Abstract：
PURPOSE:We investigated the performance of the Inveon small-animal PET/SPECT/CT system and compared the imaging capabilities of the SPECT and PET components. METHODS:For SPECT, the energy resolution, tomographic spatial resolution and system sensitivity were evaluated with a (99m)Tc solution using a single pinhole collimator. For PET, the spatial resolution, absolute sensitivity, scatter fraction and peak noise equivalent count were evaluated. Phantoms and a normal rat were scanned to compare the imaging capabilities of SPECT and PET. RESULTS:The SPECT spatial resolution was 0.84 mm full-width at half-maximum (FWHM) at a radius of rotation of 25 mm using a 0.5-mm pinhole aperture collimator, while the PET spatial resolution was 1.63 mm FWHM at the centre. The SPECT system sensitivity at a radius of rotation of 25 mm was 35.3 cps/MBq (4 × 10(-3)%) using the 0.5-mm pinhole aperture, while the PET absolute sensitivity was 3.2% for 350-650 keV and 3.432 ns. Accordingly, the volume sensitivity of PET was three orders of magnitude higher than that of SPECT. CONCLUSION:This integrated PET/SPECT/CT system showed high performance with excellent spatial resolution for SPECT and sensitivity for PET. Based on the tracer availability and system performance, SPECT and PET have complementary roles in multimodality small-animal imaging.
journal_name
Eur J Nucl Med Mol Imagingauthors
Magota K,Kubo N,Kuge Y,Nishijima K,Zhao S,Tamaki Ndoi
10.1007/s00259-010-1683-ysubject
Has Abstractpub_date
2011-04-01 00:00:00pages
742-52issue
4eissn
1619-7070issn
1619-7089journal_volume
38pub_type
杂志文章abstract：PURPOSE:It was previously demonstrated that radiation effects can enhance the therapy outcome of immune checkpoint inhibitors. In this study, a syngeneic breast tumor mouse model was used to investigate the effect of [177Lu]Lu-DOTA-folate as an immune stimulus to enhance anti-CTLA-4 immunotherapy. METHODS:In vitro and...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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abstract：PURPOSE:Positron emission tomography (PET) imaging of serotonin 2A (5-HT(2A)) receptors with agonist tracers holds promise for the selective labelling of 5-HT(2A) receptors in their high-affinity state. We have previously validated [(11)C]Cimbi-5 and found that it is a 5-HT(2A) receptor agonist PET tracer. In an attemp...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
doi：10.1007/s00259-010-1686-8
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
doi：10.1007/s00259-006-0343-8
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 临床试验,杂志文章
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更新日期：2011-09-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 临床试验,杂志文章
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更新日期：2003-01-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
doi：10.1007/s00259-011-1976-9
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abstract：:Jérôme Barriere was inadvertently missing in the original version of this article. He has participated to the study design, protocol writing and inclusion of a significant number of patients. ...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 已发布勘误
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abstract：PURPOSE:Trastuzumab (Herceptin™) is often internalized following binding to Her2+ tumor cells. The objective of this study was to investigate whether trastuzumab can be used as a specific carrier to deliver antisense oligomers into Her2+ tumor cells both in vitro and in vivo. METHODS:A biotinylated MORF oligomer antis...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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abstract：:Functional imaging of small animals, such as mice and rats, using ultra-high resolution positron emission tomography (PET) and single-photon emission tomography (SPET), is becoming a valuable tool for studying animal models of human disease. While several studies have shown the utility of PET imaging in small animals,...
journal_title：European journal of nuclear medicine and molecular imaging
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更新日期：2002-05-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
doi：10.1007/s00259-017-3831-0
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pub_type： 杂志文章,评审
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2009-07-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章,多中心研究
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 临床试验,杂志文章
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abstract：:The evaluation of myocardial glucose utilisation with fluorine-18 fluorodeoxyglucose (FDG) and positron emission tomography is currently considered the most reliable tool for the identification of myocardial viability. However, the investigations using FDG imaging to predict improvement in left ventricular (LV) functi...
journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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abstract：PURPOSE:To contribute to the differentiation of Parkinson's disease (PD) and essential tremor (ET), we compared two different artificial neural network classifiers using (123)I-FP-CIT SPECT data, a probabilistic neural network (PNN) and a classification tree (ClT). METHODS:(123)I-FP-CIT brain SPECT with semiquantitati...
journal_title：European journal of nuclear medicine and molecular imaging
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abstract：PURPOSE:Radiolabelled meta-iodobenzylguanidine (mIBG), used as targeted therapy for neuroblastoma, is known to have effects on blood pressure (BP). In this study we audited BP changes in patients receiving (131)I-mIBG therapy for neuroblastoma to identify BP-related adverse events (AE) and possible predictive factors. ...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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abstract：PURPOSE:(11)C-PK11195 is a radiopharmaceutical for in vivo assessment of peripheral benzodiazepine receptor (PBR) activity using PET. We sought to clarify the metabolic fate of (11)C-PK11195 in a test-retest setting using radio-HPLC in comparison with radio-TLC, and the whole-body distribution in humans. MATERIALS AND...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
doi：10.1007/s00259-008-1000-1
更新日期：2009-04-01 00:00:00
