Whole-body distribution and metabolism of [N-methyl-11C](R)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide in humans; an imaging agent for in vivo assessment of peripheral benzodiazepine receptor activity with positron emission tomography

abstract：PURPOSE:The purpose of this study was to evaluate the impact of [18F]fluorodeoxy-D-glucose positron emission tomography (FDG-PET) on the primary staging of patients with small-cell lung cancer (SCLC). METHODS:FDG-PET was performed in 120 consecutive patients with SCLC during primary staging. In addition, brain examina...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Brink I,Schumacher T,Mix M,Ruhland S,Stoelben E,Digel W,Henke M,Ghanem N,Moser E,Nitzsche EU

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to assess radiomics features on pre-treatment [18F]FDG positron emission tomography (PET) as potential biomarkers for response and survival in patients with metastatic colorectal cancer (mCRC). METHODS:Patients with mCRC underwent [18F]FDG PET/computed tomography (CT) prior to firs...

journal_title：European journal of nuclear medicine and molecular imaging

authors： van Helden EJ,Vacher YJL,van Wieringen WN,van Velden FHP,Verheul HMW,Hoekstra OS,Boellaard R,Menke-van der Houven van Oordt CW

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Genes encoding for intracellular enzymes or transmembrane proteins are suitable as reporters, but may differ in terms of applicability for cardiac imaging. The aim of this study was to compare the human sodium iodide symporter gene (hNIS) with the herpes simplex virus type 1 thymidine kinase gene (HSV1-tk) as t...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Miyagawa M,Anton M,Wagner B,Haubner R,Souvatzoglou M,Gansbacher B,Schwaiger M,Bengel FM

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:Positron emission tomography (PET) radioligands specific to α7 nicotinic acetylcholine receptors (nAChRs) afford in vivo imaging of this receptor for neuropathologies such as Alzheimer's disease, schizophrenia, and substance abuse. This work aims to characterize the kinetic properties of an α7-nAChR-specific ra...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Hillmer AT,Zheng MQ,Li S,Scheunemann M,Lin SF,Holden D,Labaree D,Ropchan J,Teodoro R,Deuther-Conrad W,Carson RE,Brust P,Huang Y

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:Evaluation of the long-term prognostic value of myocardial perfusion imaging (MPI) in octogenarians. METHODS:Six hundred and twenty-nine octogenarians [51% previous myocardial infarction (MI) or revascularization] who underwent single-isotope MPI (78% 201Tl, 22% 99mTc-tetrofosmin) with exercise (38% Bruce, 2% ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Katsikis A,Theodorakos A,Manira V,Papaioannou S,Kolovou G,Voudris V,Koutelou M

更新日期：2017-08-01 00:00:00

abstract：:We evaluated an autoradiographic (ARG) method to calculate regional cerebral blood flow (rCBF) sequentially before and after an acetazolamide (ACZ) challenge in a single session of single-photon emission tomography (SPET) with two injections of N-isopropyl-[(123)I] p-iodoamphetamine (IMP). The method uses a table look...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nishizawa S,Iida H,Tsuchida T,Ito H,Konishi J,Yonekura Y

更新日期：2003-07-01 00:00:00

abstract：:The aim of this study was to describe the anatomical structures that show uptake of the somatostatin analogue octreotide in patients with thyroid-associated orbitopathy (TAO). The study population comprised a series of 20 TAO patients attending the out-patient thyroid clinic and 12 patients presenting head or neck tum...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kainz H,Bale R,Donnemiller E,Gabriel M,Kovacs P,Decristoforo C,Moncayo R

更新日期：2003-08-01 00:00:00

abstract：UNLABELLED:There are specific dose recommendations for diagnostic amyloid PET imaging with 18F-florbetapir, but they may not apply to research studies using regional quantitative analysis. We, therefore, studied the effect of tracer dose reduction on the discriminative power of regional analysis. METHODS:Using bootstr...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Herholz K,Evans R,Anton-Rodriguez J,Hinz R,Matthews JC

更新日期：2014-11-01 00:00:00

abstract：INTRODUCTION:Vascular prosthesis infection (VPI) is a life-threatening complication that occurs in 0.5-5% of prostheses. Low-grade infections in non-acute patients are a diagnostic challenge requiring a new method with good diagnostic accuracy. The aim of this work was to define the accuracy of (18)F-FDG PET/CT in thes...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Spacek M,Belohlavek O,Votrubova J,Sebesta P,Stadler P

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:The 18-kDa mitochondrial translocator protein (TSPO) was reported to be upregulated in gliomas. 18F-GE-180 is a novel 3rd generation TSPO receptor ligand with improved target-to-background contrast compared to previous tracers. In this pilot study, we compared PET imaging with 18F-GE-180 and MRI of patients w...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Albert NL,Unterrainer M,Fleischmann DF,Lindner S,Vettermann F,Brunegraf A,Vomacka L,Brendel M,Wenter V,Wetzel C,Rupprecht R,Tonn JC,Belka C,Bartenstein P,Niyazi M

