman AH,Bril H,Papapoulos SE,Hamdy NA

    更新日期:2004-07-01 00:00:00

  • Predictive value of dopamine transporter SPECT imaging with [¹²³I]PE2I in patients with subtle parkinsonian symptoms.

    abstract:PURPOSE:To examine the diagnostic sensitivity and specificity of dopamine transporter SPECT imaging with a highly dopamine transporter selective radioligand. The study included consecutively enrolled, drug-naive patients with an average short history of parkinsonian motor symptoms, referred for diagnostic scanning. ME...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-011-1976-9

    authors: Ziebell M,Andersen BB,Thomsen G,Pinborg LH,Karlsborg M,Hasselbalch SG,Knudsen GM

    更新日期:2012-02-01 00:00:00

  • Brain metabolic patterns in patients with suspected non-Alzheimer's pathophysiology (SNAP) and Alzheimer's disease (AD): is [18F] FDG a specific biomarker in these patients?

    abstract:PURPOSE:The present study was conducted to compare the pattern of brain [18F] FDG uptake in suspected non-Alzheimer's pathophysiology (SNAP), AD, and healthy controls using 2-deoxy-2-[18F]fluoroglucose ([18F] FDG) positron emission tomography imaging. Cerebrospinal fluid (CSF) biomarkers amyloid-β1-42 peptide (Aβ1-42) ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-019-04379-4

    authors: Chiaravalloti A,Barbagallo G,Martorana A,Castellano AE,Ursini F,Schillaci O

    更新日期:2019-08-01 00:00:00

  • Assessment of poststress left ventricular ejection fraction by gated SPECT: comparison with equilibrium radionuclide angiocardiography.

    abstract:PURPOSE:We compared left ventricular (LV) ejection fraction obtained by gated SPECT with that obtained by equilibrium radionuclide angiocardiography in a large cohort of patients. METHODS:Within 1 week, 514 subjects with suspected or known coronary artery disease underwent same-day stress-rest (99m)Tc-sestamibi gated ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-009-1308-5

    authors: Acampa W,Caprio MG,Nicolai E,Liuzzi R,De Luca S,Capasso E,Luongo L,Petretta M,Cuocolo A

    更新日期:2010-02-01 00:00:00

  • Neuroradiological advances detect abnormal neuroanatomy underlying neuropsychological impairments: the power of PET imaging.

    abstract::Medical imaging has made a major contribution to cerebral dysfunction due to inherited diseases, as well as injuries sustained with modern living, such as car accidents, falling down, and work-related injuries. These injuries, up until the introduction of sensitive techniques such as positron emission tomography (PET)...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,收录出版

    doi:10.1007/s00259-013-2401-3

    authors: Hayempour BJ,Alavi A

    更新日期:2013-09-01 00:00:00

  • Quantification of temporal changes in calcium score in active atherosclerotic plaque in major vessels by 18F-sodium fluoride PET/CT.

    abstract:PURPOSE:Our aim was to assess whether 18F-NaF PET/CT is able to predict progression of the CT calcium score. METHODS:Between August 2007 and November 2015, 34 patients (18 women, 16 men; age, mean ± standard deviation, 57.5 ± 13.9 years; age range 19-78 years) with malignancy or orthopaedic disease were enrolled in th...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-017-3680-x

    authors: Ishiwata Y,Kaneta T,Nawata S,Hino-Shishikura A,Yoshida K,Inoue T

    更新日期:2017-08-01 00:00:00

  • PET hypoxia imaging with FAZA: reproducibility at baseline and during fractionated radiotherapy in tumour-bearing mice.

    abstract:PURPOSE:Tumour hypoxia is linked to treatment resistance. Positron emission tomography (PET) using hypoxia tracers such as fluoroazomycin arabinoside (FAZA) may allow identification of patients with hypoxic tumours and the monitoring of the efficacy of hypoxia-targeting treatment. Since hypoxia PET is characterized by ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-012-2258-x

    authors: Busk M,Mortensen LS,Nordsmark M,Overgaard J,Jakobsen S,Hansen KV,Theil J,Kallehauge JF,D'Andrea FP,Steiniche T,Horsman MR

