Gallium-labelled peptides for imaging of inflammation.

abstract：PURPOSE:The objective of this study was to explore the feasibility of harmonising performance for PET/CT systems equipped with time-of-flight (ToF) and resolution modelling/point spread function (PSF) technologies. A second aim was producing a working prototype of new harmonising criteria with higher contrast recoverie...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kaalep A,Sera T,Rijnsdorp S,Yaqub M,Talsma A,Lodge MA,Boellaard R

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:Levodopa and dopamine (DA) agonist therapy are two common treatments for Parkinson's disease (PD). There is controversy about the effects of these treatments on disease progression and imaging markers. Here we used multi-tracer positron emission tomography imaging and a unilateral 6-hydroxydopamine (6-OHDA) rat...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sossi V,Dinelle K,Schulzer M,Mak E,Doudet DJ,de la Fuente-Fernández R

更新日期：2010-12-01 00:00:00

abstract：:Orthostatic hypotension (OH) can be present in idiopathic Parkinson's disease (IPD) as well as in atypical parkinsonian syndromes such as multiple system atrophy (MSA). According to clinical tests of sympathetic nerve function and histopathological data, OH is caused by primarily postganglionic sympathetic dysfunction...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Berding G,Schrader CH,Peschel T,van den Hoff J,Kolbe H,Meyer GJ,Dengler R,Knapp WH

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Although [(18)F]FDG PET can measure therapy response sooner and more accurately than morphological imaging techniques, there is still some debate as to whether [(18)F]FDG uptake really reflects changes in the viable cell fraction. In this study changes in [(18)F]FDG uptake were investigated in a lymphoma model ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Brepoels L,De Saint-Hubert M,Stroobants S,Verhoef G,Balzarini J,Mortelmans L,Mottaghy FM

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Rhenium-188-HEDP is a beta-emitting radiopharmaceutical used for palliation of metastatic bone pain. We investigated whether the addition of rhenium-188-HEDP to docetaxel/prednisone improved efficacy of chemotherapy in patients with CRPC. METHODS:Patients with progressive CRPC and osteoblastic bone metastas...

journal_title：European journal of nuclear medicine and molecular imaging

authors： van Dodewaard-de Jong JM,de Klerk JMH,Bloemendal HJ,Oprea-Lager DE,Hoekstra OS,van den Berg HP,Los M,Beeker A,Jonker MA,O'Sullivan JM,Verheul HMW,van den Eertwegh AJM

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:Castration-resistant prostate cancer (CRPC) is the most common cause of death in men. The effectiveness of HDAC inhibitors has been demonstrated by preclinical models, but not in clinical studies, probably due to the ineffectively accumulation of HDACI in prostate cancer cells. The purpose of this work was to e...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Chen Z,Wang X,Yang X,Xu Y,Yang Y,Wang H,Li T,Bai P,Yuan G,Chen H,Yang J,Fiedler SA,Striar R,Bernales DR,Koegel RE,Cao Q,Ran C,Xiang B,Li H,Wang C

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:To study the effect of adjuvant lithium on serum thyroxine (T4) concentrations in patients treated with radioactive iodine (RAI) therapy in our environment. METHODS:This was a prospective simple randomized comparative, experimental cohort study of patients with hyperthyroidism referred for RAI ablation therapy...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Hammond EN,Vangu MD

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Bone pain is a common symptom of metastatic disease in cancer, experienced with various intensities by about 30% of cancer patients, during the development of their disease, up to 60-90% in the latest phases. DISCUSSION:In addition to other therapies, such as analgesics, bisphosphonates, chemotherapy, hor...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Bodei L,Lam M,Chiesa C,Flux G,Brans B,Chiti A,Giammarile F,European Association of Nuclear Medicine (EANM).

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Acute complicated pyelonephritis (ACP) is an upper urinary tract infection associated with coexisting urinary tract abnormalities or medical conditions that could predispose to serious outcomes or treatment failures. Although CT and magnetic resonance imaging (MRI) are frequently used in patients with ACP, t...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Wan CH,Tseng JR,Lee MH,Yang LY,Yen TC

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:(18)F-8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ((18)F-CPFPX) is a potent radioligand to study human cerebral A(1) adenosine receptors and their neuromodulatory and neuroprotective functions with positron emission tomography (PET). The purpose of this study was to determine the biodistribution and the r...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Herzog H,Elmenhorst D,Winz O,Bauer A