更新日期：2017-12-01 00:00:00

abstract：:This review summarises the evidence for the role of myocardial perfusion scintigraphy (MPS) in patients with known or suspected coronary artery disease. It is the product of a consensus conference organised by the British Cardiac Society, the British Nuclear Cardiology Society and the British Nuclear Medicine Society ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Underwood SR,Anagnostopoulos C,Cerqueira M,Ell PJ,Flint EJ,Harbinson M,Kelion AD,Al-Mohammad A,Prvulovich EM,Shaw LJ,Tweddel AC,British Cardiac Society.,British Nuclear Cardiology Society.,British Nuclear Medicine Society.,Ro

更新日期：2004-02-01 00:00:00

abstract：PURPOSE:Although resynchronisation therapy (CRT) is a promising addition to heart failure therapy, a substantial number of patients do not respond to CRT. As FDG PET has routinely been used for prediction of improvement after revascularisation in ischaemic cardiomyopathy, it was hypothesised that there is also a relati...

journal_title：European journal of nuclear medicine and molecular imaging

authors： van Campen CM,Visser FC,van der Weerdt AP,Knaapen P,Comans EF,Lammertsma AA,de Cock CC,Visser CA

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:This study was performed to demonstrate that the results obtained with a calibration phantom could be used as a tool for standardizing measurement of heart to mediastinum (H/M) ratio in cardiac metaiodobenzylguanidine (MIBG) imaging. METHODS:Images of the phantom containing (123)I-MIBG were acquired on the cam...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nakajima K,Okuda K,Matsuo S,Yoshita M,Taki J,Yamada M,Kinuya S

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:The nucleoside analog 3'-deoxy-3'-(18)F-fluorothymidine (FLT) has been introduced for imaging cell proliferation with positron emission tomography (PET). We prospectively compared the diagnostic efficacy of FLT PET with that of 2-deoxy-2-(18)F-fluoro-D-glucose (FDG) PET for the preoperative nodal and distant me...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Yamamoto Y,Nishiyama Y,Kimura N,Ishikawa S,Okuda M,Bandoh S,Kanaji N,Asakura M,Ohkawa M

更新日期：2008-02-01 00:00:00

abstract：PURPOSE:The dopamine transporter (DAT) is a plasma membrane protein of central interest in the pathophysiology of neuropsychiatric disorders and is known to be a target for psychostimulant drugs. [(11)C]PE2I is a new radioligand which binds selectively and with moderate affinity to central DAT, as has been demonstrated...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Jucaite A,Odano I,Olsson H,Pauli S,Halldin C,Farde L

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:Patients with persistent elevated PSA and repeated negative prostate biopsy, that means having the prostate biopsied at multiple times, were investigated with 18F-choline PET/CT to delineate prostate cancer and guide renewed prostate biopsy. METHODS:Twenty patients with elevated PSA and negative prostate biops...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Igerc I,Kohlfürst S,Gallowitsch HJ,Matschnig S,Kresnik E,Gomez-Segovia I,Lind P

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Bone metastases are responsible for most of the morbidity associated with hormone-refractory prostate cancer (HRPC). 153Sm-ethylenediaminetetramethylene phosphonate (153Sm-EDTMP) has been approved for palliation of painful skeletal metastases. We retrospectively investigated the possible synergistic effect o...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ricci S,Boni G,Pastina I,Genovesi D,Cianci C,Chiacchio S,Orlandini C,Grosso M,Alsharif A,Chioni A,Di Donato S,Francesca F,Selli C,Rubello D,Mariani G

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:It was previously demonstrated that radiation effects can enhance the therapy outcome of immune checkpoint inhibitors. In this study, a syngeneic breast tumor mouse model was used to investigate the effect of [177Lu]Lu-DOTA-folate as an immune stimulus to enhance anti-CTLA-4 immunotherapy. METHODS:In vitro and...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Guzik P,Siwowska K,Fang HY,Cohrs S,Bernhardt P,Schibli R,Müller C

更新日期：2020-10-19 00:00:00

abstract：PURPOSE:Radioligand therapy (RLT) using Lutetium-177 labeled PSMA-617 (Lu-PSMA) ligand is a new therapeutic option for salvage therapy in heavily pretreated patients with metastatic castration resistant prostate cancer. The aim of this retrospective study was to analyze response in patients receiving 3 cycles of Lu-PSM...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Rahbar K,Bögeman M,Yordanova A,Eveslage M,Schäfers M,Essler M,Ahmadzadehfar H

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:To evaluate the sensitivity and specificity of PET/CT findings in PMR and generate a diagnostic algorithm utilizing a minimum number of musculoskeletal sites. METHODS:Steroid-naïve patients with newly diagnosed PMR (2012 EULAR/ACR classification criteria) were prospectively recruited to undergo whole-body 18F-...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Owen CE,Poon AMT,Yang V,McMaster C,Lee ST,Liew DFL,Leung JL,Scott AM,Buchanan RRC