    更新日期:2013-01-01 00:00:00

  • Clinical response assessment on DW-MRI compared with FDG-PET/CT after neoadjuvant chemoradiotherapy in patients with oesophageal cancer.

    abstract:PURPOSE:In about 30% of patients treated with neoadjuvant chemoradiotherapy (nCRT) followed by surgical resection for locally advanced oesophageal cancer no vital tumour is found in the resection specimen. Accurate clinical response assessment is critical if deferral from surgery is considered in complete responders. O...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-020-04917-5

    authors: Vollenbrock SE,Voncken FEM,Lambregts DMJ,Maas M,Donswijk ML,Vegt E,Ter Beek LC,van Dieren JM,van Sandick JW,Aleman BMP,Beets-Tan RGH,Bartels-Rutten A

    更新日期:2021-01-01 00:00:00

  • Development and validation of a direct-comparison method for cardiac (123)I-metaiodobenzylguanidine washout rates derived from late 3-hour and 4-hour imaging.

    abstract:PURPOSE:The washout rate (WR) has been used in (123)I-metaiodobenzylguanidine (MIBG) imaging to evaluate cardiac sympathetic innervation. However, WR varies depending on the time between the early and late MIBG scans. Late scans are performed at either 3 or 4 hours after injection of MIBG. The aim of this study was to ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-015-3173-8

    authors: Okuda K,Nakajima K,Sugino S,Kirihara Y,Matsuo S,Taki J,Hashimoto M,Kinuya S

    更新日期:2016-02-01 00:00:00

  • Comparison of (18)F-FLT PET and (18)F-FDG PET for preoperative staging in non-small cell lung cancer.

    abstract:PURPOSE:The nucleoside analog 3'-deoxy-3'-(18)F-fluorothymidine (FLT) has been introduced for imaging cell proliferation with positron emission tomography (PET). We prospectively compared the diagnostic efficacy of FLT PET with that of 2-deoxy-2-(18)F-fluoro-D-glucose (FDG) PET for the preoperative nodal and distant me...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-007-0613-0

    authors: Yamamoto Y,Nishiyama Y,Kimura N,Ishikawa S,Okuda M,Bandoh S,Kanaji N,Asakura M,Ohkawa M

    更新日期:2008-02-01 00:00:00

  • Long-term prognostic implications of myocardial perfusion imaging in octogenarians: an all-comer, cohort study.

    abstract:PURPOSE:Evaluation of the long-term prognostic value of myocardial perfusion imaging (MPI) in octogenarians. METHODS:Six hundred and twenty-nine octogenarians [51% previous myocardial infarction (MI) or revascularization] who underwent single-isotope MPI (78% 201Tl, 22% 99mTc-tetrofosmin) with exercise (38% Bruce, 2% ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-017-3739-8

    authors: Katsikis A,Theodorakos A,Manira V,Papaioannou S,Kolovou G,Voudris V,Koutelou M

    更新日期:2017-08-01 00:00:00

  • Memory-provoked rCBF-SPECT as a diagnostic tool in Alzheimer's disease?

    abstract:PURPOSE:Alzheimer's disease (AD) is a primary degenerative disease that progressively affects all brain functions, with devastating consequences for the patient, the patient's family and society. Rest regional cerebral blood flow (rCBF) could have a strategic role in differentiating between AD patients and normal contr...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-005-1874-0

    authors: Sundström T,Elgh E,Larsson A,Näsman B,Nyberg L,Riklund KA

    更新日期:2006-01-01 00:00:00

  • Multiparametric PET imaging in thyroid malignancy characterizing tumour heterogeneity: somatostatin receptors and glucose metabolism.