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To evaluate, in patients with chest pain, the diagnostic value of ST elevation (STE) in lead aVR during stress testing prior to (99m) Tc-sestamibi scanning correlating ischaemic territory with angiographic findings. METHODS:Consecutive patients attending for (99m) Tc-sestamibi myocardial perfusion imaging (MPI...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Neill J,Shannon HJ,Morton A,Muir AR,Harbinson M,Adgey JA

更新日期：2007-03-01 00:00:00

abstract：INTRODUCTION:Positron emission tomography (PET) is a fully quantitative technology for imaging metabolic pathways and dynamic processes in vivo. Attenuation correction of raw PET data is a prerequisite for quantification and is typically based on separate transmission measurements. In PET/CT attenuation correction, how...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Hofmann M,Pichler B,Schölkopf B,Beyer T

更新日期：2009-03-01 00:00:00

abstract：:Characterisation of the physical performance of the new integrated PET/CT system Discovery ST (GE Medical Systems) has been performed following the NEMA NU 2-1994 (N-94) and the NEMA NU 2-2001 (N-01) standards in both 2D and 3D acquisition configuration. The Discovery ST combines a four or eight multi-slice helical CT...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Bettinardi V,Danna M,Savi A,Lecchi M,Castiglioni I,Gilardi MC,Bammer H,Lucignani G,Fazio F

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to compare image quality and lesion detection capability between a digital and an analog PET/CT system in oncological patients. MATERIALS AND METHODS:One hundred oncological patients (62 men, 38 women; mean age of 65 ± 12 years) were prospectively included from January-June 2018...

journal_title：European journal of nuclear medicine and molecular imaging

authors： López-Mora DA,Flotats A,Fuentes-Ocampo F,Camacho V,Fernández A,Ruiz A,Duch J,Sizova M,Domènech A,Estorch M,Carrió I

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:Sympathetic nervous system (SNS) hyperactivity is a salient characteristic of chronic heart failure (HF) and contributes to the progression of the disease. Iodine-123 meta-iodobenzylguanidine (123I-mIBG) imaging has been successfully used to assess cardiac SNS activity in HF patients and to predict prognosis. I...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Rengo G,Pagano G,Vitale DF,Formisano R,Komici K,Petraglia L,Parisi V,Femminella GD,de Lucia C,Paolillo S,Cannavo A,Attena E,Pellegrino T,Dellegrottaglie S,Memmi A,Trimarco B,Cuocolo A,Filardi PP,Leosco D,Ferrara N

更新日期：2016-12-01 00:00:00

abstract：:Dynamic PET (dPET) studies have been used until now primarily within research purposes. Although it is generally accepted that the information provided by dPET is superior to that of conventional static PET acquisitions acquired usually 60 min post injection of the radiotracer, the duration of dynamic protocols, the l...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Dimitrakopoulou-Strauss A,Pan L,Sachpekidis C

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:To evaluate the relationship between coronary artery calcium (CAC) and coronary vasodilator function. METHODS:We evaluated 136 patients without known coronary artery disease (CAD) undergoing vasodilator stress (82)Rb PET/CT and CAC scoring who showed normal myocardial perfusion. The CAC score, resting and hype...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Curillova Z,Yaman BF,Dorbala S,Kwong RY,Sitek A,El Fakhri G,Anagnostopoulos C,Di Carli MF

更新日期：2009-10-01 00:00:00

abstract：:The aim of this study was to evaluate fluorine-18 fluorodeoxyglucose ([(18)F]FDG) imaging of head and neck tumours using a second- or third-generation hybrid PET device. Results were compared with the findings of spiral computed tomography (CT) and magnetic resonance imaging (MRI), and, as regards lymph node metastasi...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Dresel S,Grammerstorff J,Schwenzer K,Brinkbäumer K,Schmid R,Pfluger T,Hahn K

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:Monoclonal anti-CD33 antibodies conjugated with toxic calicheamicin derivative (gemtuzumab ozogamicin, GO) are a novel therapy option for acute myeloid leukaemia (AML). Key prognostic factors for patients with AML are high CD33 expression on the leukaemic cells and the ability to overcome mechanisms of resistan...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Petrich T,Korkmaz Z,Krull D,Frömke C,Meyer GJ,Knapp WH

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:For the assessment of folate-based radiopharmaceuticals, human nasopharyngeal KB carcinoma cells are traditionally used although nasopharyngeal cancer is rare. On the other hand, the folate receptor (FR) is frequently overexpressed on diverse cancer types, the highest frequency (>90%) being on ovarian carcinoma...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Müller C,Schubiger PA,Schibli R

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:We investigated the performance of the Inveon small-animal PET/SPECT/CT system and compared the imaging capabilities of the SPECT and PET components. METHODS:For SPECT, the energy resolution, tomographic spatial resolution and system sensitivity were evaluated with a (99m)Tc solution using a single pinhole col...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Magota K,Kubo N,Kuge Y,Nishijima K,Zhao S,Tamaki N

