Abstract：
PURPOSE:Alzheimer's disease (AD) is a primary degenerative disease that progressively affects all brain functions, with devastating consequences for the patient, the patient's family and society. Rest regional cerebral blood flow (rCBF) could have a strategic role in differentiating between AD patients and normal controls, but its use for this purpose has a low discriminatory capacity. The purpose of this study was to evaluate whether the diagnostic sensitivity of rCBF single-photon emission computed tomography (SPECT) could be increased by using an episodic memory task provocation, i.e. memory-provoked rCBF-SPECT (MP-SPECT). METHODS:Eighteen persons (73.2+/-4.8 years) with mild AD and 18 healthy elderly (69.4+/-3.9 years) were included in the study. The subjects were injected with (99m)Tc-hexamethylpropylene amine oxime (HMPAO) during memory provocation with faces and names, followed by an rCBF-SPECT study. The rCBF (99m)Tc-HMPAO SPECT images were analysed using statistical parametric mapping (SPM2). Peaks with a false discovery rate corrected value of 0.05 were considered significant. RESULTS:On MP-SPECT, the AD group showed a significant rCBF reduction in the left parietal cortex in comparison with healthy elderly. At rest, no significant group differences were seen. CONCLUSION:Memory provocation increased the sensitivity of rCBF-SPECT for the detection of AD-related blood flow changes in the brain at the group level. Further studies are needed to evaluate MP-SPECT as a diagnostic tool at the individual level. If a higher sensitivity for AD at the individual level is verified in future studies, a single MP-SPECT study might be sufficient in the clinical setting.
journal_name
Eur J Nucl Med Mol Imagingauthors
Sundström T,Elgh E,Larsson A,Näsman B,Nyberg L,Riklund KAdoi
10.1007/s00259-005-1874-0subject
Has Abstractpub_date
2006-01-01 00:00:00pages
73-80issue
1eissn
1619-7070issn
1619-7089journal_volume
33pub_type
杂志文章abstract：PURPOSE:To evaluate, in patients with chest pain, the diagnostic value of ST elevation (STE) in lead aVR during stress testing prior to (99m) Tc-sestamibi scanning correlating ischaemic territory with angiographic findings. METHODS:Consecutive patients attending for (99m) Tc-sestamibi myocardial perfusion imaging (MPI...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2007-03-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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abstract：UNLABELLED:The aim of this study was to evaluate the feasibility of using [(18)F] 3'-deoxy-3'-fluorothymidine (FLT) positron emission tomography (PET) for the diagnosis and grading of brain tumors. METHODS:The patient population comprised 26 patients (15 males, 11 females) with brain tumors (n=18) or nontumorous lesio...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 临床试验,杂志文章
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
doi：10.1007/s00259-020-04772-4
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章,评审
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2006-05-01 00:00:00
abstract：UNLABELLED:There are specific dose recommendations for diagnostic amyloid PET imaging with 18F-florbetapir, but they may not apply to research studies using regional quantitative analysis. We, therefore, studied the effect of tracer dose reduction on the discriminative power of regional analysis. METHODS:Using bootstr...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
doi：10.1007/s00259-014-2842-3
更新日期：2014-11-01 00:00:00
abstract：PURPOSE:The future significance of peptide radiopharmaceuticals in diagnostic imaging with PET will be dependent on methodological aspects, as well as other requirements such as availability of the radionuclide and cost-effectiveness of its production. The aim of this study was to evaluate whether recent improvements i...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
doi：10.1007/s00259-004-1582-1
更新日期：2004-12-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
doi：10.1007/s00259-014-2902-8
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Recurrence in glioblastoma patients often occur close to the original tumour and indicates that the current treatment is inadequate for local tumour control. In this study, we explored the feasibility of using multi-modality imaging at the time of radiotherapy planning. Specifically, we aimed to identify par...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 临床试验,杂志文章
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更新日期：2019-03-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2012-02-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章,多中心研究
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更新日期：2009-03-01 00:00:00
abstract：:Mild cognitive impairment is characterized by a decline in cognitive performance without interference with activities of daily living. The amnestic subtype of mild cognitive impairment progresses to Alzheimer's disease at a rate of 10-15% per year and in the majority the neuropathology is intermediate between the neur...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章,评审
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
doi：10.1007/s00259-016-3575-2
更新日期：2017-02-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
doi：10.1007/s00259-006-0343-8
更新日期：2007-07-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2003-09-01 00:00:00
abstract：PURPOSE:4'-[Methyl-11C] thiothymidine (4DST) incorporates into DNA directly and is a PET tracer used for cell proliferation imaging. The aim of this study was to evaluate the prediction of prognosis with pretreatment 4DST PET/CT compared to fluorodeoxyglucose (FDG) PET/CT in patients with esophageal cancer. METHODS:In...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
doi：10.1007/s00259-020-05179-x
更新日期：2021-01-12 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2018-12-01 00:00:00
abstract：PURPOSE:Tau accumulation is a core pathologic change in various neurodegenerative diseases including Alzheimer's disease and frontotemporal lobar degeneration-tau. Recently, tau positron emission tomography tracers such as [18F] AV-1451 and [18F] THK5351 have been developed to detect tau deposition in vivo. In the pres...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
doi：10.1007/s00259-017-3876-0
更新日期：2018-03-01 00:00:00
abstract：PURPOSE:Here, the expression of F4/80 on the cell surface of murine macrophages was exploited to develop a novel imaging tracer that could visualize macrophages in vivo. METHODS:The immunoreactive fraction and IC50 of anti-F4/80-A3-1, conjugated with diethylenetriaminepentaacetic acid (DTPA) and radiolabelled with (11...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2015-08-01 00:00:00
abstract：PURPOSE:Pretargeted radioimmunotherapy (PRIT) with bispecific antibodies (bsMAb) and a radiolabeled peptide reduces the radiation dose to normal tissues. Here we report the accuracy of an (111)In-labeled pretherapy test dose for personalized dosing of (177)Lu-labeled IMP288 following pretargeting with the anti-CEA × an...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 临床试验,杂志文章
doi：10.1007/s00259-014-2742-6
更新日期：2014-08-01 00:00:00