    abstract:PURPOSE:Radiolabelled somatostatin (SST) analogues have proven useful in diagnosing tumours positive for SST receptor (SSTR). As different subtypes of SSTR are expressed on the tumour cell surface, the choice of appropriate therapeutic SST analogue is crucial. We evaluated the SSTR status of thyroid cancer patients who...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-015-3114-6

    authors: Traub-Weidinger T,Putzer D,von Guggenberg E,Dobrozemsky G,Nilica B,Kendler D,Bale R,Virgolini IJ

    更新日期:2015-12-01 00:00:00

  • Dynamic PET/CT imaging of 18F-(2S, 4R)4-fluoroglutamine in healthy volunteers and oncological patients.

    abstract:PURPOSE:The purpose of this study was to compare dynamic 18F-FGln PET/CT images of healthy subjects and cancer patients and explore the best imaging phase for different cancers. METHODS:Thirteen healthy volunteers and 31 cancer patients separately underwent 18F-FGln and 18F-FDG PET/CT scans within 1 week. The distribu...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-019-04543-w

    authors: Xu X,Zhu H,Liu F,Zhang Y,Yang J,Zhang L,Xie Q,Zhu L,Li N,Kung HF,Yang Z

    更新日期:2020-09-01 00:00:00

  • Head to head comparison of [18F] AV-1451 and [18F] THK5351 for tau imaging in Alzheimer's disease and frontotemporal dementia.

    abstract:PURPOSE:Tau accumulation is a core pathologic change in various neurodegenerative diseases including Alzheimer's disease and frontotemporal lobar degeneration-tau. Recently, tau positron emission tomography tracers such as [18F] AV-1451 and [18F] THK5351 have been developed to detect tau deposition in vivo. In the pres...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-017-3876-0

    authors: Jang YK,Lyoo CH,Park S,Oh SJ,Cho H,Oh M,Ryu YH,Choi JY,Rabinovici GD,Kim HJ,Moon SH,Jang H,Lee JS,Jagust WJ,Na DL,Kim JS,Seo SW

    更新日期:2018-03-01 00:00:00

  • Segmental quantitative myocardial perfusion with PET for the detection of significant coronary artery disease in patients with stable angina.

    abstract:PURPOSE:The goal of this study is to determine the technical accuracy of segmental perfusion parameters assessed with quantitative cardiac PET imaging in the evaluation of coronary artery disease (CAD) in patients with stable angina. METHODS:A cohort of patients who participated in the EVINCI protocol underwent an eva...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-016-3362-0

    authors: Berti V,Sciagrà R,Neglia D,Pietilä M,Scholte AJ,Nekolla S,Rouzet F,Pupi A,Knuuti J

    更新日期:2016-07-01 00:00:00

  • EANM/ESC guidelines for radionuclide imaging of cardiac function.

    abstract::Radionuclide imaging of cardiac function represents a number of well-validated techniques for accurate determination of right (RV) and left ventricular (LV) ejection fraction (EF) and LV volumes. These first European guidelines give recommendations for how and when to use first-pass and equilibrium radionuclide ventri...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,实务指引

    doi:10.1007/s00259-007-0694-9

    authors: Hesse B,Lindhardt TB,Acampa W,Anagnostopoulos C,Ballinger J,Bax JJ,Edenbrandt L,Flotats A,Germano G,Stopar TG,Franken P,Kelion A,Kjaer A,Le Guludec D,Ljungberg M,Maenhout AF,Marcassa C,Marving J,McKiddie F,Schaefer

    更新日期:2008-04-01 00:00:00

  • An imaging co-registration system using novel non-invasive and non-radioactive external markers.

    abstract::We present a system of image co-registration and its validation in phantom and volunteer studies. The system co-registered images via six novel non-invasive and non-radioactive external markers. The fiducial markers were attached with sponge bases on the skin surface of the phantom and the volunteers in a non-collinea...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-003-1173-6

    authors: Wu TH,Wang JK,Lee JJ,Liu RS,Guo WY

    更新日期:2003-06-01 00:00:00

  • Iodine-123 as a diagnostic imaging agent in differentiated thyroid carcinoma: a comparison with iodine-131 post-treatment scanning and serum thyroglobulin measurement.