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:Aortic metabolic activity is suggested to correlate with presence and progression of aneurysmal disease, but has been inadequately studied. This study investigates the 2-[(18)F] fluoro-2-deoxy-D-glucose ((18)F-FDG) uptake in a population of infra-renal abdominal aortic aneurysms (AAA), compared to a matched non...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Barwick TD,Lyons OT,Mikhaeel NG,Waltham M,O'Doherty MJ

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:The aim of the present study is to prospectively evaluate the prognostic value of previously defined [(18)F]2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) criteria of early metabolic response in patients with locally advanced rectal cancer (LARC) after long-term follow-up. METHODS:Forty-two ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Avallone A,Aloj L,Caracò C,Delrio P,Pecori B,Tatangelo F,Scott N,Casaretti R,Di Gennaro F,Montano M,Silvestro L,Budillon A,Lastoria S

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:The aim of this study was to compare the accuracy of (123)I-MIBG SPECT/CT with that of (68)Ga-DOTATOC PET/CT for staging extraadrenal paragangliomas (PGL) using both functional and anatomical images (i.e. combined cross-sectional imaging) as the reference standards. METHODS:The study included three men and sev...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kroiss A,Shulkin BL,Uprimny C,Frech A,Gasser RW,Url C,Gautsch K,Madleitner R,Nilica B,Sprinzl GM,Gastl G,Fraedrich G,Virgolini IJ

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To assess the relationship between serum thyroglobulin (Tg) levels, Tg doubling time (Tg-DT) and the diagnostic performance of (18)F-FDG PET/CT in detecting recurrences of (131)I-negative differentiated thyroid carcinoma (DTC). METHODS:Included in the present study were 102 patients with DTC. All patients were...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Giovanella L,Trimboli P,Verburg FA,Treglia G,Piccardo A,Foppiani L,Ceriani L

更新日期：2013-06-01 00:00:00

abstract：:This study assessed the clinical usefulness of a new technetium-99m labelled somatostatin analogue from the standpoint of oncological diagnostics. The study group comprised 40 patients in whom malignant neoplasms (32 primary and 8 metastatic) had been diagnosed. Among the primary tumours there were 21 cases of lung ca...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Płachcińska A,Mikołajczak R,Maecke HR,Młodkowska E,Kunert-Radek J,Michalski A,Rzeszutek K,Kozak J,Kuśmierek J

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:Reduced presynaptic dopaminergic activity plays an important role in the development of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD). In this study, we investigated whether dopaminergic function in the nigrostriatal system is associated with the timing of LID onset. METHODS:From among 412 drug...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Yoo HS,Chung SJ,Chung SJ,Moon H,Oh JS,Kim JS,Hong JY,Ye BS,Sohn YH,Lee PH

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:To determine the value of (68)Ga-DOTA-TOC and (18)F-FDG PET/CT for initial and follow-up evaluation of patients with neuroendocrine tumour (NET) treated with peptide receptor radionuclide therapy (PRRT). METHODS:We evaluated 66 patients who had histologically proven NET and underwent both PRRT and three combin...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nilica B,Waitz D,Stevanovic V,Uprimny C,Kendler D,Buxbaum S,Warwitz B,Gerardo L,Henninger B,Virgolini I,Rodrigues M

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:Although [(18)F]FDG PET can measure therapy response sooner and more accurately than morphological imaging techniques, there is still some debate as to whether [(18)F]FDG uptake really reflects changes in the viable cell fraction. In this study changes in [(18)F]FDG uptake were investigated in a lymphoma model ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Brepoels L,De Saint-Hubert M,Stroobants S,Verhoef G,Balzarini J,Mortelmans L,Mottaghy FM

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to compare image quality and lesion detection capability between a digital and an analog PET/CT system in oncological patients. MATERIALS AND METHODS:One hundred oncological patients (62 men, 38 women; mean age of 65 ± 12 years) were prospectively included from January-June 2018...

journal_title：European journal of nuclear medicine and molecular imaging

authors： López-Mora DA,Flotats A,Fuentes-Ocampo F,Camacho V,Fernández A,Ruiz A,Duch J,Sizova M,Domènech A,Estorch M,Carrió I

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:Targeted therapy with α-particle emitting radionuclides is a promising new option in cancer therapy. Stable conjugates of the vascular tumour-homing peptide F3 with the α-emitter (213)Bi specifically target tumour cells. The aim of our study was to determine efficacy of combined (213)Bi-diethylenetriaminepentaa...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Vallon M,Seidl C,Blechert B,Li Z,Gilbertz KP,Baumgart A,Aichler M,Feuchtinger A,Gaertner FC,Bruchertseifer F,Morgenstern A,Walch AK,Senekowitsch-Schmidtke R,Essler M

更新日期：2012-12-01 00:00:00