更新日期：2011-04-01 00:00:00

abstract：INTRODUCTION:Fluorescence guidance is an upcoming methodology to improve surgical accuracy. Challenging herein is the identification of the minimum dose at which the tracer can be detected with a clinical-grade fluorescence camera. Using a hybrid tracer such as indocyanine green (ICG)-(99m)Tc-nanocolloid, it has become...

journal_title：European journal of nuclear medicine and molecular imaging

authors： KleinJan GH,Bunschoten A,van den Berg NS,Olmos RA,Klop WM,Horenblas S,van der Poel HG,Wester HJ,van Leeuwen FW

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:Functional activation protocols are widely applied for the study of brain-cognition relations. Only few take advantage of the intrinsic characteristics of SPECT, particularly those allowing cognitive assessment outside of the camera, in settings close to the standard clinical or laboratory ones. The purpose of ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ludwig C,Chicherio C,Terraneo L,Magistretti P,de Ribaupierre A,Slosman D

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate therapeutic response to neoadjuvant chemotherapy (NAC) and predict breast cancer recurrence using Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST). MATERIALS AND METHODS:Fifty-nine breast cancer patients underwent fluorodeoxyglucose-positron emi...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kitajima K,Nakatani K,Yamaguchi K,Nakajo M,Tani A,Ishibashi M,Hosoya K,Morita T,Kinoshita T,Kaida H,Miyoshi Y

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:To evaluate the diagnostic potential of PET/MRI with [(18)F]FDG in recurrent ovarian and cervical cancer in comparison to PET/CT. METHODS:A group of 19 patients with suspected recurrence of pelvic malignancies (ovarian cancer, 11 patients; cervical cancer, 8 patients) scheduled for an [(18)F]FDG PET/CT were su...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Beiderwellen K,Grueneisen J,Ruhlmann V,Buderath P,Aktas B,Heusch P,Kraff O,Forsting M,Lauenstein TC,Umutlu L

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Aortic metabolic activity is suggested to correlate with presence and progression of aneurysmal disease, but has been inadequately studied. This study investigates the 2-[(18)F] fluoro-2-deoxy-D-glucose ((18)F-FDG) uptake in a population of infra-renal abdominal aortic aneurysms (AAA), compared to a matched non...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Barwick TD,Lyons OT,Mikhaeel NG,Waltham M,O'Doherty MJ

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Pretargeted radioimmunotherapy (PRIT) with bispecific antibodies (bsMAb) and a radiolabeled peptide reduces the radiation dose to normal tissues. Here we report the accuracy of an (111)In-labeled pretherapy test dose for personalized dosing of (177)Lu-labeled IMP288 following pretargeting with the anti-CEA × an...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Schoffelen R,Woliner-van der Weg W,Visser EP,Goldenberg DM,Sharkey RM,McBride WJ,Chang CH,Rossi EA,van der Graaf WT,Oyen WJ,Boerman OC

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:Improved bifunctional chelates (BFCs) are needed to facilitate efficient (64)Cu radiolabeling of monoclonal antibodies (mAbs) under mild conditions and to yield stable, target-specific agents. The utility of two novel BFCs, 1-Oxa-4,7,10-triazacyclododecane-5-S-(4-isothiocyanatobenzyl)-4,7,10-triacetic acid (p-S...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ferreira CL,Yapp DT,Crisp S,Sutherland BW,Ng SS,Gleave M,Bensimon C,Jurek P,Kiefer GE

更新日期：2010-11-01 00:00:00

abstract：:Radioiodine therapy is now the most common definite treatment for persistent hyperthyroidism. The outcome of radioiodine therapy depends mainly on the absorbed energy dose in the diseased thyroid tissue. The administered activity and the resulting target dose in the thyroid depend on both the biokinetics of radioiodin...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Moka D,Dietlein M,Schicha H

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:The histamine H3 receptors are presynaptic neuroreceptors that inhibit the release of histamine and other neurotransmitters. The receptors are considered a drug target for sleep disorders and neuropsychiatric disorders with cognitive decline. We developed a novel PET ligand for the H3 receptors, [(11)C]TASP0410...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kimura Y,Seki C,Ikoma Y,Ichise M,Kawamura K,Takahata K,Moriguchi S,Nagashima T,Ishii T,Kitamura S,Niwa F,Endo H,Yamada M,Higuchi M,Zhang MR,Suhara T

更新日期：2016-08-01 00:00:00