    abstract:PURPOSE:Using 123I for diagnostic purposes avoids the risk of stunning for subsequent radioiodine treatment and affords an excellent image quality. In this study we assessed the role of 123I in comparison with 131I post-treatment imaging in patients with thyroid cancer. METHODS:We compared a total of 292 123I scans wi...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-006-0341-x

    authors: Urhan M,Dadparvar S,Mavi A,Houseni M,Chamroonrat W,Alavi A,Mandel SJ

    更新日期:2007-07-01 00:00:00

  • Myocardial perfusion scintigraphy and echocardiography for detecting coronary artery disease in hypertensive patients: a meta-analysis.

    abstract:PURPOSE:This meta-analysis summarized the accuracy of stress myocardial perfusion scintigraphy (MPS) and stress echocardiography for the diagnosis of coronary artery disease (CAD) in patients with arterial hypertension. METHODS:We searched for studies in which stress MPS or stress echocardiography were performed to de...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00259-011-1891-0

    authors: Gargiulo P,Petretta M,Bruzzese D,Cuocolo A,Prastaro M,D'Amore C,Vassallo E,Savarese G,Marciano C,Paolillo S,Filardi PP

    更新日期:2011-11-01 00:00:00

  • Correlation between combining 18F-FDG PET/CT metabolic parameters and other clinical features and ALK or ROS1 fusion in patients with non-small-cell lung cancer.

    abstract:PURPOSE:Our study intended to explore the association between combining 18F-FDG PET/CT metabolic parameters and other clinical features and anaplastic lymphoma kinase (ALK) or c-ros oncogene 1 (ROS1) fusion in non-small-cell lung cancer (NSCLC). METHODS:Eight hundred and six patients with wild-type epidermal growth fa...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-019-04652-6

    authors: Ruan M,Liu L,Wang L,Lei B,Sun X,Chang C,Shen Y,Xie W

    更新日期:2020-05-01 00:00:00

  • Regional [18F]flortaucipir PET is more closely associated with disease severity than CSF p-tau in Alzheimer's disease.

    abstract:PURPOSE:In vivo Alzheimer's disease (AD) biomarkers for tau pathology are cerebrospinal fluid (CSF) phosphorylated tau (p-tau) and [18F]flortaucipir positron emission tomography (PET). Our aim was to assess associations between CSF p-tau with [18F]flortaucipir PET and the associations of both tau biomarkers with cognit...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-020-04758-2

    authors: Wolters EE,Ossenkoppele R,Verfaillie SCJ,Coomans EM,Timmers T,Visser D,Tuncel H,Golla SSV,Windhorst AD,Boellaard R,van der Flier WM,Teunissen CE,Scheltens P,van Berckel BNM

    更新日期:2020-11-01 00:00:00

  • Feasibility of multi-parametric PET and MRI for prediction of tumour recurrence in patients with glioblastoma.

    abstract:BACKGROUND:Recurrence in glioblastoma patients often occur close to the original tumour and indicates that the current treatment is inadequate for local tumour control. In this study, we explored the feasibility of using multi-modality imaging at the time of radiotherapy planning. Specifically, we aimed to identify par...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-018-4180-3

    authors: Lundemann M,Munck Af Rosenschöld P,Muhic A,Larsen VA,Poulsen HS,Engelholm SA,Andersen FL,Kjær A,Larsson HBW,Law I,Hansen AE

    更新日期:2019-03-01 00:00:00

  • The impact of revascularization on myocardial blood flow as assessed by positron emission tomography.

    abstract:PURPOSE:Revascularization aims to improve myocardial perfusion. However, changes in regional artery-specific quantitative perfusion after revascularization have not been systematically investigated. It is unclear whether artery-specific thresholds for coronary flow capacity (CFC) and/or relative perfusion predict impro...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-019-04278-8

    authors: Bober RM,Milani RV,Oktay AA,Javed F,Polin NM,Morin DP

    更新日期:2019-06-01 00:00:00

  • Diagnostic performance of ¹⁸F-fluorothymidine PET/CT for primary colorectal cancer and its lymph node metastasis: comparison with ¹⁸F-fluorodeoxyglucose PET/CT.

    abstract:PURPOSE:To examine the diagnostic performance of (18)F-fluorothymidine (FLT) PET/CT in primary and metastatic lymph node colorectal cancer foci in comparison with (18)F-fluorodeoxyglucose (FDG) PET/CT. METHODS:The study population comprised 28 patients with 30 newly diagnosed colorectal cancers who underwent surgical ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-013-2424-9

    authors: Nakajo M,Nakajo M,Kajiya Y,Jinguji M,Nishimata N,Shimaoka S,Nihara T,Aridome K,Tanaka S,Fukukura Y,Tani A,Koriyama C

    更新日期:2013-08-01 00:00:00

  • Predictive value of early and late residual 18F-fluorodeoxyglucose and 18F-fluorothymidine uptake using different SUV measurements in patients with non-small-cell lung cancer treated with erlotinib.

    abstract:PURPOSE:To evaluate the predictive value of early and late residual (18)F-fluorodeoxyglucose (FDG) and (18)F-fluorothymidine (FLT) uptake using different SUV measurements in PET in patients with advanced non-small-cell lung cancer (NSCLC) treated with erlotinib. METHODS:We retrospectively reviewed data from 30 patient...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-012-2118-8

    authors: Kobe C,Scheffler M,Holstein A,Zander T,Nogova L,Lammertsma AA,Boellaard R,Neumaier B,Ullrich RT,Dietlein M,Wolf J,Kahraman D

    更新日期:2012-07-01 00:00:00

  • Non-small-cell lung cancer resectability: diagnostic value of PET/MR.

    abstract:PURPOSE:To assess the diagnostic performance of PET/MR in patients with non-small-cell lung cancer. METHODS:Fifty consecutive consenting patients who underwent routine (18)F-FDG PET/CT for potentially radically treatable lung cancer following a staging CT scan were recruited for PET/MR imaging on the same day. Two exp...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-014-2873-9

    authors: Fraioli F,Screaton NJ,Janes SM,Win T,Menezes L,Kayani I,Syed R,Zaccagna F,O'Meara C,Barnes A,Bomanji JB,Punwani S,Groves AM

    更新日期:2015-01-01 00:00:00

  • Preliminary results on response assessment using 68Ga-HBED-CC-PSMA PET/CT in patients with metastatic prostate cancer undergoing docetaxel chemotherapy.

    abstract:PURPOSE:To investigate the value of 68Ga-HBED-CC PSMA (68Ga-PSMA) PET/CT for response assessment in metastatic castration-sensitive and castration-resistant prostate cancer (mCSPC and mCRPC) during docetaxel chemotherapy. METHODS:68Ga-PSMA PET/CT was performed in seven mCSPC patients before and after six cycles of upf...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-017-3887-x

    authors: Seitz AK,Rauscher I,Haller B,Krönke M,Luther S,Heck MM,Horn T,Gschwend JE,Schwaiger M,Eiber M,Maurer T

    更新日期:2018-04-01 00:00:00

  • 18F-FDG PET/CT in paediatric lymphoma: comparison with conventional imaging.

    abstract:PURPOSE:In children with Hodgkin's disease and non-Hodgkin's lymphoma, the ability of (18)F-fluoro-2-deoxy-D-glucose PET/CT and conventional imaging (CI) to detect malignant lesions and predict poor lesion response to therapy was assessed and compared. METHODS:A retrospective review of findings reported on PET/CT and ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-010-1619-6

    authors: London K,Cross S,Onikul E,Dalla-Pozza L,Howman-Giles R

    更新日期:2011-02-01 00:00:00